Una preoccupazione per il crescente uso di farmaci da prescrizione durante la gravidanza è il rischio teratogeno. Questo rischio non è determinato per la maggior parte dei farmaci approvati negli Stati Uniti (USA) dal 2000 al 2010. L’acne e la psoriasi sono malattie croniche che si verificano tipicamente durante l’età fertile e poiché i retinoidi topici sono raccomandati sia per il trattamento dell’acne che per la psoriasi, è è possibile che le donne siano esposte a un retinoide topico durante la gravidanza. Gli studi di farmacocinetica mostrano un’esposizione sistemica relativamente bassa ai retinoidi topici, ma i livelli di esposizione che potrebbero portare a teratogenicità nell’uomo non sono noti. Il tazarotene, un retinoide topico, è stato approvato dalla Food and Drug Administration (FDA) statunitense sia per l’acne che per la psoriasi utilizzando i dati di farmacocinetica degli studi sulla psoriasi, che hanno stimato i dati basati sull’uso del tazarotene fino al 20% della superficie corporea.
Pertanto, sia in base all’etichettatura della gravidanza precedente che in quella attuale della FDA, il tazarotene non è raccomandato per l’uso durante la gravidanza. L’obiettivo di questa revisione della letteratura era fornire un contesto storico per la regola di etichettatura della gravidanza per il tazarotene rispetto ad altri retinoidi approvati e raccogliere i dati disponibili sugli esiti della gravidanza correlati a tazarotene e retinoidi. Sebbene vi siano segnalazioni di casi di esposizione topica alla tretinoina e all’adapalene in utero, non è chiaro se entrambe abbiano influenzato lo sviluppo fetale. In termini di tazarotene topico, ci sono attualmente dati limitati sugli esiti della gravidanza dopo l’esposizione in utero. Sono necessari ulteriori case report e studi sui risultati per esplorare ulteriormente la sicurezza del tazarotene topico in gravidanza.
La chemerina è indotta nella steatosi epatica non alcolica e nel carcinoma epatocellulare correlato all’epatite B
Chemerin è protettivo nei modelli sperimentali di carcinoma epatocellulare (HCC). Degno di nota, l’mRNA e le proteine della chemerina sono stati ridotti nei tessuti HCC di pazienti asiatici con eziologia per lo più della malattia da epatite B. L’attuale studio ha tuttavia dimostrato che la proteina chemerina è stata indotta nei tessuti tumorali di pazienti europei con HCC con steatosi epatica non alcolica (NAFLD) e pazienti con eziologia della malattia poco chiara. Una regolazione simile è stata osservata nel virus dell’epatite B (HBV), ma non nel virus dell’epatite C (HCV), HCC correlato. L’apparente discrepanza tra la regolazione della chemerina nell’HBV-HCC ottenuta dal nostro studio e rapporti recenti ci ha portato ad utilizzare gli anticorpi chemerina applicati nei saggi precedenti. Questi anticorpi non sono stati in grado di rilevare ugualmente diverse isoforme di chemerina, che erano sovraespresse nelle cellule HepG2.
Tuttavia, l’uso di tutti gli anticorpi ha confermato la presenza di una maggiore proteina chemerina nell’HCC. La proteina chemerina era bassa nelle cellule Huh7 e PLC / PRF / 5, mentre le cellule HepG2 e Hep3B avevano una proteina chemerina simile agli epatociti umani primari. Inoltre, gli effetti antitumorali dei retinoidi nelle linee cellulari degli epatociti non includevano la sovraregolazione della chemerina, che è stata inizialmente scoperta come proteina indotta dal tazarotene nella pelle. Infine, i livelli di proteine del recettore delle chemerine, il recettore 1 simile alle chemochine (CMKLR1), sono diminuiti nei tessuti non virali e tendevano ad essere inferiori nei tessuti HBV-HCC, suggerendo una ridotta attività delle chemerine nei tumori. Per riassumere, il nostro lavoro ha mostrato una regolazione opposta di chemerina e CMKLR1 in NAFLD e HCC associato a HBV. Nell’HCV-HCC né la chemerina né il suo recettore sono stati modificati nei tessuti tumorali. I risultati attuali non supportano un ruolo critico dei livelli di proteine totali delle chemerine nell’HCC di eziologia non virale e virale. Di conseguenza, la proteina chemerina localizzata nel tumore non era associata alla classificazione delle metastasi del nodo tumorale.
Test di fotostabilità di un retinoide-tazarotene di terza generazione in presenza di assorbitori UV
L’esposizione di un farmaco all’irradiazione UV potrebbe influire sulle sue proprietà fisico-chimiche. Pertanto, il test di fotostabilità è essenziale per i farmaci somministrati per via topica. Il tazarotene, un retinoide di terza generazione selettivo per i recettori, è comunemente usato per curare l’acne vulgaris e la psoriasi. Nel presente studio è stata eseguita un’analisi approfondita della fotostabilità del tazarotene in soluzione etanolica in presenza di ossido di zinco e / o biossido di titanio e filtri UV di tipo benzofenone. Undici presunti prodotti sono stati derivati dalla degradazione fotocatalitica del tazarotene utilizzando la cromatografia liquida ad alte prestazioni-spettrometria di massa tandem e sono stati proposti percorsi di trasformazione.
Soft Tissue Tissue Slide (Skeletal Muscle-Normal) |
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| MBS154227-10um | MyBiosource | 10um | 210 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-Normal) |
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| MBS154227-4um | MyBiosource | 4um | 195 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-Normal) |
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| MBS154227-5x10um | MyBiosource | 5x10um | 920 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-Benign) |
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| MBS154290-10um | MyBiosource | 10um | 210 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-Benign) |
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| MBS154290-4um | MyBiosource | 4um | 195 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-Benign) |
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| MBS154290-5x10um | MyBiosource | 5x10um | 920 EUR |
Rat Skeletal Muscle Tissue Lysate |
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| IRTSKMTL100UG | Innovative research | each | 245 EUR |
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Description: Rat Skeletal Muscle Tissue Lysate |
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Rat Skeletal Muscle Tissue Lysate |
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| LYSATE0010 | BosterBio | 200ug | 180 EUR |
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Description: This cell lysate is prepared from rat skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C. |
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Rat Skeletal Muscle Tissue Lysate |
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| MBS8421547-01mg | MyBiosource | 0.1mg | 385 EUR |
Rat Skeletal Muscle Tissue Lysate |
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| MBS8421547-5x01mg | MyBiosource | 5x0.1mg | 1540 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-malignant) |
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| 12-345-10um | ProSci | 10 um | 241.8 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-malignant) |
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| 12-345-4um | ProSci | 4 um | 216.6 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-malignant) |
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| MBS154272-10um | MyBiosource | 10um | 210 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-malignant) |
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| MBS154272-4um | MyBiosource | 4um | 195 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-malignant) |
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| MBS154272-5x10um | MyBiosource | 5x10um | 920 EUR |
Human Skeletal Muscle Tissue Lysate |
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| IHUSKMTL100UG | Innovative research | each | 245 EUR |
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Description: Human Skeletal Muscle Tissue Lysate |
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Mouse Skeletal Muscle Tissue Lysate |
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| IMSSKMTL100UG | Innovative research | each | 245 EUR |
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Description: Mouse Skeletal Muscle Tissue Lysate |
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Mouse Skeletal Muscle Tissue Lysate |
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| LYSATE0021 | BosterBio | 200ug | 180 EUR |
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Description: This cell lysate is prepared from mouse skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C. |
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Mouse Skeletal Muscle Tissue Lysate |
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| MBS8420876-01mg | MyBiosource | 0.1mg | 385 EUR |
Mouse Skeletal Muscle Tissue Lysate |
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| MBS8420876-5x01mg | MyBiosource | 5x0.1mg | 1540 EUR |
Human Skeletal Muscle Tissue Lysate |
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| MBS8419499-01mg | MyBiosource | 0.1mg | 385 EUR |
Human Skeletal Muscle Tissue Lysate |
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| MBS8419499-5x01mg | MyBiosource | 5x0.1mg | 1540 EUR |
Bovine Skeletal Muscle Tissue Lysate |
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| IBOSKMTL100UG | Innovative research | each | 541 EUR |
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Description: Bovine Skeletal Muscle Tissue Lysate |
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Bovine Skeletal Muscle Tissue Lysate |
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| MBS136285-01mg | MyBiosource | 0.1mg | 745 EUR |
Bovine Skeletal Muscle Tissue Lysate |
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| MBS136285-5x01mg | MyBiosource | 5x0.1mg | 3165 EUR |
41225-2 RB MUSCLE TISSUE YG (1-kg) |
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| 41225-2 | Pel-Freez | 1 kg | 225 EUR |
41325-2 RB MUSCLE TISSUE MT FROZEN 1kg |
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| 41325-2 | Pel-Freez | 1 kg | 225 EUR |
Rat Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells |
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| 9-80281 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Diabetes Skeletal Muscle Tissue Lysate |
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| IHUSKMDIBTL100UG | Innovative research | each | 1413 EUR |
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Description: Human Diabetes Skeletal Muscle Tissue Lysate |
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Human Diabetes Skeletal Muscle Tissue Lysate |
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| MBS8419496-01mg | MyBiosource | 0.1mg | 1810 EUR |
Human Diabetes Skeletal Muscle Tissue Lysate |
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| MBS8419496-5x01mg | MyBiosource | 5x0.1mg | 7965 EUR |
Smooth muscle and striated muscle disease spectrum tissue array |
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| SO8011 | TissueArray | each | 414 EUR |
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Description: Smooth muscle and striated muscle disease spectrum tissue array, including TNM and clinical stage, 80 cases /80 cores |
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Human Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells |
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| 9-80092 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells |
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| 9-80189 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells |
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| 9-80280 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells |
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| 9-80091 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells |
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| 9-80188 | CHI Scientific | 1 x 100 ml | Ask for price |
Monkey Cynomolgus Skeletal Muscle Tissue Lysate |
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| IMNCYSKMTL100UG | Innovative research | each | 541 EUR |
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Description: Monkey Cynomolgus Skeletal Muscle Tissue Lysate |
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Monkey Cynomolgus Skeletal Muscle Tissue Lysate |
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| MBS8420209-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Skeletal Muscle |
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| T1236171Dia | Biochain | 5 slides | 523 EUR |
cDNA - Dog Normal Tissue: Skeletal Muscle |
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| C1734171 | Biochain | 40 reactions | 424 EUR |
cDNA - Rat Normal Tissue: Skeletal Muscle |
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| C1434171 | Biochain | 40 reactions | 424 EUR |
Rhabdomyosarcoma with striated muscle tissue array |
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| SO2082b | TissueArray | each | 546 EUR |
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Description: Rhabdomyosarcoma with striated muscle tissue array, including TNM and clinical stage, 104 cases/208 cores, replacing SO2082a |
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Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array |
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| SO2081 | TissueArray | each | 474 EUR |
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Description: Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array, 104 cases/208 cores |
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cDNA - Human Tumor Tissue: Skeletal Muscle |
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| C1235171-10 | Biochain | 10 reactions | 301 EUR |
Rat Skeletal Muscle Whole tissue lysate |
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| RAL-1467 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Skeletal Muscle |
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| T2236171Dia | Biochain | 5 slides | 262 EUR |
cDNA - Mouse Normal Tissue: Skeletal Muscle |
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| C1334171 | Biochain | 40 reactions | 424 EUR |
Human Skeletal Muscle Fetal Tissue Lysate |
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| IHUSKMFSTL100UG | Innovative research | each | 541 EUR |
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Description: Human Skeletal Muscle Fetal Tissue Lysate |
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Mouse Skeletal Muscle Whole tissue lysate |
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| MAL-1407 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Rat Muscle OptiTDS1: Tissue Dissociation System |
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| 4-28280 | CHI Scientific | 1 Kit | Ask for price |
Rat Muscle OptiTDS2: Tissue Dissociation System |
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| 4-28281 | CHI Scientific | 1 Kit | Ask for price |
Total RNA - Rat Normal Tissue: Skeletal Muscle |
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| R1434171-50 | Biochain | 50 ug | 156 EUR |
Human Muscle OptiTDS1: Tissue Dissociation System |
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| 4-28091 | CHI Scientific | 1 Kit | Ask for price |
Human Muscle OptiTDS2: Tissue Dissociation System |
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| 4-28092 | CHI Scientific | 1 Kit | Ask for price |
Mouse Muscle OptiTDS1: Tissue Dissociation System |
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| 4-28188 | CHI Scientific | 1 Kit | Ask for price |
Mouse Muscle OptiTDS2: Tissue Dissociation System |
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| 4-28189 | CHI Scientific | 1 Kit | Ask for price |
Genomic DNA - Rat Normal Tissue: Skeletal Muscle |
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| D1434171 | Biochain | 100 ug | 329 EUR |
Total RNA - Mouse Normal Tissue: Skeletal Muscle |
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| R1334171-50 | Biochain | 50 ug | 156 EUR |
cDNA - Human Adult Normal Tissue: Skeletal Muscle |
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| C1234171 | Biochain | 40 reactions | 424 EUR |
Genomic DNA - Mouse Normal Tissue: Skeletal Muscle |
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| D1334171 | Biochain | 100 ug | 329 EUR |
cDNA - Monkey (Rhesus) Normal Tissue: Skeletal Muscle |
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| C1534171 | Biochain | 40 reactions | 481 EUR |
Total Protein - Human Tumor Tissue: Skeletal Muscle |
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| P1235171 | Biochain | 1 mg | 357 EUR |
Tissue, Total Protein, Human Tumor, Skeletal Muscle |
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| MBS657457-1mg | MyBiosource | 1mg | 680 EUR |
Tissue, Total Protein, Human Tumor, Skeletal Muscle |
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| MBS657457-5x1mg | MyBiosource | 5x1mg | 2835 EUR |
Total Protein - Mouse Normal Tissue: Skeletal Muscle |
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| P1334171 | Biochain | 1 mg | 216 EUR |
cDNA - Human Diabetic Diseased Tissue: Skeletal Muscle |
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| C1236171Dia | Biochain | 40 reactions | 802 EUR |
cDNA - Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle |
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| C1534171-Cy | Biochain | 40 reactions | 481 EUR |
Human Liver Cirrhosis Muscle Diaphragm Tissue Lysate |
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| IHUMSCDPHCIRTL100UG | Innovative research | each | 1413 EUR |
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Description: Human Liver Cirrhosis Muscle Diaphragm Tissue Lysate |
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Human Liver Cirrhosis Muscle Diaphragm Tissue Lysate |
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| MBS8415535-01mg | MyBiosource | 0.1mg | 1810 EUR |
Human Liver Cirrhosis Muscle Diaphragm Tissue Lysate |
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| MBS8415535-5x01mg | MyBiosource | 5x0.1mg | 7965 EUR |
Total RNA - Human Adult Normal Tissue: Skeletal Muscle |
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| R1234171-50 | Biochain | 50 ug | 221 EUR |
Total RNA - Human Adult Normal Tissue: Muscle: Diaphragm |
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| R1234169-10 | Biochain | 10 ug | 221 EUR |
Total RNA - Monkey (Rhesus) Normal Tissue: Skeletal Muscle |
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| R1534171-50 | Biochain | 50 ug | 229 EUR |
Human Adult Skeletal Muscle (Normal) Whole tissue lysate |
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| HAL-1375 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Monkey (Cyno.) Normal Skeletal Muscle Whole tissue lysate |
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| MCL-1197 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Total Protein - Human Adult Normal Tissue: Skeletal Muscle |
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| P1234171 | Biochain | 1 mg | 216 EUR |
Tissue, Total Protein, Mouse Adult Normal, Skeletal Muscle |
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| MBS657016-1mg | MyBiosource | 1mg | 565 EUR |
Tissue, Total Protein, Mouse Adult Normal, Skeletal Muscle |
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| MBS657016-5x1mg | MyBiosource | 5x1mg | 2315 EUR |
Tissue, Total Protein, Human Adult Normal, Skeletal Muscle |
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| MBS657322-1mg | MyBiosource | 1mg | 565 EUR |
Tissue, Total Protein, Human Adult Normal, Skeletal Muscle |
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| MBS657322-5x1mg | MyBiosource | 5x1mg | 2315 EUR |
Monkey (Rhesus) Normal Skeletal Muscle Whole tissue lysate |
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| MRL-1247 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Frozen Tissue Section - Human Adult Normal: Skeletal Muscle |
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| T1234171 | Biochain | 5 slides | 377 EUR |
Tissue, Section, Human Adult Normal, Skeletal Muscle (Frozen) |
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| MBS640631-5Sections | MyBiosource | 5Sections | 635 EUR |
Tissue, Section, Human Adult Normal, Skeletal Muscle (Frozen) |
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| MBS640631-5x5Sections | MyBiosource | 5x5Sections | 2640 EUR |
Total RNA - Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle |
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| R1534171-Cy | Biochain | 50 ug | 229 EUR |
Membrane Protein - Human Adult Normal Tissue: Skeletal Muscle |
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| P3234171 | Biochain | 0.1 mg | 311 EUR |
Paraffin Tissue Section - Human Adult Normal: Skeletal Muscle |
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| T2234171 | Biochain | 5 slides | 204 EUR |
Tissue, Section, Human Adult Normal, Skeletal Muscle (Paraffin) |
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| MBS640137-5Sections | MyBiosource | 5Sections | 460 EUR |
Tissue, Section, Human Adult Normal, Skeletal Muscle (Paraffin) |
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| MBS640137-5x5Sections | MyBiosource | 5x5Sections | 1925 EUR |
Tissue, Membrane Protein, Human Adult Normal, Skeletal Muscle |
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| MBS639871-01mg | MyBiosource | 0.1mg | 570 EUR |
Tissue, Membrane Protein, Human Adult Normal, Skeletal Muscle |
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| MBS639871-5x01mg | MyBiosource | 5x0.1mg | 2345 EUR |
Total RNA - Human Adult Normal Tissue: Heart: Papilla Muscle |
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| R1234132-10 | Biochain | 10 ug | 221 EUR |
Tissue, Total Protein, Human Disease, Diabetes, Skeletal Muscle |
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| MBS657193-1mg | MyBiosource | 1mg | 820 EUR |
Tissue, Total Protein, Human Disease, Diabetes, Skeletal Muscle |
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| MBS657193-5x1mg | MyBiosource | 5x1mg | 3470 EUR |
Total Protein - Human Diabetic Diseased Tissue: Skeletal Muscle |
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| P1236171Dia | Biochain | 1 mg | 542 EUR |
Tissue, Section, Human Disease, Diabetes, Skeletal Muscle (Frozen) |
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| MBS640417-5Slides | MyBiosource | 5Slides | 755 EUR |
Tissue, Section, Human Disease, Diabetes, Skeletal Muscle (Frozen) |
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| MBS640417-5x5Slides | MyBiosource | 5x5Slides | 3170 EUR |
Tissue, Membrane Protein, Human Disease, Diabetes, Skeletal Muscle |
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| MBS639800-01mg | MyBiosource | 0.1mg | 695 EUR |
Tissue, Membrane Protein, Human Disease, Diabetes, Skeletal Muscle |
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| MBS639800-5x01mg | MyBiosource | 5x0.1mg | 2915 EUR |
Tissue, Section, Human Disease, Diabetes, Skeletal Muscle (Paraffin) |
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| MBS640643-5Slides | MyBiosource | 5Slides | 510 EUR |
Tissue, Section, Human Disease, Diabetes, Skeletal Muscle (Paraffin) |
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| MBS640643-5x5Slides | MyBiosource | 5x5Slides | 2145 EUR |
Total Protein - Human Adult Normal Tissue: Heart: Papilla Muscle |
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| P1234132 | Biochain | 1 mg | 590 EUR |
Tissue, Total Protein, Human Adult Normal, Heart, Papilla Muscle |
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| MBS657154-1mg | MyBiosource | 1mg | 860 EUR |
Tissue, Total Protein, Human Adult Normal, Heart, Papilla Muscle |
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| MBS657154-5x1mg | MyBiosource | 5x1mg | 3640 EUR |
Tissue, Total RNA, Rat Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638559-005mg | MyBiosource | 0.05mg | 435 EUR |
Tissue, Total RNA, Rat Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638559-5x005mg | MyBiosource | 5x0.05mg | 1735 EUR |
Human Soft Tissue Slide (Skeletal Muscle Normal) (5 slides/pk) |
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| HTS-12341 | Alpha Diagnostics | 1 pk | 343.2 EUR |
Human Soft Tissue Slide (Skeletal Muscle Benign) (5 slides/pk) |
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| HTS-12343 | Alpha Diagnostics | 1 pk | 343.2 EUR |
Skeletal Muscle Tissue Slides, Normal Rat Paraffin Sections, 5 slides/pack |
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| TS-R5410 | IHC World | - | 145 EUR |
Paraffin Tissue Section - Human Adult Normal: Heart: Papilla Muscle |
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| T2234132 | Biochain | 5 slides | 204 EUR |
Tissue, Section, Human Adult Normal, Heart, Papilla Muscle (Paraffin) |
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| MBS640350-5Sections | MyBiosource | 5Sections | 460 EUR |
Tissue, Section, Human Adult Normal, Heart, Papilla Muscle (Paraffin) |
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| MBS640350-5x5Sections | MyBiosource | 5x5Sections | 1925 EUR |
Tissue, Total RNA, Mouse, Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638546-005mg | MyBiosource | 0.05mg | 435 EUR |
Tissue, Total RNA, Mouse, Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638546-5x005mg | MyBiosource | 5x0.05mg | 1735 EUR |
Tissue, Total RNA, Human Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638548-005mg | MyBiosource | 0.05mg | 495 EUR |
Tissue, Total RNA, Human Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638548-5x005mg | MyBiosource | 5x0.05mg | 1995 EUR |
Tissue, Genomic DNA, Rat Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS654525-01mg | MyBiosource | 0.1mg | 575 EUR |
Tissue, Genomic DNA, Rat Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS654525-5x01mg | MyBiosource | 5x0.1mg | 2440 EUR |
Tissue, Total RNA, Human Adult Normal, Muscle, Diaphragm, BioGenomics |
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| MBS638673-001mg | MyBiosource | 0.01mg | 485 EUR |
Tissue, Total RNA, Human Adult Normal, Muscle, Diaphragm, BioGenomics |
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| MBS638673-5x001mg | MyBiosource | 5x0.01mg | 1960 EUR |
Tissue cDNA, First Strand, Human Tumor, Skeletal Muscle, BioGenomics |
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| MBS652570-10Tests | MyBiosource | 10Tests | 570 EUR |
Tissue cDNA, First Strand, Human Tumor, Skeletal Muscle, BioGenomics |
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| MBS652570-5x10Tests | MyBiosource | 5x10Tests | 2345 EUR |
Human Soft Tissue Slide (Skeletal Muscle Malignant) (5 slides/pk) |
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| HTS-12345 | Alpha Diagnostics | 1 pk | 343.2 EUR |
Skeletal Muscle Tissue Slides, Normal Human Paraffin Sections, 5 slides/pack |
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| TS-H5019 | IHC World | - | 145 EUR |
Skeletal Muscle Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack |
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| TS-M5208 | IHC World | - | 145 EUR |
Tissue, Genomic DNA, Human Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS654357-01mg | MyBiosource | 0.1mg | 575 EUR |
Tissue, Genomic DNA, Human Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS654357-5x01mg | MyBiosource | 5x0.1mg | 2440 EUR |
Tissue, Genomic DNA, Mouse Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS654457-01mg | MyBiosource | 0.1mg | 575 EUR |
Tissue, Genomic DNA, Mouse Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS654457-5x01mg | MyBiosource | 5x0.1mg | 2440 EUR |
Total RNA - Human Adult Normal Tissue 5 Donor Pool: Skeletal Muscle |
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| R1234171-P | Biochain | 50 ug | 443 EUR |
Rat Bladder Tissue Preparation Buffer 3: Normal Smooth Muscle Cells |
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| 9-80215 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells |
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| 9-80288 | CHI Scientific | 1 x 100 ml | Ask for price |
Tissue cDNA, First Strand, Rat Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS651951-40Tests | MyBiosource | 40Tests | 680 EUR |
Tissue cDNA, First Strand, Rat Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS651951-5x40Tests | MyBiosource | 5x40Tests | 2835 EUR |
Tissue Set, BioAssay, DNA, RNA, Protein, Rat Adult Normal, Skeletal Muscle |
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| MBS640974-1Set | MyBiosource | 1Set | 650 EUR |
Tissue Set, BioAssay, DNA, RNA, Protein, Rat Adult Normal, Skeletal Muscle |
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| MBS640974-5x1Set | MyBiosource | 5x1Set | 2970 EUR |
Human Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells |
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| 9-80100 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells |
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| 9-80198 | CHI Scientific | 1 x 100 ml | Ask for price |
Tissue, Total RNA, Monkey (Rhesus) Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638519-005mg | MyBiosource | 0.05mg | 485 EUR |
Tissue, Total RNA, Monkey (Rhesus) Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638519-5x005mg | MyBiosource | 5x0.05mg | 1960 EUR |
Tissue cDNA, First Strand, Canine Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS652356-40Tests | MyBiosource | 40Tests | 680 EUR |
Tissue cDNA, First Strand, Canine Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS652356-5x40Tests | MyBiosource | 5x40Tests | 2835 EUR |
Tissue cDNA, First Strand, Human Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS652565-40Tests | MyBiosource | 40Tests | 680 EUR |
Il processo di degradazione ha interessato principalmente la porzione 4,4-dimetil-3,4-diidro-2H-tiopirano. I frammenti più suscettibili all’ossidazione erano i gruppi metilici e l’atomo di zolfo. Inoltre, in presenza di sulisobenzone, sotto irradiazione UV, il tazarotene è stato sottoposto ad un processo di degradazione, che ha portato a due prodotti di fotodecomposizione. Studi in silico eseguiti da OSIRIS Property Explorer hanno dimostrato che cinque dei prodotti di degradazione potrebbero essere dannosi in termini di effetti riproduttivi, che sono associati a 3,4-diidro-6-metil-2H-1-benzotiopirano 1,1-diossido, mentre uno di loro ha dimostrato una potenziale attività irritante. Le proprietà citotossiche dei prodotti di degradazione del tazarotene sono state valutate mediante dosaggio MTT su un pannello di cellule cancerose umane aderenti. L’inibizione della crescita dipendente dal tempo e dalla concentrazione è stata evidenziata nelle linee cellulari di cancro dell’ovaio (A2780) e della mammella (MDA-MB-231). La potenziale implicazione dei risultati della presente ricerca richiede ulteriori studi riguardanti principalmente la fotostabilità del tazarotene nelle formulazioni topiche.
