Una preoccupazione per il crescente uso di farmaci da prescrizione durante la gravidanza è il rischio teratogeno. Questo rischio non è determinato per la maggior parte dei farmaci approvati negli Stati Uniti (USA) dal 2000 al 2010. L’acne e la psoriasi sono malattie croniche che si verificano tipicamente durante l’età fertile e poiché i retinoidi topici sono raccomandati sia per il trattamento dell’acne che per la psoriasi, è è possibile che le donne siano esposte a un retinoide topico durante la gravidanza. Gli studi di farmacocinetica mostrano un’esposizione sistemica relativamente bassa ai retinoidi topici, ma i livelli di esposizione che potrebbero portare a teratogenicità nell’uomo non sono noti. Il tazarotene, un retinoide topico, è stato approvato dalla Food and Drug Administration (FDA) statunitense sia per l’acne che per la psoriasi utilizzando i dati di farmacocinetica degli studi sulla psoriasi, che hanno stimato i dati basati sull’uso del tazarotene fino al 20% della superficie corporea.
Pertanto, sia in base all’etichettatura della gravidanza precedente che in quella attuale della FDA, il tazarotene non è raccomandato per l’uso durante la gravidanza. L’obiettivo di questa revisione della letteratura era fornire un contesto storico per la regola di etichettatura della gravidanza per il tazarotene rispetto ad altri retinoidi approvati e raccogliere i dati disponibili sugli esiti della gravidanza correlati a tazarotene e retinoidi. Sebbene vi siano segnalazioni di casi di esposizione topica alla tretinoina e all’adapalene in utero, non è chiaro se entrambe abbiano influenzato lo sviluppo fetale. In termini di tazarotene topico, ci sono attualmente dati limitati sugli esiti della gravidanza dopo l’esposizione in utero. Sono necessari ulteriori case report e studi sui risultati per esplorare ulteriormente la sicurezza del tazarotene topico in gravidanza.
La chemerina è indotta nella steatosi epatica non alcolica e nel carcinoma epatocellulare correlato all’epatite B
Chemerin è protettivo nei modelli sperimentali di carcinoma epatocellulare (HCC). Degno di nota, l’mRNA e le proteine della chemerina sono stati ridotti nei tessuti HCC di pazienti asiatici con eziologia per lo più della malattia da epatite B. L’attuale studio ha tuttavia dimostrato che la proteina chemerina è stata indotta nei tessuti tumorali di pazienti europei con HCC con steatosi epatica non alcolica (NAFLD) e pazienti con eziologia della malattia poco chiara. Una regolazione simile è stata osservata nel virus dell’epatite B (HBV), ma non nel virus dell’epatite C (HCV), HCC correlato. L’apparente discrepanza tra la regolazione della chemerina nell’HBV-HCC ottenuta dal nostro studio e rapporti recenti ci ha portato ad utilizzare gli anticorpi chemerina applicati nei saggi precedenti. Questi anticorpi non sono stati in grado di rilevare ugualmente diverse isoforme di chemerina, che erano sovraespresse nelle cellule HepG2.
Tuttavia, l’uso di tutti gli anticorpi ha confermato la presenza di una maggiore proteina chemerina nell’HCC. La proteina chemerina era bassa nelle cellule Huh7 e PLC / PRF / 5, mentre le cellule HepG2 e Hep3B avevano una proteina chemerina simile agli epatociti umani primari. Inoltre, gli effetti antitumorali dei retinoidi nelle linee cellulari degli epatociti non includevano la sovraregolazione della chemerina, che è stata inizialmente scoperta come proteina indotta dal tazarotene nella pelle. Infine, i livelli di proteine del recettore delle chemerine, il recettore 1 simile alle chemochine (CMKLR1), sono diminuiti nei tessuti non virali e tendevano ad essere inferiori nei tessuti HBV-HCC, suggerendo una ridotta attività delle chemerine nei tumori. Per riassumere, il nostro lavoro ha mostrato una regolazione opposta di chemerina e CMKLR1 in NAFLD e HCC associato a HBV. Nell’HCV-HCC né la chemerina né il suo recettore sono stati modificati nei tessuti tumorali. I risultati attuali non supportano un ruolo critico dei livelli di proteine totali delle chemerine nell’HCC di eziologia non virale e virale. Di conseguenza, la proteina chemerina localizzata nel tumore non era associata alla classificazione delle metastasi del nodo tumorale.
Test di fotostabilità di un retinoide-tazarotene di terza generazione in presenza di assorbitori UV
L’esposizione di un farmaco all’irradiazione UV potrebbe influire sulle sue proprietà fisico-chimiche. Pertanto, il test di fotostabilità è essenziale per i farmaci somministrati per via topica. Il tazarotene, un retinoide di terza generazione selettivo per i recettori, è comunemente usato per curare l’acne vulgaris e la psoriasi. Nel presente studio è stata eseguita un’analisi approfondita della fotostabilità del tazarotene in soluzione etanolica in presenza di ossido di zinco e / o biossido di titanio e filtri UV di tipo benzofenone. Undici presunti prodotti sono stati derivati dalla degradazione fotocatalitica del tazarotene utilizzando la cromatografia liquida ad alte prestazioni-spettrometria di massa tandem e sono stati proposti percorsi di trasformazione.
Soft Tissue Tissue Slide (Skeletal Muscle-Benign) |
|||
| 12-343-10um | ProSci | 10 um | 241.8 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-Benign) |
|||
| 12-343-4um | ProSci | 4 um | 216.6 EUR |
Mouse Skeletal Muscle Tissue Lysate |
|||
| LYSATE0021 | BosterBio | 200ug | 180 EUR |
|
Description: This cell lysate is prepared from mouse skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C. |
|||
Soft Tissue Tissue Slide (Skeletal Muscle-malignant) |
|||
| 12-345-10um | ProSci | 10 um | 241.8 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-malignant) |
|||
| 12-345-4um | ProSci | 4 um | 216.6 EUR |
Rat Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells |
|||
| 9-80281 | CHI Scientific | 1 x 100 ml | Ask for price |
Smooth muscle and striated muscle disease spectrum tissue array |
|||
| SO8011 | TissueArray | each | 414 EUR |
|
Description: Smooth muscle and striated muscle disease spectrum tissue array, including TNM and clinical stage, 80 cases /80 cores |
|||
Human Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells |
|||
| 9-80092 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells |
|||
| 9-80189 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells |
|||
| 9-80280 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells |
|||
| 9-80091 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells |
|||
| 9-80188 | CHI Scientific | 1 x 100 ml | Ask for price |
cDNA - Rat Normal Tissue: Skeletal Muscle |
|||
| C1434171 | Biochain | 40 reactions | 385 EUR |
cDNA - Dog Normal Tissue: Skeletal Muscle |
|||
| C1734171 | Biochain | 40 reactions | 385 EUR |
cDNA - Human Tumor Tissue: Skeletal Muscle |
|||
| C1235171-10 | Biochain | 10 reactions | 274 EUR |
Rat Skeletal Muscle Whole tissue lysate |
|||
| RAL-1467 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Rhabdomyosarcoma with striated muscle tissue array |
|||
| SO2082b | TissueArray | each | 546 EUR |
|
Description: Rhabdomyosarcoma with striated muscle tissue array, including TNM and clinical stage, 104 cases/208 cores, replacing SO2082a |
|||
Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array |
|||
| SO2081 | TissueArray | each | 474 EUR |
|
Description: Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array, 104 cases/208 cores |
|||
cDNA - Mouse Normal Tissue: Skeletal Muscle |
|||
| C1334171 | Biochain | 40 reactions | 385 EUR |
Mouse Skeletal Muscle Whole tissue lysate |
|||
| MAL-1407 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Skeletal Muscle |
|||
| T1236171Dia | Biochain | 5 slides | 475 EUR |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Skeletal Muscle |
|||
| T2236171Dia | Biochain | 5 slides | 238 EUR |
Total RNA - Rat Normal Tissue: Skeletal Muscle |
|||
| R1434171-50 | Biochain | 50 ug | 130 EUR |
Rat Muscle OptiTDS1: Tissue Dissociation System |
|||
| 4-28280 | CHI Scientific | 1 Kit | Ask for price |
Rat Muscle OptiTDS2: Tissue Dissociation System |
|||
| 4-28281 | CHI Scientific | 1 Kit | Ask for price |
Genomic DNA - Rat Normal Tissue: Skeletal Muscle |
|||
| D1434171 | Biochain | 100 ug | 286 EUR |
Total RNA - Mouse Normal Tissue: Skeletal Muscle |
|||
| R1334171-50 | Biochain | 50 ug | 130 EUR |
Human Muscle OptiTDS1: Tissue Dissociation System |
|||
| 4-28091 | CHI Scientific | 1 Kit | Ask for price |
Human Muscle OptiTDS2: Tissue Dissociation System |
|||
| 4-28092 | CHI Scientific | 1 Kit | Ask for price |
Mouse Muscle OptiTDS1: Tissue Dissociation System |
|||
| 4-28188 | CHI Scientific | 1 Kit | Ask for price |
Mouse Muscle OptiTDS2: Tissue Dissociation System |
|||
| 4-28189 | CHI Scientific | 1 Kit | Ask for price |
cDNA - Human Adult Normal Tissue: Skeletal Muscle |
|||
| C1234171 | Biochain | 40 reactions | 385 EUR |
Genomic DNA - Mouse Normal Tissue: Skeletal Muscle |
|||
| D1334171 | Biochain | 100 ug | 286 EUR |
cDNA - Monkey (Rhesus) Normal Tissue: Skeletal Muscle |
|||
| C1534171 | Biochain | 40 reactions | 385 EUR |
Total Protein - Human Tumor Tissue: Skeletal Muscle |
|||
| P1235171 | Biochain | 1 mg | 310 EUR |
Total Protein - Mouse Normal Tissue: Skeletal Muscle |
|||
| P1334171 | Biochain | 1 mg | 188 EUR |
cDNA - Human Diabetic Diseased Tissue: Skeletal Muscle |
|||
| C1236171Dia | Biochain | 40 reactions | 729 EUR |
cDNA - Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle |
|||
| C1534171-Cy | Biochain | 40 reactions | 385 EUR |
Total RNA - Human Adult Normal Tissue: Skeletal Muscle |
|||
| R1234171-50 | Biochain | 50 ug | 170 EUR |
Total RNA - Human Adult Normal Tissue: Muscle: Diaphragm |
|||
| R1234169-10 | Biochain | 10 ug | 183 EUR |
Total RNA - Monkey (Rhesus) Normal Tissue: Skeletal Muscle |
|||
| R1534171-50 | Biochain | 50 ug | 191 EUR |
Monkey (Cyno.) Normal Skeletal Muscle Whole tissue lysate |
|||
| MCL-1197 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Human Adult Skeletal Muscle (Normal) Whole tissue lysate |
|||
| HAL-1375 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Total Protein - Human Adult Normal Tissue: Skeletal Muscle |
|||
| P1234171 | Biochain | 1 mg | 188 EUR |
Monkey (Rhesus) Normal Skeletal Muscle Whole tissue lysate |
|||
| MRL-1247 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Frozen Tissue Section - Human Adult Normal: Skeletal Muscle |
|||
| T1234171 | Biochain | 5 slides | 343 EUR |
Total RNA - Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle |
|||
| R1534171-Cy | Biochain | 50 ug | 191 EUR |
Total RNA - Human Adult Normal Tissue: Heart: Papilla Muscle |
|||
| R1234132-10 | Biochain | 10 ug | 183 EUR |
Membrane Protein - Human Adult Normal Tissue: Skeletal Muscle |
|||
| P3234171 | Biochain | 0.1 mg | 270 EUR |
Paraffin Tissue Section - Human Adult Normal: Skeletal Muscle |
|||
| T2234171 | Biochain | 5 slides | 185 EUR |
Total Protein - Human Diabetic Diseased Tissue: Skeletal Muscle |
|||
| P1236171Dia | Biochain | 1 mg | 471 EUR |
Total Protein - Human Adult Normal Tissue: Heart: Papilla Muscle |
|||
| P1234132 | Biochain | 1 mg | 513 EUR |
Actin, Rabbit Muscle |
|||
| P1246-1000 | Biovision | each | 274.8 EUR |
Actin, Rabbit Muscle |
|||
| P1246-500 | Biovision | each | 196.8 EUR |
Human Soft Tissue Slide (Skeletal Muscle Normal) (5 slides/pk) |
|||
| HTS-12341 | Alpha Diagnostics | 1 pk | 343.2 EUR |
Human Soft Tissue Slide (Skeletal Muscle Benign) (5 slides/pk) |
|||
| HTS-12343 | Alpha Diagnostics | 1 pk | 343.2 EUR |
Paraffin Tissue Section - Human Adult Normal: Heart: Papilla Muscle |
|||
| T2234132 | Biochain | 5 slides | 185 EUR |
Human Soft Tissue Slide (Skeletal Muscle Malignant) (5 slides/pk) |
|||
| HTS-12345 | Alpha Diagnostics | 1 pk | 343.2 EUR |
Total RNA - Human Adult Normal Tissue 5 Donor Pool: Skeletal Muscle |
|||
| R1234171-P | Biochain | 50 ug | 370 EUR |
Rat Bladder Tissue Preparation Buffer 3: Normal Smooth Muscle Cells |
|||
| 9-80215 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells |
|||
| 9-80288 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells |
|||
| 9-80100 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells |
|||
| 9-80198 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Heart Tissue Preparation Buffer 1: Normal Aortic Smooth Muscle Cells |
|||
| 9-80253 | CHI Scientific | 1 x 100 ml | Ask for price |
Aldolase (Rabbit Muscle) Antibody |
|||
| abx022821-50mg | Abbexa | 50 mg | 1262.4 EUR |
Human Heart Tissue Preparation Buffer 1: Normal Aortic Smooth Muscle Cells |
|||
| 9-80066 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Heart Tissue Preparation Buffer 1: Normal Aortic Smooth Muscle Cells |
|||
| 9-80159 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Cervix Tissue Preparation Buffer 3: Normal Cervical Smooth Muscle Cells |
|||
| 9-80233 | CHI Scientific | 1 x 100 ml | Ask for price |
Genomic DNA - Human Adult Normal Tissue: Skeletal Muscle, from a single donor |
|||
| D1234171 | Biochain | 100 ug | 286 EUR |
Human Bladder Tissue Preparation Buffer 3: Normal Bladder Smooth Muscle Cells |
|||
| 9-80009 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Cervix Tissue Preparation Buffer 3: Normal Cervical Smooth Muscle Cells |
|||
| 9-80046 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Cervix Tissue Preparation Buffer 3: Normal Cervical Smooth Muscle Cells |
|||
| 9-80139 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Colon Tissue Preparation Buffer 2: Normal Colorectal Smooth Muscle Cells |
|||
| 9-80237 | CHI Scientific | 1 x 100 ml | Ask for price |
Rabbit MUSCLE ACETONE POWDER 10g |
|||
| 41995-2 | Pel-Freez | 10g | 328.56 EUR |
Purified (>95%) muscle Actin Protein from muscle (rabbit/bovine) |
|||
| ACTB15-N-1 | Alpha Diagnostics | 1 mg | 489.6 EUR |
Rat Esophagus Tissue Preparation Buffer 2: Normal Esophageal Smooth Muscle Cells |
|||
| 9-80244 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Intestine Tissue Preparation Buffer 2: Normal Intestinal Smooth Muscle Cells |
|||
| 9-80260 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Lung Tissue Preparation Buffer 6: Normal Pulmonary Vein Smooth Muscle Cells |
|||
| 9-80276 | CHI Scientific | 1 x 100 ml | Ask for price |
Genomic DNA - Human Diabetic Diseased Tissue: Skeletal Muscle, from a single donor |
|||
| D1236171Dia | Biochain | 50 ug | 489 EUR |
Actin, pyrene labeled, Rabbit Muscle |
|||
| M1319-1000 | Biovision | each | 222 EUR |
Actin, pyrene labeled, Rabbit Muscle |
|||
| M1319-500 | Biovision | each | 183.6 EUR |
Human Esophagus Tissue Preparation Buffer 2: Normal Esophageal Smooth Muscle Cells |
|||
| 9-80056 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Intestine Tissue Preparation Buffer 2: Normal Intestinal Smooth Muscle Cells |
|||
| 9-80072 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Esophagus Tissue Preparation Buffer 2: Normal Esophageal Smooth Muscle Cells |
|||
| 9-80150 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Intestine Tissue Preparation Buffer 4: Normal Intestinal Smooth Muscle Cells |
|||
| 9-80168 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Lung Tissue Preparation Buffer 6: Normal Pulmonary Vein Smooth Muscle Cells |
|||
| 9-80086 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Lung Tissue Preparation Buffer 7: Normal Pulmonary Vein Smooth Muscle Cells |
|||
| 9-80184 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Lung Tissue Preparation Buffer 4: Normal Pulmonary Artery Smooth Muscle Cells |
|||
| 9-80274 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Lung Tissue Preparation Buffer 4: Normal Pulmonary Artery Smooth Muscle Cells |
|||
| 9-80084 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Lung Tissue Preparation Buffer 5: Normal Pulmonary Artery Smooth Muscle Cells |
|||
| 9-80182 | CHI Scientific | 1 x 100 ml | Ask for price |
Rabbit MUSCLE ACETONE POWDER (1-g) |
|||
| 41995-1 | Pel-Freez | 1g | 144.55 EUR |
Rat Umbilical Cord Tissue Preparation Buffer: Normal Umbilical Vein Smooth Muscle Cells |
|||
| 9-80294 | CHI Scientific | 1 x 100 ml | Ask for price |
Creatine Kinase (CK/CPK), Rabbit Muscle |
|||
| P1301-1 | Biovision | each | 164.4 EUR |
Creatine Kinase (CK/CPK), Rabbit Muscle |
|||
| P1301-25 | Biovision | each | 679.2 EUR |
alpha Actin (Skeletal Muscle) (Rabbit) |
|||
| 30R-3107 | Fitzgerald | 1 mg | 308.4 EUR |
|
Description: Purified native alpha Actin (Skeletal Muscle) (Rabbit) |
|||
Mouse Umbilical Cord Tissue Preparation Buffer: Normal Umbilical Vein Smooth Muscle Cells |
|||
| 9-80205 | CHI Scientific | 1 x 100 ml | Ask for price |
Rabbit Skeletal Muscle Troponin-C |
|||
| 7-06205 | CHI Scientific | 1mg | Ask for price |
Rabbit Skeletal Muscle Troponin-C |
|||
| 7-06206 | CHI Scientific | 5mg | Ask for price |
Rabbit Skeletal Muscle Troponin-C |
|||
| 7-06207 | CHI Scientific | 10mg | Ask for price |
Tissue Factor Rabbit mAb |
|||
| A4395-100ul | Abclonal | 100 ul | 492 EUR |
Tissue Factor Rabbit mAb |
|||
| A4395-200ul | Abclonal | 200 ul | 685.2 EUR |
Tissue Factor Rabbit mAb |
|||
| A4395-20ul | Abclonal | 20 ul | 265.2 EUR |
Tissue Factor Rabbit mAb |
|||
| A4395-50ul | Abclonal | 50 ul | 344.4 EUR |
Rat Airway Tissue Preparation Buffer 2: Normal Bronchial and Tracheal Smooth Muscle Cells |
|||
| 9-80209 | CHI Scientific | 1 x 100 ml | Ask for price |
Rabbit Cofilin 2, Muscle ELISA kit |
|||
| E04C0470-192T | BlueGene | 192 tests | 1524 EUR |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Rabbit Cofilin 2, Muscle ELISA kit |
|||
| E04C0470-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Rabbit Cofilin 2, Muscle ELISA kit |
|||
| E04C0470-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Rabbit Liver Tissue Lysate |
|||
| 30R-AL003 | Fitzgerald | 150 ug | 302.4 EUR |
|
Description: Fresh tissue lysate prepared from rabbit liver |
|||
Human Airway Tissue Preparation Buffer 3: Normal Bronchial and Tracheal Smooth Muscle Cells |
|||
| 9-80003 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Umbilical Cord Tissue Preparation Buffer 5: Normal Umbilical Vein Smooth Muscle Cells |
|||
| 9-80110 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Airway Tissue Preparation Buffer 2: Normal Bronchial and Tracheal Smooth Muscle Cells |
|||
| 9-80116 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Brain Tissue Preparation Buffer 11: Normal Cerebral Artery Vascular Smooth Muscle Cells |
|||
| 9-80220 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Brain Tissue Preparation Buffer 5: Normal Cerebral Venous Vascular Smooth Muscle Cells |
|||
| 9-80223 | CHI Scientific | 1 x 100 ml | Ask for price |
alpha smooth muscle actin Rabbit pAb |
|||
| A0957-100ul | Abclonal | 100 ul | 460.8 EUR |
alpha smooth muscle actin Rabbit pAb |
|||
| A0957-200ul | Abclonal | 200 ul | Ask for price |
alpha smooth muscle actin Rabbit pAb |
|||
| A0957-20ul | Abclonal | 20 ul | Ask for price |
alpha smooth muscle actin Rabbit pAb |
|||
| A0957-50ul | Abclonal | 50 ul | 318 EUR |
alpha smooth muscle actin Rabbit pAb |
|||
| A1011-100ul | Abclonal | 100 ul | 369.6 EUR |
alpha smooth muscle actin Rabbit pAb |
|||
| A1011-200ul | Abclonal | 200 ul | 550.8 EUR |
alpha smooth muscle actin Rabbit pAb |
|||
| A1011-20ul | Abclonal | 20 ul | 219.6 EUR |
alpha smooth muscle actin Rabbit pAb |
|||
| A1011-50ul | Abclonal | 50 ul | 267.6 EUR |
alpha smooth muscle Actin Rabbit mAb |
|||
| A17910 | Abclonal | 20 μL | 18 EUR |
alpha smooth muscle Actin Rabbit mAb |
|||
| A17910-100ul | Abclonal | 100 ul | 492 EUR |
alpha smooth muscle Actin Rabbit mAb |
|||
| A17910-200ul | Abclonal | 200 ul | 685.2 EUR |
alpha smooth muscle Actin Rabbit mAb |
|||
| A17910-20ul | Abclonal | 20 ul | 265.2 EUR |
alpha smooth muscle Actin Rabbit mAb |
|||
| A17910-50ul | Abclonal | 50 ul | 344.4 EUR |
alpha smooth muscle actin Rabbit pAb |
|||
| A7248-100ul | Abclonal | 100 ul | 369.6 EUR |
alpha smooth muscle actin Rabbit pAb |
|||
| A7248-200ul | Abclonal | 200 ul | 550.8 EUR |
alpha smooth muscle actin Rabbit pAb |
|||
| A7248-20ul | Abclonal | 20 ul | 219.6 EUR |
alpha smooth muscle actin Rabbit pAb |
|||
| A7248-50ul | Abclonal | 50 ul | 267.6 EUR |
Rabbit Eye muscle antibody ELISA kit |
|||
| E04E0148-192T | BlueGene | 192 tests | 1524 EUR |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Rabbit Eye muscle antibody ELISA kit |
|||
| E04E0148-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Rabbit Eye muscle antibody ELISA kit |
|||
| E04E0148-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Rabbit PSOAS MUSCLE YG FRESH 1 EA |
|||
| 41217-2CC | Pel-Freez | 1 Each | 234.6 EUR |
Human Brain Tissue Preparation Buffer 3: Normal Cerebral Artery Vascular Smooth Muscle Cells |
|||
| 9-80015 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Brain Tissue Preparation Buffer 6: Normal Cerebral Venous Vascular Smooth Muscle Cells |
|||
| 9-80018 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Umbilical Cord Tissue Preparation Buffer 2: Normal Umbilical Artery Smooth Muscle Cells |
|||
| 9-80107 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Brain Tissue Preparation Buffer 3: Normal Cerebral Artery Vascular Smooth Muscle Cells |
|||
| 9-80126 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Brain Tissue Preparation Buffer 6: Normal Cerebral Venous Vascular Smooth Muscle Cells |
|||
| 9-80129 | CHI Scientific | 1 x 100 ml | Ask for price |
Rabbit PSOAS MUSCLE YG FROZEN 1 EA |
|||
| 41217-1 | Pel-Freez | 1 Each | 216.34 EUR |
Rabbit Creatine Kinase, Muscle ELISA kit |
|||
| E04C0400-192T | BlueGene | 192 tests | 1524 EUR |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Rabbit Creatine Kinase, Muscle ELISA kit |
|||
| E04C0400-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Rabbit Creatine Kinase, Muscle ELISA kit |
|||
| E04C0400-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I |
|||
| T6834700-G01-1 | Biochain | 1 slide | 239 EUR |
Il processo di degradazione ha interessato principalmente la porzione 4,4-dimetil-3,4-diidro-2H-tiopirano. I frammenti più suscettibili all’ossidazione erano i gruppi metilici e l’atomo di zolfo. Inoltre, in presenza di sulisobenzone, sotto irradiazione UV, il tazarotene è stato sottoposto ad un processo di degradazione, che ha portato a due prodotti di fotodecomposizione. Studi in silico eseguiti da OSIRIS Property Explorer hanno dimostrato che cinque dei prodotti di degradazione potrebbero essere dannosi in termini di effetti riproduttivi, che sono associati a 3,4-diidro-6-metil-2H-1-benzotiopirano 1,1-diossido, mentre uno di loro ha dimostrato una potenziale attività irritante. Le proprietà citotossiche dei prodotti di degradazione del tazarotene sono state valutate mediante dosaggio MTT su un pannello di cellule cancerose umane aderenti. L’inibizione della crescita dipendente dal tempo e dalla concentrazione è stata evidenziata nelle linee cellulari di cancro dell’ovaio (A2780) e della mammella (MDA-MB-231). La potenziale implicazione dei risultati della presente ricerca richiede ulteriori studi riguardanti principalmente la fotostabilità del tazarotene nelle formulazioni topiche.
