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Uso di tazarotene topico per il trattamento dell'acne vulgaris in gravidanza: una revisione della letteratura

Uso di tazarotene topico per il trattamento dell’acne vulgaris in gravidanza: una revisione della letteratura

Posted on Dicembre 4, 2020Dicembre 4, 2020 By andrea Nessun commento su Uso di tazarotene topico per il trattamento dell’acne vulgaris in gravidanza: una revisione della letteratura

Una preoccupazione per il crescente uso di farmaci da prescrizione durante la gravidanza è il rischio teratogeno. Questo rischio non è determinato per la maggior parte dei farmaci approvati negli Stati Uniti (USA) dal 2000 al 2010. L’acne e la psoriasi sono malattie croniche che si verificano tipicamente durante l’età fertile e poiché i retinoidi topici sono raccomandati sia per il trattamento dell’acne che per la psoriasi, è è possibile che le donne siano esposte a un retinoide topico durante la gravidanza. Gli studi di farmacocinetica mostrano un’esposizione sistemica relativamente bassa ai retinoidi topici, ma i livelli di esposizione che potrebbero portare a teratogenicità nell’uomo non sono noti. Il tazarotene, un retinoide topico, è stato approvato dalla Food and Drug Administration (FDA) statunitense sia per l’acne che per la psoriasi utilizzando i dati di farmacocinetica degli studi sulla psoriasi, che hanno stimato i dati basati sull’uso del tazarotene fino al 20% della superficie corporea.

Pertanto, sia in base all’etichettatura della gravidanza precedente che in quella attuale della FDA, il tazarotene non è raccomandato per l’uso durante la gravidanza. L’obiettivo di questa revisione della letteratura era fornire un contesto storico per la regola di etichettatura della gravidanza per il tazarotene rispetto ad altri retinoidi approvati e raccogliere i dati disponibili sugli esiti della gravidanza correlati a tazarotene e retinoidi. Sebbene vi siano segnalazioni di casi di esposizione topica alla tretinoina e all’adapalene in utero, non è chiaro se entrambe abbiano influenzato lo sviluppo fetale. In termini di tazarotene topico, ci sono attualmente dati limitati sugli esiti della gravidanza dopo l’esposizione in utero. Sono necessari ulteriori case report e studi sui risultati per esplorare ulteriormente la sicurezza del tazarotene topico in gravidanza.

La chemerina è indotta nella steatosi epatica non alcolica e nel carcinoma epatocellulare correlato all’epatite B

Chemerin è protettivo nei modelli sperimentali di carcinoma epatocellulare (HCC). Degno di nota, l’mRNA e le proteine ​​della chemerina sono stati ridotti nei tessuti HCC di pazienti asiatici con eziologia per lo più della malattia da epatite B. L’attuale studio ha tuttavia dimostrato che la proteina chemerina è stata indotta nei tessuti tumorali di pazienti europei con HCC con steatosi epatica non alcolica (NAFLD) e pazienti con eziologia della malattia poco chiara. Una regolazione simile è stata osservata nel virus dell’epatite B (HBV), ma non nel virus dell’epatite C (HCV), HCC correlato. L’apparente discrepanza tra la regolazione della chemerina nell’HBV-HCC ottenuta dal nostro studio e rapporti recenti ci ha portato ad utilizzare gli anticorpi chemerina applicati nei saggi precedenti. Questi anticorpi non sono stati in grado di rilevare ugualmente diverse isoforme di chemerina, che erano sovraespresse nelle cellule HepG2.

Tuttavia, l’uso di tutti gli anticorpi ha confermato la presenza di una maggiore proteina chemerina nell’HCC. La proteina chemerina era bassa nelle cellule Huh7 e PLC / PRF / 5, mentre le cellule HepG2 e Hep3B avevano una proteina chemerina simile agli epatociti umani primari. Inoltre, gli effetti antitumorali dei retinoidi nelle linee cellulari degli epatociti non includevano la sovraregolazione della chemerina, che è stata inizialmente scoperta come proteina indotta dal tazarotene nella pelle. Infine, i livelli di proteine ​​del recettore delle chemerine, il recettore 1 simile alle chemochine (CMKLR1), sono diminuiti nei tessuti non virali e tendevano ad essere inferiori nei tessuti HBV-HCC, suggerendo una ridotta attività delle chemerine nei tumori. Per riassumere, il nostro lavoro ha mostrato una regolazione opposta di chemerina e CMKLR1 in NAFLD e HCC associato a HBV. Nell’HCV-HCC né la chemerina né il suo recettore sono stati modificati nei tessuti tumorali. I risultati attuali non supportano un ruolo critico dei livelli di proteine ​​totali delle chemerine nell’HCC di eziologia non virale e virale. Di conseguenza, la proteina chemerina localizzata nel tumore non era associata alla classificazione delle metastasi del nodo tumorale.

Uso di tazarotene topico per il trattamento dell'acne vulgaris in gravidanza: una revisione della letteratura
Uso di tazarotene topico per il trattamento dell’acne vulgaris in gravidanza: una revisione della letteratura

Test di fotostabilità di un retinoide-tazarotene di terza generazione in presenza di assorbitori UV

L’esposizione di un farmaco all’irradiazione UV potrebbe influire sulle sue proprietà fisico-chimiche. Pertanto, il test di fotostabilità è essenziale per i farmaci somministrati per via topica. Il tazarotene, un retinoide di terza generazione selettivo per i recettori, è comunemente usato per curare l’acne vulgaris e la psoriasi. Nel presente studio è stata eseguita un’analisi approfondita della fotostabilità del tazarotene in soluzione etanolica in presenza di ossido di zinco e / o biossido di titanio e filtri UV di tipo benzofenone. Undici presunti prodotti sono stati derivati ​​dalla degradazione fotocatalitica del tazarotene utilizzando la cromatografia liquida ad alte prestazioni-spettrometria di massa tandem e sono stati proposti percorsi di trasformazione.

Soft Tissue Tissue Slide (Skeletal Muscle-Benign)

12-343-4um ProSci 4 um 216.6 EUR

Soft Tissue Tissue Slide (Skeletal Muscle-malignant)

12-345-10um ProSci 10 um 241.8 EUR

Soft Tissue Tissue Slide (Skeletal Muscle-malignant)

12-345-4um ProSci 4 um 216.6 EUR

Rat Skeletal Muscle Tissue Lysate

LYSATE0010 BosterBio 200ug 180 EUR
Description: This cell lysate is prepared from rat skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C.

Mouse Skeletal Muscle Tissue Lysate

LYSATE0021 BosterBio 200ug 180 EUR
Description: This cell lysate is prepared from mouse skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C.

Paraffin Tissue Section - Human Diabetic Tissue: Skeletal Muscle

T2236171Dia Biochain 5 slides 308.4 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Human Diabetic Tissue: Skeletal Muscle

T1236171Dia Biochain 5 slides 558 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Smooth muscle and striated muscle disease spectrum tissue array

SO8011 TissueArray each 414 EUR
Description: Smooth muscle and striated muscle disease spectrum tissue array, including TNM and clinical stage, 80 cases /80 cores

Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array

SO2081 TissueArray each 474 EUR
Description: Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array, 104 cases/208 cores

Actin, Rabbit Muscle

P1246-1000 Biovision each 274.8 EUR

Actin, Rabbit Muscle

P1246-500 Biovision each 196.8 EUR

Human Muscle OptiTDS1: Tissue Dissociation System

4-28091 CHI Scientific 1 Kit Ask for price

Human Muscle OptiTDS2: Tissue Dissociation System

4-28092 CHI Scientific 1 Kit Ask for price

Mouse Muscle OptiTDS1: Tissue Dissociation System

4-28188 CHI Scientific 1 Kit Ask for price

Mouse Muscle OptiTDS2: Tissue Dissociation System

4-28189 CHI Scientific 1 Kit Ask for price

Rat Muscle OptiTDS1: Tissue Dissociation System

4-28280 CHI Scientific 1 Kit Ask for price

Rat Muscle OptiTDS2: Tissue Dissociation System

4-28281 CHI Scientific 1 Kit Ask for price

Mouse Skeletal Muscle Whole tissue lysate

MAL-1407 Alpha Diagnostics 1 mg 628.8 EUR

Rat Skeletal Muscle Whole tissue lysate

RAL-1467 Alpha Diagnostics 1 mg 628.8 EUR

Rhabdomyosarcoma with striated muscle tissue array

SO2082b TissueArray each 546 EUR
Description: Rhabdomyosarcoma with striated muscle tissue array, including TNM and clinical stage, 104 cases/208 cores, replacing SO2082a

Human Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells

9-80091 CHI Scientific 1 x 100 ml Ask for price

Human Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells

9-80092 CHI Scientific 1 x 100 ml Ask for price

Mouse Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells

9-80188 CHI Scientific 1 x 100 ml Ask for price

Mouse Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells

9-80189 CHI Scientific 1 x 100 ml Ask for price

Rat Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells

9-80280 CHI Scientific 1 x 100 ml Ask for price

Rat Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells

9-80281 CHI Scientific 1 x 100 ml Ask for price

cDNA from Human Tumor Tissue: Skeletal Muscle

C1235171-10 Biochain 10 reactions 338.4 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Diabetic Tissue: Skeletal Muscle

C1236171Dia Biochain 40 reactions 801.6 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Skeletal Muscle

C1334171 Biochain 40 reactions 451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Skeletal Muscle

C1434171 Biochain 40 reactions 451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Skeletal Muscle

C1734171 Biochain 40 reactions 451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Aldolase (Rabbit Muscle) Antibody

abx022821-50mg Abbexa 50 mg 1262.4 EUR

Genomic DNA from Mouse Normal Tissue: Skeletal Muscle

D1334171 Biochain 100 ug 338.4 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Rat Normal Tissue: Skeletal Muscle

D1434171 Biochain 100 ug 338.4 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Skeletal Muscle

C1234171 Biochain 40 reactions 451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Skeletal Muscle

C1534171 Biochain 40 reactions 451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle

C1534171-Cy Biochain 40 reactions 451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Monkey (Cyno.) Normal Skeletal Muscle Whole tissue lysate

MCL-1197 Alpha Diagnostics 1 mg 628.8 EUR

Monkey (Rhesus) Normal Skeletal Muscle Whole tissue lysate

MRL-1247 Alpha Diagnostics 1 mg 628.8 EUR

Total Protein from Human Tumor Tissue: Skeletal Muscle

P1235171 Biochain 1 mg 384 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Human Diabetic Tissue: Skeletal Muscle

P1236171Dia Biochain 1 mg 553.2 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Mouse Normal Tissue: Skeletal Muscle

P1334171 Biochain 1 mg 256.8 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Human Adult Skeletal Muscle (Normal) Whole tissue lysate

HAL-1375 Alpha Diagnostics 1 mg 628.8 EUR

Paraffin Tissue Section - Human Adult Normal: Skeletal Muscle

T2234171 Biochain 5 slides 253.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Human Adult Normal: Skeletal Muscle

T1234171 Biochain 5 slides 418.8 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Total RNA from Mouse Normal Tissue: Skeletal Muscle

R1334171-50 Biochain 50 ug 182.4 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Skeletal Muscle

R1434171-50 Biochain 50 ug 182.4 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Rabbit Liver Tissue Lysate

30R-AL003 Fitzgerald 150 ug 302.4 EUR
Description: Fresh tissue lysate prepared from rabbit liver

Tissue Factor Rabbit mAb

A4395-100ul Abclonal 100 ul 492 EUR

Tissue Factor Rabbit mAb

A4395-200ul Abclonal 200 ul 685.2 EUR

Tissue Factor Rabbit mAb

A4395-20ul Abclonal 20 ul 265.2 EUR

Tissue Factor Rabbit mAb

A4395-50ul Abclonal 50 ul 344.4 EUR

Purified (>95%) muscle Actin Protein from muscle (rabbit/bovine)

ACTB15-N-1 Alpha Diagnostics 1 mg 489.6 EUR

Rabbit Skeletal Muscle Troponin-C

7-06205 CHI Scientific 1mg Ask for price

Rabbit Skeletal Muscle Troponin-C

7-06206 CHI Scientific 5mg Ask for price

Rabbit Skeletal Muscle Troponin-C

7-06207 CHI Scientific 10mg Ask for price

alpha Actin (Skeletal Muscle) (Rabbit)

30R-3107 Fitzgerald 1 mg 308.4 EUR
Description: Purified native alpha Actin (Skeletal Muscle) (Rabbit)

Rabbit MUSCLE ACETONE POWDER 10g

41995-2 Pel-Freez 10g 328.56 EUR

Actin, pyrene labeled, Rabbit Muscle

M1319-1000 Biovision each 222 EUR

Actin, pyrene labeled, Rabbit Muscle

M1319-500 Biovision each 183.6 EUR

Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I

T6834700-G01-1 Biochain 1 slide 309.6 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I

T6834700-G01-5 Biochain 5 slides 985.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I

T6834700-G02-1 Biochain 1 slide 309.6 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I

T6834700-G02-5 Biochain 5 slides 985.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Total Protein from Human Adult Normal Tissue: Skeletal Muscle

P1234171 Biochain 1 mg 256.8 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Membrane Protein from Human Adult Normal Tissue: Skeletal Muscle

P3234171 Biochain 0.1 mg 342 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Paraffin Tissue Section - Human Adult Normal: Heart: Papilla Muscle

T2234132 Biochain 5 slides 253.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Total RNA from Human Adult Normal Tissue: Muscle: Diaphragm

R1234169-10 Biochain 10 ug 232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Skeletal Muscle

R1234171-50 Biochain 50 ug 213.6 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Monkey (Rhesus) Normal Tissue: Skeletal Muscle

R1534171-50 Biochain 50 ug 232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle

R1534171-Cy Biochain 50 ug 232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Rabbit Tissue Factor (TF) Protein

20-abx069317 Abbexa
  • 744.00 EUR
  • 326.40 EUR
  • 2230.80 EUR
  • 878.40 EUR
  • 543.60 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rabbit Tissue Factor ELISA kit

E04T0037-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tissue Factor ELISA kit

E04T0037-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tissue Factor ELISA kit

E04T0037-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tissue Transglutaminase ELISA kit

E04T0766-192T BlueGene 192 tests 1524 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Tissue Transglutaminase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tissue Transglutaminase ELISA kit

E04T0766-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Tissue Transglutaminase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tissue Transglutaminase ELISA kit

E04T0766-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Tissue Transglutaminase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tissue factor ELISA Kit

ELA-E0524Rb Lifescience Market 96 Tests 1113.6 EUR

alpha smooth muscle actin Rabbit pAb

A0957-100ul Abclonal 100 ul 460.8 EUR

alpha smooth muscle actin Rabbit pAb

A0957-200ul Abclonal 200 ul Ask for price

alpha smooth muscle actin Rabbit pAb

A0957-20ul Abclonal 20 ul Ask for price

alpha smooth muscle actin Rabbit pAb

A0957-50ul Abclonal 50 ul 318 EUR

alpha smooth muscle actin Rabbit pAb

A1011-100ul Abclonal 100 ul 369.6 EUR

alpha smooth muscle actin Rabbit pAb

A1011-200ul Abclonal 200 ul 550.8 EUR

alpha smooth muscle actin Rabbit pAb

A1011-20ul Abclonal 20 ul 219.6 EUR

alpha smooth muscle actin Rabbit pAb

A1011-50ul Abclonal 50 ul 267.6 EUR

Rabbit MUSCLE ACETONE POWDER (1-g)

41995-1 Pel-Freez 1g 144.55 EUR

Troponin I protein (Skeletal Muscle) (Rabbit)

30-1015 Fitzgerald 100 ug 582 EUR
Description: Purified native Rabbit Troponin I protein (Skeletal Muscle)

Troponin C protein (Skeletal Muscle) (Rabbit)

30-1020 Fitzgerald 1 mg 1059.6 EUR
Description: Purified native Rabbit Troponin C protein (Skeletal Muscle)

Rabbit Enolase, Muscle Specific (MSE) Protein

20-abx066421 Abbexa
  • 794.40 EUR
  • 326.40 EUR
  • 2448.00 EUR
  • 944.40 EUR
  • 577.20 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

alpha smooth muscle actin Rabbit pAb

A7248-100ul Abclonal 100 ul 369.6 EUR

alpha smooth muscle actin Rabbit pAb

A7248-200ul Abclonal 200 ul 550.8 EUR

alpha smooth muscle actin Rabbit pAb

A7248-20ul Abclonal 20 ul 219.6 EUR

alpha smooth muscle actin Rabbit pAb

A7248-50ul Abclonal 50 ul 267.6 EUR

alpha smooth muscle Actin Rabbit mAb

A17910 Abclonal 20 μL 18 EUR

alpha smooth muscle Actin Rabbit mAb

A17910-100ul Abclonal 100 ul 492 EUR

alpha smooth muscle Actin Rabbit mAb

A17910-200ul Abclonal 200 ul 685.2 EUR

alpha smooth muscle Actin Rabbit mAb

A17910-20ul Abclonal 20 ul 265.2 EUR

alpha smooth muscle Actin Rabbit mAb

A17910-50ul Abclonal 50 ul 344.4 EUR

Rabbit Phosphofructokinase, Muscle (PFKM) ELISA Kit

abx363038-96tests Abbexa 96 tests 990 EUR

Rabbit Skeletal Muscle Troponin-C Protein

20-abx260177 Abbexa
  • 1646.40 EUR
  • 393.60 EUR
  • 1028.40 EUR
  • 10 mg
  • 1 mg
  • 5 mg

Rabbit Creatine Kinase, Muscle (CKM) Protein

20-abx653071 Abbexa
  • 777.60 EUR
  • 326.40 EUR
  • 2397.60 EUR
  • 927.60 EUR
  • 560.40 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rabbit Anti Actin (Muscle) Polyclonal Antibody

CPBT-68162RA Creative Diagnostics 0.5 ml 1057.2 EUR

Rabbit Glycogen Phosphorylase, Muscle ELISA kit

E04P0170-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Glycogen Phosphorylase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Glycogen Phosphorylase, Muscle ELISA kit

E04P0170-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Glycogen Phosphorylase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Glycogen Phosphorylase, Muscle ELISA kit

E04P0170-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Glycogen Phosphorylase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Eye muscle antibody ELISA kit

E04E0148-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Eye muscle antibody ELISA kit

E04E0148-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Eye muscle antibody ELISA kit

E04E0148-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Creatine Kinase, Muscle ELISA kit

E04C0400-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Creatine Kinase, Muscle ELISA kit

E04C0400-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Creatine Kinase, Muscle ELISA kit

E04C0400-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Cofilin 2, Muscle ELISA kit

E04C0470-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Cofilin 2, Muscle ELISA kit

E04C0470-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Cofilin 2, Muscle ELISA kit

E04C0470-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Phosphofructocinase Muscle(PFKM) ELISA Kit

QY-E30328 Qayee Biotechnology 96T 448.8 EUR

Creatine Kinase (CK/CPK), Rabbit Muscle

P1301-1 Biovision each 164.4 EUR

Creatine Kinase (CK/CPK), Rabbit Muscle

P1301-25 Biovision each 679.2 EUR

J Young Schlenk Cap B19

NMR1107 Scientific Laboratory Supplies EACH 16.18 EUR

J Young Schlenk Cap B24

NMR1108 Scientific Laboratory Supplies EACH 16.92 EUR

J Young Schlenk Cap B29

NMR1109 Scientific Laboratory Supplies EACH 17.69 EUR

Human Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells

9-80100 CHI Scientific 1 x 100 ml Ask for price

Mouse Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells

9-80198 CHI Scientific 1 x 100 ml Ask for price

Rat Bladder Tissue Preparation Buffer 3: Normal Smooth Muscle Cells

9-80215 CHI Scientific 1 x 100 ml Ask for price

Rat Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells

9-80288 CHI Scientific 1 x 100 ml Ask for price

Total Protein from Human Adult Normal Tissue: Heart: Papilla Muscle

P1234132 Biochain 1 mg 596.4 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Human Soft Tissue Slide (Skeletal Muscle Normal) (5 slides/pk)

HTS-12341 Alpha Diagnostics 1 pk 343.2 EUR

Human Soft Tissue Slide (Skeletal Muscle Benign) (5 slides/pk)

HTS-12343 Alpha Diagnostics 1 pk 343.2 EUR

Human Soft Tissue Slide (Skeletal Muscle Malignant) (5 slides/pk)

HTS-12345 Alpha Diagnostics 1 pk 343.2 EUR

Total RNA from Human Adult Normal Tissue: Heart: Papilla Muscle

R1234132-10 Biochain 10 ug 232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Rabbit PSOAS MUSCLE YG FROZEN 1 EA

41217-1 Pel-Freez 1 Each 216.34 EUR

Rabbit PSOAS MUSCLE YG FRESH 1 EA

41217-2CC Pel-Freez 1 Each 234.6 EUR

Rabbit Creatine Kinase, Muscle (CKM) ELISA Kit

20-abx155049 Abbexa
  • 8684.40 EUR
  • 4626.00 EUR
  • 1074.00 EUR
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rabbit Glycogen Phosphorylase, Muscle (PYGM) ELISA Kit

abx362756-96tests Abbexa 96 tests 990 EUR

Rabbit Pyruvate Kinase, Muscle (PKM) ELISA Kit

abx363287-96tests Abbexa 96 tests 990 EUR

Rabbit Smooth Muscle Myosin (SMM) ELISA Kit

abx363652-96tests Abbexa 96 tests 990 EUR

Rabbit Creatine Kinase, Muscle (CKM) CLIA Kit

20-abx491038 Abbexa
  • 10282.80 EUR
  • 5472.00 EUR
  • 1262.40 EUR
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rabbit Creatine Kinase, Muscle (CKM) ELISA Kit

DLR-CKM-Rb-48T DL Develop 48T 609.6 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Creatine Kinase, Muscle (CKM) in samples from serum, plasma or other biological fluids.

Rabbit Creatine Kinase, Muscle (CKM) ELISA Kit

DLR-CKM-Rb-96T DL Develop 96T 793.2 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Creatine Kinase, Muscle (CKM) in samples from serum, plasma or other biological fluids.

Rabbit Anti Smooth Muscle Antibody ELISA kit

E04A0436-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Anti Smooth Muscle Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Anti Smooth Muscle Antibody ELISA kit

E04A0436-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Anti Smooth Muscle Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Anti Smooth Muscle Antibody ELISA kit

E04A0436-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Anti Smooth Muscle Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Alpha Smooth Muscle Actin ELISA kit

E04S0004-192T BlueGene 192 tests 1524 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Alpha Smooth Muscle Actin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
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Il processo di degradazione ha interessato principalmente la porzione 4,4-dimetil-3,4-diidro-2H-tiopirano. I frammenti più suscettibili all’ossidazione erano i gruppi metilici e l’atomo di zolfo. Inoltre, in presenza di sulisobenzone, sotto irradiazione UV, il tazarotene è stato sottoposto ad un processo di degradazione, che ha portato a due prodotti di fotodecomposizione. Studi in silico eseguiti da OSIRIS Property Explorer hanno dimostrato che cinque dei prodotti di degradazione potrebbero essere dannosi in termini di effetti riproduttivi, che sono associati a 3,4-diidro-6-metil-2H-1-benzotiopirano 1,1-diossido, mentre uno di loro ha dimostrato una potenziale attività irritante. Le proprietà citotossiche dei prodotti di degradazione del tazarotene sono state valutate mediante dosaggio MTT su un pannello di cellule cancerose umane aderenti. L’inibizione della crescita dipendente dal tempo e dalla concentrazione è stata evidenziata nelle linee cellulari di cancro dell’ovaio (A2780) e della mammella (MDA-MB-231). La potenziale implicazione dei risultati della presente ricerca richiede ulteriori studi riguardanti principalmente la fotostabilità del tazarotene nelle formulazioni topiche.

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