Uso di tazarotene topico per il trattamento dell’acne vulgaris in gravidanza: una revisione della letteratura

Una preoccupazione per il crescente uso di farmaci da prescrizione durante la gravidanza è il rischio teratogeno. Questo rischio non è determinato per la maggior parte dei farmaci approvati negli Stati Uniti (USA) dal 2000 al 2010. L’acne e la psoriasi sono malattie croniche che si verificano tipicamente durante l’età fertile e poiché i retinoidi topici sono raccomandati sia per il trattamento dell’acne che per la psoriasi, è è possibile che le donne siano esposte a un retinoide topico durante la gravidanza. Gli studi di farmacocinetica mostrano un’esposizione sistemica relativamente bassa ai retinoidi topici, ma i livelli di esposizione che potrebbero portare a teratogenicità nell’uomo non sono noti. Il tazarotene, un retinoide topico, è stato approvato dalla Food and Drug Administration (FDA) statunitense sia per l’acne che per la psoriasi utilizzando i dati di farmacocinetica degli studi sulla psoriasi, che hanno stimato i dati basati sull’uso del tazarotene fino al 20% della superficie corporea.

Pertanto, sia in base all’etichettatura della gravidanza precedente che in quella attuale della FDA, il tazarotene non è raccomandato per l’uso durante la gravidanza. L’obiettivo di questa revisione della letteratura era fornire un contesto storico per la regola di etichettatura della gravidanza per il tazarotene rispetto ad altri retinoidi approvati e raccogliere i dati disponibili sugli esiti della gravidanza correlati a tazarotene e retinoidi. Sebbene vi siano segnalazioni di casi di esposizione topica alla tretinoina e all’adapalene in utero, non è chiaro se entrambe abbiano influenzato lo sviluppo fetale. In termini di tazarotene topico, ci sono attualmente dati limitati sugli esiti della gravidanza dopo l’esposizione in utero. Sono necessari ulteriori case report e studi sui risultati per esplorare ulteriormente la sicurezza del tazarotene topico in gravidanza.

La chemerina è indotta nella steatosi epatica non alcolica e nel carcinoma epatocellulare correlato all’epatite B

Chemerin è protettivo nei modelli sperimentali di carcinoma epatocellulare (HCC). Degno di nota, l’mRNA e le proteine ​​della chemerina sono stati ridotti nei tessuti HCC di pazienti asiatici con eziologia per lo più della malattia da epatite B. L’attuale studio ha tuttavia dimostrato che la proteina chemerina è stata indotta nei tessuti tumorali di pazienti europei con HCC con steatosi epatica non alcolica (NAFLD) e pazienti con eziologia della malattia poco chiara. Una regolazione simile è stata osservata nel virus dell’epatite B (HBV), ma non nel virus dell’epatite C (HCV), HCC correlato. L’apparente discrepanza tra la regolazione della chemerina nell’HBV-HCC ottenuta dal nostro studio e rapporti recenti ci ha portato ad utilizzare gli anticorpi chemerina applicati nei saggi precedenti. Questi anticorpi non sono stati in grado di rilevare ugualmente diverse isoforme di chemerina, che erano sovraespresse nelle cellule HepG2.

Tuttavia, l’uso di tutti gli anticorpi ha confermato la presenza di una maggiore proteina chemerina nell’HCC. La proteina chemerina era bassa nelle cellule Huh7 e PLC / PRF / 5, mentre le cellule HepG2 e Hep3B avevano una proteina chemerina simile agli epatociti umani primari. Inoltre, gli effetti antitumorali dei retinoidi nelle linee cellulari degli epatociti non includevano la sovraregolazione della chemerina, che è stata inizialmente scoperta come proteina indotta dal tazarotene nella pelle. Infine, i livelli di proteine ​​del recettore delle chemerine, il recettore 1 simile alle chemochine (CMKLR1), sono diminuiti nei tessuti non virali e tendevano ad essere inferiori nei tessuti HBV-HCC, suggerendo una ridotta attività delle chemerine nei tumori. Per riassumere, il nostro lavoro ha mostrato una regolazione opposta di chemerina e CMKLR1 in NAFLD e HCC associato a HBV. Nell’HCV-HCC né la chemerina né il suo recettore sono stati modificati nei tessuti tumorali. I risultati attuali non supportano un ruolo critico dei livelli di proteine ​​totali delle chemerine nell’HCC di eziologia non virale e virale. Di conseguenza, la proteina chemerina localizzata nel tumore non era associata alla classificazione delle metastasi del nodo tumorale.

Test di fotostabilità di un retinoide-tazarotene di terza generazione in presenza di assorbitori UV

L’esposizione di un farmaco all’irradiazione UV potrebbe influire sulle sue proprietà fisico-chimiche. Pertanto, il test di fotostabilità è essenziale per i farmaci somministrati per via topica. Il tazarotene, un retinoide di terza generazione selettivo per i recettori, è comunemente usato per curare l’acne vulgaris e la psoriasi. Nel presente studio è stata eseguita un’analisi approfondita della fotostabilità del tazarotene in soluzione etanolica in presenza di ossido di zinco e / o biossido di titanio e filtri UV di tipo benzofenone. Undici presunti prodotti sono stati derivati ​​dalla degradazione fotocatalitica del tazarotene utilizzando la cromatografia liquida ad alte prestazioni-spettrometria di massa tandem e sono stati proposti percorsi di trasformazione.

Soft Tissue Tissue Slide (Skeletal Muscle-Benign)
12-343-4um	ProSci	4 um	216.6 EUR
Soft Tissue Tissue Slide (Skeletal Muscle-malignant)
12-345-10um	ProSci	10 um	241.8 EUR
Soft Tissue Tissue Slide (Skeletal Muscle-malignant)
12-345-4um	ProSci	4 um	216.6 EUR
Rat Skeletal Muscle Tissue Lysate
LYSATE0010	BosterBio	200ug	180 EUR
Description: This cell lysate is prepared from rat skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C.
Mouse Skeletal Muscle Tissue Lysate
LYSATE0021	BosterBio	200ug	180 EUR
Description: This cell lysate is prepared from mouse skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C.
Paraffin Tissue Section - Human Diabetic Tissue: Skeletal Muscle
T2236171Dia	Biochain	5 slides	308.4 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Frozen Tissue Section - Human Diabetic Tissue: Skeletal Muscle
T1236171Dia	Biochain	5 slides	558 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Smooth muscle and striated muscle disease spectrum tissue array
SO8011	TissueArray	each	414 EUR
Description: Smooth muscle and striated muscle disease spectrum tissue array, including TNM and clinical stage, 80 cases /80 cores
Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array
SO2081	TissueArray	each	474 EUR
Description: Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array, 104 cases/208 cores
Actin, Rabbit Muscle
P1246-1000	Biovision	each	274.8 EUR
Actin, Rabbit Muscle
P1246-500	Biovision	each	196.8 EUR
Human Muscle OptiTDS1: Tissue Dissociation System
4-28091	CHI Scientific	1 Kit	Ask for price
Human Muscle OptiTDS2: Tissue Dissociation System
4-28092	CHI Scientific	1 Kit	Ask for price
Mouse Muscle OptiTDS1: Tissue Dissociation System
4-28188	CHI Scientific	1 Kit	Ask for price
Mouse Muscle OptiTDS2: Tissue Dissociation System
4-28189	CHI Scientific	1 Kit	Ask for price
Rat Muscle OptiTDS1: Tissue Dissociation System
4-28280	CHI Scientific	1 Kit	Ask for price
Rat Muscle OptiTDS2: Tissue Dissociation System
4-28281	CHI Scientific	1 Kit	Ask for price
Mouse Skeletal Muscle Whole tissue lysate
MAL-1407	Alpha Diagnostics	1 mg	628.8 EUR
Rat Skeletal Muscle Whole tissue lysate
RAL-1467	Alpha Diagnostics	1 mg	628.8 EUR
Rhabdomyosarcoma with striated muscle tissue array
SO2082b	TissueArray	each	546 EUR
Description: Rhabdomyosarcoma with striated muscle tissue array, including TNM and clinical stage, 104 cases/208 cores, replacing SO2082a
Human Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells
9-80091	CHI Scientific	1 x 100 ml	Ask for price
Human Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells
9-80092	CHI Scientific	1 x 100 ml	Ask for price
Mouse Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells
9-80188	CHI Scientific	1 x 100 ml	Ask for price
Mouse Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells
9-80189	CHI Scientific	1 x 100 ml	Ask for price
Rat Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells
9-80280	CHI Scientific	1 x 100 ml	Ask for price
Rat Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells
9-80281	CHI Scientific	1 x 100 ml	Ask for price
cDNA from Human Tumor Tissue: Skeletal Muscle
C1235171-10	Biochain	10 reactions	338.4 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Human Diabetic Tissue: Skeletal Muscle
C1236171Dia	Biochain	40 reactions	801.6 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Mouse Normal Tissue: Skeletal Muscle
C1334171	Biochain	40 reactions	451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Rat Normal Tissue: Skeletal Muscle
C1434171	Biochain	40 reactions	451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Dog Normal Tissue: Skeletal Muscle
C1734171	Biochain	40 reactions	451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Aldolase (Rabbit Muscle) Antibody
abx022821-50mg	Abbexa	50 mg	1262.4 EUR
Genomic DNA from Mouse Normal Tissue: Skeletal Muscle
D1334171	Biochain	100 ug	338.4 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Genomic DNA from Rat Normal Tissue: Skeletal Muscle
D1434171	Biochain	100 ug	338.4 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Human Adult Normal Tissue: Skeletal Muscle
C1234171	Biochain	40 reactions	451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Monkey (Rhesus) Normal Tissue: Skeletal Muscle
C1534171	Biochain	40 reactions	451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle
C1534171-Cy	Biochain	40 reactions	451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Monkey (Cyno.) Normal Skeletal Muscle Whole tissue lysate
MCL-1197	Alpha Diagnostics	1 mg	628.8 EUR
Monkey (Rhesus) Normal Skeletal Muscle Whole tissue lysate
MRL-1247	Alpha Diagnostics	1 mg	628.8 EUR
Total Protein from Human Tumor Tissue: Skeletal Muscle
P1235171	Biochain	1 mg	384 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Human Diabetic Tissue: Skeletal Muscle
P1236171Dia	Biochain	1 mg	553.2 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Mouse Normal Tissue: Skeletal Muscle
P1334171	Biochain	1 mg	256.8 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Human Adult Skeletal Muscle (Normal) Whole tissue lysate
HAL-1375	Alpha Diagnostics	1 mg	628.8 EUR
Paraffin Tissue Section - Human Adult Normal: Skeletal Muscle
T2234171	Biochain	5 slides	253.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Frozen Tissue Section - Human Adult Normal: Skeletal Muscle
T1234171	Biochain	5 slides	418.8 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Total RNA from Mouse Normal Tissue: Skeletal Muscle
R1334171-50	Biochain	50 ug	182.4 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Total RNA from Rat Normal Tissue: Skeletal Muscle
R1434171-50	Biochain	50 ug	182.4 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Rabbit Liver Tissue Lysate
30R-AL003	Fitzgerald	150 ug	302.4 EUR
Description: Fresh tissue lysate prepared from rabbit liver
Tissue Factor Rabbit mAb
A4395-100ul	Abclonal	100 ul	492 EUR
Tissue Factor Rabbit mAb
A4395-200ul	Abclonal	200 ul	685.2 EUR
Tissue Factor Rabbit mAb
A4395-20ul	Abclonal	20 ul	265.2 EUR
Tissue Factor Rabbit mAb
A4395-50ul	Abclonal	50 ul	344.4 EUR
Purified (>95%) muscle Actin Protein from muscle (rabbit/bovine)
ACTB15-N-1	Alpha Diagnostics	1 mg	489.6 EUR
Rabbit Skeletal Muscle Troponin-C
7-06205	CHI Scientific	1mg	Ask for price
Rabbit Skeletal Muscle Troponin-C
7-06206	CHI Scientific	5mg	Ask for price
Rabbit Skeletal Muscle Troponin-C
7-06207	CHI Scientific	10mg	Ask for price
alpha Actin (Skeletal Muscle) (Rabbit)
30R-3107	Fitzgerald	1 mg	308.4 EUR
Description: Purified native alpha Actin (Skeletal Muscle) (Rabbit)
Rabbit MUSCLE ACETONE POWDER 10g
41995-2	Pel-Freez	10g	328.56 EUR
Actin, pyrene labeled, Rabbit Muscle
M1319-1000	Biovision	each	222 EUR
Actin, pyrene labeled, Rabbit Muscle
M1319-500	Biovision	each	183.6 EUR
Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I
T6834700-G01-1	Biochain	1 slide	309.6 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I
T6834700-G01-5	Biochain	5 slides	985.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I
T6834700-G02-1	Biochain	1 slide	309.6 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I
T6834700-G02-5	Biochain	5 slides	985.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Total Protein from Human Adult Normal Tissue: Skeletal Muscle
P1234171	Biochain	1 mg	256.8 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Membrane Protein from Human Adult Normal Tissue: Skeletal Muscle
P3234171	Biochain	0.1 mg	342 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Paraffin Tissue Section - Human Adult Normal: Heart: Papilla Muscle
T2234132	Biochain	5 slides	253.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Total RNA from Human Adult Normal Tissue: Muscle: Diaphragm
R1234169-10	Biochain	10 ug	232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Total RNA from Human Adult Normal Tissue: Skeletal Muscle
R1234171-50	Biochain	50 ug	213.6 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Total RNA from Monkey (Rhesus) Normal Tissue: Skeletal Muscle
R1534171-50	Biochain	50 ug	232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Total RNA from Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle
R1534171-Cy	Biochain	50 ug	232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Rabbit Tissue Factor (TF) Protein
20-abx069317	Abbexa	744.00 EUR 326.40 EUR 2230.80 EUR 878.40 EUR 543.60 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Rabbit Tissue Factor ELISA kit
E04T0037-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Factor ELISA kit
E04T0037-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Factor ELISA kit
E04T0037-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Transglutaminase ELISA kit
E04T0766-192T	BlueGene	192 tests	1524 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Tissue Transglutaminase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Transglutaminase ELISA kit
E04T0766-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Tissue Transglutaminase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Transglutaminase ELISA kit
E04T0766-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Tissue Transglutaminase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue factor ELISA Kit
ELA-E0524Rb	Lifescience Market	96 Tests	1113.6 EUR
alpha smooth muscle actin Rabbit pAb
A0957-100ul	Abclonal	100 ul	460.8 EUR
alpha smooth muscle actin Rabbit pAb
A0957-200ul	Abclonal	200 ul	Ask for price
alpha smooth muscle actin Rabbit pAb
A0957-20ul	Abclonal	20 ul	Ask for price
alpha smooth muscle actin Rabbit pAb
A0957-50ul	Abclonal	50 ul	318 EUR
alpha smooth muscle actin Rabbit pAb
A1011-100ul	Abclonal	100 ul	369.6 EUR
alpha smooth muscle actin Rabbit pAb
A1011-200ul	Abclonal	200 ul	550.8 EUR
alpha smooth muscle actin Rabbit pAb
A1011-20ul	Abclonal	20 ul	219.6 EUR
alpha smooth muscle actin Rabbit pAb
A1011-50ul	Abclonal	50 ul	267.6 EUR
Rabbit MUSCLE ACETONE POWDER (1-g)
41995-1	Pel-Freez	1g	144.55 EUR
Troponin I protein (Skeletal Muscle) (Rabbit)
30-1015	Fitzgerald	100 ug	582 EUR
Description: Purified native Rabbit Troponin I protein (Skeletal Muscle)
Troponin C protein (Skeletal Muscle) (Rabbit)
30-1020	Fitzgerald	1 mg	1059.6 EUR
Description: Purified native Rabbit Troponin C protein (Skeletal Muscle)
Rabbit Enolase, Muscle Specific (MSE) Protein
20-abx066421	Abbexa	794.40 EUR 326.40 EUR 2448.00 EUR 944.40 EUR 577.20 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
alpha smooth muscle actin Rabbit pAb
A7248-100ul	Abclonal	100 ul	369.6 EUR
alpha smooth muscle actin Rabbit pAb
A7248-200ul	Abclonal	200 ul	550.8 EUR
alpha smooth muscle actin Rabbit pAb
A7248-20ul	Abclonal	20 ul	219.6 EUR
alpha smooth muscle actin Rabbit pAb
A7248-50ul	Abclonal	50 ul	267.6 EUR
alpha smooth muscle Actin Rabbit mAb
A17910	Abclonal	20 μL	18 EUR
alpha smooth muscle Actin Rabbit mAb
A17910-100ul	Abclonal	100 ul	492 EUR
alpha smooth muscle Actin Rabbit mAb
A17910-200ul	Abclonal	200 ul	685.2 EUR
alpha smooth muscle Actin Rabbit mAb
A17910-20ul	Abclonal	20 ul	265.2 EUR
alpha smooth muscle Actin Rabbit mAb
A17910-50ul	Abclonal	50 ul	344.4 EUR
Rabbit Phosphofructokinase, Muscle (PFKM) ELISA Kit
abx363038-96tests	Abbexa	96 tests	990 EUR
Rabbit Skeletal Muscle Troponin-C Protein
20-abx260177	Abbexa	1646.40 EUR 393.60 EUR 1028.40 EUR	10 mg 1 mg 5 mg
Rabbit Creatine Kinase, Muscle (CKM) Protein
20-abx653071	Abbexa	777.60 EUR 326.40 EUR 2397.60 EUR 927.60 EUR 560.40 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Rabbit Anti Actin (Muscle) Polyclonal Antibody
CPBT-68162RA	Creative Diagnostics	0.5 ml	1057.2 EUR
Rabbit Glycogen Phosphorylase, Muscle ELISA kit
E04P0170-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Glycogen Phosphorylase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Glycogen Phosphorylase, Muscle ELISA kit
E04P0170-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Glycogen Phosphorylase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Glycogen Phosphorylase, Muscle ELISA kit
E04P0170-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Glycogen Phosphorylase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Eye muscle antibody ELISA kit
E04E0148-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Eye muscle antibody ELISA kit
E04E0148-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Eye muscle antibody ELISA kit
E04E0148-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Creatine Kinase, Muscle ELISA kit
E04C0400-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Creatine Kinase, Muscle ELISA kit
E04C0400-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Creatine Kinase, Muscle ELISA kit
E04C0400-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Cofilin 2, Muscle ELISA kit
E04C0470-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Cofilin 2, Muscle ELISA kit
E04C0470-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Cofilin 2, Muscle ELISA kit
E04C0470-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Phosphofructocinase Muscle(PFKM) ELISA Kit
QY-E30328	Qayee Biotechnology	96T	448.8 EUR
Creatine Kinase (CK/CPK), Rabbit Muscle
P1301-1	Biovision	each	164.4 EUR
Creatine Kinase (CK/CPK), Rabbit Muscle
P1301-25	Biovision	each	679.2 EUR
J Young Schlenk Cap B19
NMR1107	Scientific Laboratory Supplies	EACH	16.18 EUR
J Young Schlenk Cap B24
NMR1108	Scientific Laboratory Supplies	EACH	16.92 EUR
J Young Schlenk Cap B29
NMR1109	Scientific Laboratory Supplies	EACH	17.69 EUR
Human Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells
9-80100	CHI Scientific	1 x 100 ml	Ask for price
Mouse Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells
9-80198	CHI Scientific	1 x 100 ml	Ask for price
Rat Bladder Tissue Preparation Buffer 3: Normal Smooth Muscle Cells
9-80215	CHI Scientific	1 x 100 ml	Ask for price
Rat Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells
9-80288	CHI Scientific	1 x 100 ml	Ask for price
Total Protein from Human Adult Normal Tissue: Heart: Papilla Muscle
P1234132	Biochain	1 mg	596.4 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Human Soft Tissue Slide (Skeletal Muscle Normal) (5 slides/pk)
HTS-12341	Alpha Diagnostics	1 pk	343.2 EUR
Human Soft Tissue Slide (Skeletal Muscle Benign) (5 slides/pk)
HTS-12343	Alpha Diagnostics	1 pk	343.2 EUR
Human Soft Tissue Slide (Skeletal Muscle Malignant) (5 slides/pk)
HTS-12345	Alpha Diagnostics	1 pk	343.2 EUR
Total RNA from Human Adult Normal Tissue: Heart: Papilla Muscle
R1234132-10	Biochain	10 ug	232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Rabbit PSOAS MUSCLE YG FROZEN 1 EA
41217-1	Pel-Freez	1 Each	216.34 EUR
Rabbit PSOAS MUSCLE YG FRESH 1 EA
41217-2CC	Pel-Freez	1 Each	234.6 EUR
Rabbit Creatine Kinase, Muscle (CKM) ELISA Kit
20-abx155049	Abbexa	8684.40 EUR 4626.00 EUR 1074.00 EUR	10 × 96 tests 5 × 96 tests 96 tests
Rabbit Glycogen Phosphorylase, Muscle (PYGM) ELISA Kit
abx362756-96tests	Abbexa	96 tests	990 EUR
Rabbit Pyruvate Kinase, Muscle (PKM) ELISA Kit
abx363287-96tests	Abbexa	96 tests	990 EUR
Rabbit Smooth Muscle Myosin (SMM) ELISA Kit
abx363652-96tests	Abbexa	96 tests	990 EUR
Rabbit Creatine Kinase, Muscle (CKM) CLIA Kit
20-abx491038	Abbexa	10282.80 EUR 5472.00 EUR 1262.40 EUR	10 × 96 tests 5 × 96 tests 96 tests
Rabbit Creatine Kinase, Muscle (CKM) ELISA Kit
DLR-CKM-Rb-48T	DL Develop	48T	609.6 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Creatine Kinase, Muscle (CKM) in samples from serum, plasma or other biological fluids.
Rabbit Creatine Kinase, Muscle (CKM) ELISA Kit
DLR-CKM-Rb-96T	DL Develop	96T	793.2 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Creatine Kinase, Muscle (CKM) in samples from serum, plasma or other biological fluids.
Rabbit Anti Smooth Muscle Antibody ELISA kit
E04A0436-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Anti Smooth Muscle Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Anti Smooth Muscle Antibody ELISA kit
E04A0436-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Anti Smooth Muscle Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Anti Smooth Muscle Antibody ELISA kit
E04A0436-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Anti Smooth Muscle Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Alpha Smooth Muscle Actin ELISA kit
E04S0004-192T	BlueGene	192 tests	1524 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Alpha Smooth Muscle Actin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Il processo di degradazione ha interessato principalmente la porzione 4,4-dimetil-3,4-diidro-2H-tiopirano. I frammenti più suscettibili all’ossidazione erano i gruppi metilici e l’atomo di zolfo. Inoltre, in presenza di sulisobenzone, sotto irradiazione UV, il tazarotene è stato sottoposto ad un processo di degradazione, che ha portato a due prodotti di fotodecomposizione. Studi in silico eseguiti da OSIRIS Property Explorer hanno dimostrato che cinque dei prodotti di degradazione potrebbero essere dannosi in termini di effetti riproduttivi, che sono associati a 3,4-diidro-6-metil-2H-1-benzotiopirano 1,1-diossido, mentre uno di loro ha dimostrato una potenziale attività irritante. Le proprietà citotossiche dei prodotti di degradazione del tazarotene sono state valutate mediante dosaggio MTT su un pannello di cellule cancerose umane aderenti. L’inibizione della crescita dipendente dal tempo e dalla concentrazione è stata evidenziata nelle linee cellulari di cancro dell’ovaio (A2780) e della mammella (MDA-MB-231). La potenziale implicazione dei risultati della presente ricerca richiede ulteriori studi riguardanti principalmente la fotostabilità del tazarotene nelle formulazioni topiche.