Una preoccupazione per il crescente uso di farmaci da prescrizione durante la gravidanza è il rischio teratogeno. Questo rischio non è determinato per la maggior parte dei farmaci approvati negli Stati Uniti (USA) dal 2000 al 2010. L’acne e la psoriasi sono malattie croniche che si verificano tipicamente durante l’età fertile e poiché i retinoidi topici sono raccomandati sia per il trattamento dell’acne che per la psoriasi, è è possibile che le donne siano esposte a un retinoide topico durante la gravidanza. Gli studi di farmacocinetica mostrano un’esposizione sistemica relativamente bassa ai retinoidi topici, ma i livelli di esposizione che potrebbero portare a teratogenicità nell’uomo non sono noti. Il tazarotene, un retinoide topico, è stato approvato dalla Food and Drug Administration (FDA) statunitense sia per l’acne che per la psoriasi utilizzando i dati di farmacocinetica degli studi sulla psoriasi, che hanno stimato i dati basati sull’uso del tazarotene fino al 20% della superficie corporea.
Pertanto, sia in base all’etichettatura della gravidanza precedente che in quella attuale della FDA, il tazarotene non è raccomandato per l’uso durante la gravidanza. L’obiettivo di questa revisione della letteratura era fornire un contesto storico per la regola di etichettatura della gravidanza per il tazarotene rispetto ad altri retinoidi approvati e raccogliere i dati disponibili sugli esiti della gravidanza correlati a tazarotene e retinoidi. Sebbene vi siano segnalazioni di casi di esposizione topica alla tretinoina e all’adapalene in utero, non è chiaro se entrambe abbiano influenzato lo sviluppo fetale. In termini di tazarotene topico, ci sono attualmente dati limitati sugli esiti della gravidanza dopo l’esposizione in utero. Sono necessari ulteriori case report e studi sui risultati per esplorare ulteriormente la sicurezza del tazarotene topico in gravidanza.
La chemerina è indotta nella steatosi epatica non alcolica e nel carcinoma epatocellulare correlato all’epatite B
Chemerin è protettivo nei modelli sperimentali di carcinoma epatocellulare (HCC). Degno di nota, l’mRNA e le proteine della chemerina sono stati ridotti nei tessuti HCC di pazienti asiatici con eziologia per lo più della malattia da epatite B. L’attuale studio ha tuttavia dimostrato che la proteina chemerina è stata indotta nei tessuti tumorali di pazienti europei con HCC con steatosi epatica non alcolica (NAFLD) e pazienti con eziologia della malattia poco chiara. Una regolazione simile è stata osservata nel virus dell’epatite B (HBV), ma non nel virus dell’epatite C (HCV), HCC correlato. L’apparente discrepanza tra la regolazione della chemerina nell’HBV-HCC ottenuta dal nostro studio e rapporti recenti ci ha portato ad utilizzare gli anticorpi chemerina applicati nei saggi precedenti. Questi anticorpi non sono stati in grado di rilevare ugualmente diverse isoforme di chemerina, che erano sovraespresse nelle cellule HepG2.
Tuttavia, l’uso di tutti gli anticorpi ha confermato la presenza di una maggiore proteina chemerina nell’HCC. La proteina chemerina era bassa nelle cellule Huh7 e PLC / PRF / 5, mentre le cellule HepG2 e Hep3B avevano una proteina chemerina simile agli epatociti umani primari. Inoltre, gli effetti antitumorali dei retinoidi nelle linee cellulari degli epatociti non includevano la sovraregolazione della chemerina, che è stata inizialmente scoperta come proteina indotta dal tazarotene nella pelle. Infine, i livelli di proteine del recettore delle chemerine, il recettore 1 simile alle chemochine (CMKLR1), sono diminuiti nei tessuti non virali e tendevano ad essere inferiori nei tessuti HBV-HCC, suggerendo una ridotta attività delle chemerine nei tumori. Per riassumere, il nostro lavoro ha mostrato una regolazione opposta di chemerina e CMKLR1 in NAFLD e HCC associato a HBV. Nell’HCV-HCC né la chemerina né il suo recettore sono stati modificati nei tessuti tumorali. I risultati attuali non supportano un ruolo critico dei livelli di proteine totali delle chemerine nell’HCC di eziologia non virale e virale. Di conseguenza, la proteina chemerina localizzata nel tumore non era associata alla classificazione delle metastasi del nodo tumorale.
Test di fotostabilità di un retinoide-tazarotene di terza generazione in presenza di assorbitori UV
L’esposizione di un farmaco all’irradiazione UV potrebbe influire sulle sue proprietà fisico-chimiche. Pertanto, il test di fotostabilità è essenziale per i farmaci somministrati per via topica. Il tazarotene, un retinoide di terza generazione selettivo per i recettori, è comunemente usato per curare l’acne vulgaris e la psoriasi. Nel presente studio è stata eseguita un’analisi approfondita della fotostabilità del tazarotene in soluzione etanolica in presenza di ossido di zinco e / o biossido di titanio e filtri UV di tipo benzofenone. Undici presunti prodotti sono stati derivati dalla degradazione fotocatalitica del tazarotene utilizzando la cromatografia liquida ad alte prestazioni-spettrometria di massa tandem e sono stati proposti percorsi di trasformazione.
Soft Tissue Tissue Slide (Skeletal Muscle-Normal) |
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| MBS154227-4um | MyBiosource | 4um | 195 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-Normal) |
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| MBS154227-5x10um | MyBiosource | 5x10um | 920 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-Benign) |
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| MBS154290-10um | MyBiosource | 10um | 210 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-Benign) |
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| MBS154290-4um | MyBiosource | 4um | 195 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-Benign) |
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| MBS154290-5x10um | MyBiosource | 5x10um | 920 EUR |
Rat Skeletal Muscle Tissue Lysate |
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| IRTSKMTL100UG | Innovative research | each | 245 EUR |
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Description: Rat Skeletal Muscle Tissue Lysate |
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Rat Skeletal Muscle Tissue Lysate |
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| LYSATE0010 | BosterBio | 200ug | 180 EUR |
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Description: This cell lysate is prepared from rat skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C. |
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Rat Skeletal Muscle Tissue Lysate |
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| MBS8421547-01mg | MyBiosource | 0.1mg | 385 EUR |
Rat Skeletal Muscle Tissue Lysate |
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| MBS8421547-5x01mg | MyBiosource | 5x0.1mg | 1540 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-malignant) |
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| 12-345-10um | ProSci | 10 um | 241.8 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-malignant) |
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| 12-345-4um | ProSci | 4 um | 216.6 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-malignant) |
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| MBS154272-10um | MyBiosource | 10um | 210 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-malignant) |
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| MBS154272-4um | MyBiosource | 4um | 195 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-malignant) |
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| MBS154272-5x10um | MyBiosource | 5x10um | 920 EUR |
Mouse Skeletal Muscle Tissue Lysate |
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| IMSSKMTL100UG | Innovative research | each | 245 EUR |
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Description: Mouse Skeletal Muscle Tissue Lysate |
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Human Skeletal Muscle Tissue Lysate |
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| IHUSKMTL100UG | Innovative research | each | 245 EUR |
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Description: Human Skeletal Muscle Tissue Lysate |
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Mouse Skeletal Muscle Tissue Lysate |
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| LYSATE0021 | BosterBio | 200ug | 180 EUR |
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Description: This cell lysate is prepared from mouse skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C. |
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Human Skeletal Muscle Tissue Lysate |
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| MBS8419499-01mg | MyBiosource | 0.1mg | 385 EUR |
Human Skeletal Muscle Tissue Lysate |
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| MBS8419499-5x01mg | MyBiosource | 5x0.1mg | 1540 EUR |
Mouse Skeletal Muscle Tissue Lysate |
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| MBS8420876-01mg | MyBiosource | 0.1mg | 385 EUR |
Mouse Skeletal Muscle Tissue Lysate |
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| MBS8420876-5x01mg | MyBiosource | 5x0.1mg | 1540 EUR |
Bovine Skeletal Muscle Tissue Lysate |
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| MBS136285-01mg | MyBiosource | 0.1mg | 745 EUR |
Bovine Skeletal Muscle Tissue Lysate |
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| MBS136285-5x01mg | MyBiosource | 5x0.1mg | 3165 EUR |
Bovine Skeletal Muscle Tissue Lysate |
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| IBOSKMTL100UG | Innovative research | each | 541 EUR |
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Description: Bovine Skeletal Muscle Tissue Lysate |
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41225-2 RB MUSCLE TISSUE YG (1-kg) |
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| 41225-2 | Pel-Freez | 1 kg | 225 EUR |
41325-2 RB MUSCLE TISSUE MT FROZEN 1kg |
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| 41325-2 | Pel-Freez | 1 kg | 225 EUR |
Rat Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells |
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| 9-80281 | CHI Scientific | 1 x 100 ml | 132.3 EUR |
Human Diabetes Skeletal Muscle Tissue Lysate |
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| IHUSKMDIBTL100UG | Innovative research | each | 1413 EUR |
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Description: Human Diabetes Skeletal Muscle Tissue Lysate |
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Human Diabetes Skeletal Muscle Tissue Lysate |
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| MBS8419496-01mg | MyBiosource | 0.1mg | 1810 EUR |
Human Diabetes Skeletal Muscle Tissue Lysate |
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| MBS8419496-5x01mg | MyBiosource | 5x0.1mg | 7965 EUR |
Smooth muscle and striated muscle disease spectrum tissue array |
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| SO8011 | TissueArray | each | 414 EUR |
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Description: Smooth muscle and striated muscle disease spectrum tissue array, including TNM and clinical stage, 80 cases /80 cores |
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Human Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells |
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| 9-80092 | CHI Scientific | 1 x 100 ml | 160.65 EUR |
Mouse Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells |
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| 9-80189 | CHI Scientific | 1 x 100 ml | 160.65 EUR |
Rat Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells |
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| 9-80280 | CHI Scientific | 1 x 100 ml | 132.3 EUR |
Human Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells |
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| 9-80091 | CHI Scientific | 1 x 100 ml | 160.65 EUR |
Mouse Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells |
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| 9-80188 | CHI Scientific | 1 x 100 ml | 160.65 EUR |
Monkey Cynomolgus Skeletal Muscle Tissue Lysate |
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| IMNCYSKMTL100UG | Innovative research | each | 541 EUR |
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Description: Monkey Cynomolgus Skeletal Muscle Tissue Lysate |
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Monkey Cynomolgus Skeletal Muscle Tissue Lysate |
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| MBS8420209-INQUIRE | MyBiosource | INQUIRE | Ask for price |
cDNA - Rat Normal Tissue: Skeletal Muscle |
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| C1434171 | Biochain | 40 reactions | 311.5 EUR |
cDNA - Dog Normal Tissue: Skeletal Muscle |
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| C1734171 | Biochain | 40 reactions | 311.5 EUR |
Rhabdomyosarcoma with striated muscle tissue array |
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| SO2082b | TissueArray | each | 546 EUR |
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Description: Rhabdomyosarcoma with striated muscle tissue array, including TNM and clinical stage, 104 cases/208 cores, replacing SO2082a |
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Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array |
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| SO2081 | TissueArray | each | 474 EUR |
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Description: Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array, 104 cases/208 cores |
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cDNA - Human Tumor Tissue: Skeletal Muscle |
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| C1235171-10 | Biochain | 10 reactions | 221.2 EUR |
Rat Skeletal Muscle Whole tissue lysate |
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| RAL-1467 | Alpha Diagnostics | 1 mg | 628.8 EUR |
cDNA - Mouse Normal Tissue: Skeletal Muscle |
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| C1334171 | Biochain | 40 reactions | 311.5 EUR |
Human Skeletal Muscle Fetal Tissue Lysate |
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| IHUSKMFSTL100UG | Innovative research | each | 541 EUR |
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Description: Human Skeletal Muscle Fetal Tissue Lysate |
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Mouse Skeletal Muscle Whole tissue lysate |
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| MAL-1407 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Genomic DNA - Rat Normal Tissue: Skeletal Muscle |
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| D1434171 | Biochain | 100 ug | 241.5 EUR |
cDNA - Human Adult Normal Tissue: Skeletal Muscle |
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| C1234171 | Biochain | 40 reactions | 311.5 EUR |
Genomic DNA - Mouse Normal Tissue: Skeletal Muscle |
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| D1334171 | Biochain | 100 ug | 241.5 EUR |
cDNA - Monkey (Rhesus) Normal Tissue: Skeletal Muscle |
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| C1534171 | Biochain | 40 reactions | 353.5 EUR |
Tissue, Total Protein, Human Tumor, Skeletal Muscle |
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| MBS657457-1mg | MyBiosource | 1mg | 680 EUR |
Tissue, Total Protein, Human Tumor, Skeletal Muscle |
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| MBS657457-5x1mg | MyBiosource | 5x1mg | 2835 EUR |
cDNA - Human Diabetic Diseased Tissue: Skeletal Muscle |
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| C1236171Dia | Biochain | 40 reactions | 589.4 EUR |
cDNA - Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle |
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| C1534171-Cy | Biochain | 40 reactions | 353.5 EUR |
Human Liver Cirrhosis Muscle Diaphragm Tissue Lysate |
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| IHUMSCDPHCIRTL100UG | Innovative research | each | 1413 EUR |
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Description: Human Liver Cirrhosis Muscle Diaphragm Tissue Lysate |
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Human Liver Cirrhosis Muscle Diaphragm Tissue Lysate |
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| MBS8415535-01mg | MyBiosource | 0.1mg | 1810 EUR |
Human Liver Cirrhosis Muscle Diaphragm Tissue Lysate |
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| MBS8415535-5x01mg | MyBiosource | 5x0.1mg | 7965 EUR |
Rat Muscle OptiTDS™1: Tissue Dissociation System |
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| 4-28280 | CHI Scientific | 1 Kit | 255.15 EUR |
Rat Muscle OptiTDS™2: Tissue Dissociation System |
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| 4-28281 | CHI Scientific | 1 Kit | 255.15 EUR |
Human Muscle OptiTDS™1: Tissue Dissociation System |
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| 4-28091 | CHI Scientific | 1 Kit | 274.05 EUR |
Human Muscle OptiTDS™2: Tissue Dissociation System |
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| 4-28092 | CHI Scientific | 1 Kit | 274.05 EUR |
Mouse Muscle OptiTDS™1: Tissue Dissociation System |
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| 4-28188 | CHI Scientific | 1 Kit | 255.15 EUR |
Mouse Muscle OptiTDS™2: Tissue Dissociation System |
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| 4-28189 | CHI Scientific | 1 Kit | 255.15 EUR |
Human Adult Skeletal Muscle (Normal) Whole tissue lysate |
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| HAL-1375 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Monkey (Cyno.) Normal Skeletal Muscle Whole tissue lysate |
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| MCL-1197 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Tissue, Total Protein, Mouse Adult Normal, Skeletal Muscle |
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| MBS657016-1mg | MyBiosource | 1mg | 565 EUR |
Tissue, Total Protein, Mouse Adult Normal, Skeletal Muscle |
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| MBS657016-5x1mg | MyBiosource | 5x1mg | 2315 EUR |
Tissue, Total Protein, Human Adult Normal, Skeletal Muscle |
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| MBS657322-1mg | MyBiosource | 1mg | 565 EUR |
Tissue, Total Protein, Human Adult Normal, Skeletal Muscle |
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| MBS657322-5x1mg | MyBiosource | 5x1mg | 2315 EUR |
Tissue, Section, Human Adult Normal, Skeletal Muscle (Frozen) |
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| MBS640631-5Sections | MyBiosource | 5Sections | 635 EUR |
Tissue, Section, Human Adult Normal, Skeletal Muscle (Frozen) |
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| MBS640631-5x5Sections | MyBiosource | 5x5Sections | 2640 EUR |
Monkey (Rhesus) Normal Skeletal Muscle Whole tissue lysate |
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| MRL-1247 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Tissue, Section, Human Adult Normal, Skeletal Muscle (Paraffin) |
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| MBS640137-5Sections | MyBiosource | 5Sections | 460 EUR |
Tissue, Section, Human Adult Normal, Skeletal Muscle (Paraffin) |
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| MBS640137-5x5Sections | MyBiosource | 5x5Sections | 1925 EUR |
Tissue, Membrane Protein, Human Adult Normal, Skeletal Muscle |
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| MBS639871-01mg | MyBiosource | 0.1mg | 570 EUR |
Tissue, Membrane Protein, Human Adult Normal, Skeletal Muscle |
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| MBS639871-5x01mg | MyBiosource | 5x0.1mg | 2345 EUR |
Tissue, Total Protein, Human Disease, Diabetes, Skeletal Muscle |
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| MBS657193-1mg | MyBiosource | 1mg | 820 EUR |
Tissue, Total Protein, Human Disease, Diabetes, Skeletal Muscle |
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| MBS657193-5x1mg | MyBiosource | 5x1mg | 3470 EUR |
Tissue, Section, Human Disease, Diabetes, Skeletal Muscle (Frozen) |
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| MBS640417-5Slides | MyBiosource | 5Slides | 755 EUR |
Tissue, Section, Human Disease, Diabetes, Skeletal Muscle (Frozen) |
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| MBS640417-5x5Slides | MyBiosource | 5x5Slides | 3170 EUR |
Tissue, Membrane Protein, Human Disease, Diabetes, Skeletal Muscle |
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| MBS639800-01mg | MyBiosource | 0.1mg | 695 EUR |
Tissue, Membrane Protein, Human Disease, Diabetes, Skeletal Muscle |
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| MBS639800-5x01mg | MyBiosource | 5x0.1mg | 2915 EUR |
Tissue, Section, Human Disease, Diabetes, Skeletal Muscle (Paraffin) |
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| MBS640643-5Slides | MyBiosource | 5Slides | 510 EUR |
Tissue, Section, Human Disease, Diabetes, Skeletal Muscle (Paraffin) |
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| MBS640643-5x5Slides | MyBiosource | 5x5Slides | 2145 EUR |
Tissue, Total Protein, Human Adult Normal, Heart, Papilla Muscle |
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| MBS657154-1mg | MyBiosource | 1mg | 860 EUR |
Tissue, Total Protein, Human Adult Normal, Heart, Papilla Muscle |
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| MBS657154-5x1mg | MyBiosource | 5x1mg | 3640 EUR |
Tissue, Total RNA, Rat Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638559-005mg | MyBiosource | 0.05mg | 435 EUR |
Tissue, Total RNA, Rat Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638559-5x005mg | MyBiosource | 5x0.05mg | 1735 EUR |
Human Soft Tissue Slide (Skeletal Muscle Normal) (5 slides/pk) |
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| HTS-12341 | Alpha Diagnostics | 1 pk | 343.2 EUR |
Human Soft Tissue Slide (Skeletal Muscle Benign) (5 slides/pk) |
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| HTS-12343 | Alpha Diagnostics | 1 pk | 343.2 EUR |
Skeletal Muscle Tissue Slides, Normal Rat Paraffin Sections, 5 slides/pack |
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| TS-R5410 | IHC World | - | 145 EUR |
Tissue, Section, Human Adult Normal, Heart, Papilla Muscle (Paraffin) |
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| MBS640350-5Sections | MyBiosource | 5Sections | 460 EUR |
Tissue, Section, Human Adult Normal, Heart, Papilla Muscle (Paraffin) |
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| MBS640350-5x5Sections | MyBiosource | 5x5Sections | 1925 EUR |
Tissue, Total RNA, Mouse, Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638546-005mg | MyBiosource | 0.05mg | 435 EUR |
Tissue, Total RNA, Mouse, Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638546-5x005mg | MyBiosource | 5x0.05mg | 1735 EUR |
Tissue, Total RNA, Human Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638548-005mg | MyBiosource | 0.05mg | 495 EUR |
Tissue, Total RNA, Human Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638548-5x005mg | MyBiosource | 5x0.05mg | 1995 EUR |
Tissue, Genomic DNA, Rat Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS654525-01mg | MyBiosource | 0.1mg | 575 EUR |
Tissue, Genomic DNA, Rat Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS654525-5x01mg | MyBiosource | 5x0.1mg | 2440 EUR |
Tissue, Total RNA, Human Adult Normal, Muscle, Diaphragm, BioGenomics |
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| MBS638673-001mg | MyBiosource | 0.01mg | 485 EUR |
Tissue, Total RNA, Human Adult Normal, Muscle, Diaphragm, BioGenomics |
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| MBS638673-5x001mg | MyBiosource | 5x0.01mg | 1960 EUR |
Tissue cDNA, First Strand, Human Tumor, Skeletal Muscle, BioGenomics |
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| MBS652570-10Tests | MyBiosource | 10Tests | 570 EUR |
Tissue cDNA, First Strand, Human Tumor, Skeletal Muscle, BioGenomics |
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| MBS652570-5x10Tests | MyBiosource | 5x10Tests | 2345 EUR |
Human Soft Tissue Slide (Skeletal Muscle Malignant) (5 slides/pk) |
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| HTS-12345 | Alpha Diagnostics | 1 pk | 343.2 EUR |
Skeletal Muscle Tissue Slides, Normal Human Paraffin Sections, 5 slides/pack |
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| TS-H5019 | IHC World | - | 145 EUR |
Skeletal Muscle Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack |
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| TS-M5208 | IHC World | - | 145 EUR |
Tissue, Genomic DNA, Human Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS654357-01mg | MyBiosource | 0.1mg | 575 EUR |
Tissue, Genomic DNA, Human Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS654357-5x01mg | MyBiosource | 5x0.1mg | 2440 EUR |
Tissue, Genomic DNA, Mouse Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS654457-01mg | MyBiosource | 0.1mg | 575 EUR |
Tissue, Genomic DNA, Mouse Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS654457-5x01mg | MyBiosource | 5x0.1mg | 2440 EUR |
Rat Bladder Tissue Preparation Buffer 3: Normal Smooth Muscle Cells |
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| 9-80215 | CHI Scientific | 1 x 100 ml | 132.3 EUR |
Rat Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells |
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| 9-80288 | CHI Scientific | 1 x 100 ml | 132.3 EUR |
Tissue cDNA, First Strand, Rat Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS651951-40Tests | MyBiosource | 40Tests | 680 EUR |
Tissue cDNA, First Strand, Rat Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS651951-5x40Tests | MyBiosource | 5x40Tests | 2835 EUR |
Tissue Set, BioAssay, DNA, RNA, Protein, Rat Adult Normal, Skeletal Muscle |
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| MBS640974-1Set | MyBiosource | 1Set | 650 EUR |
Tissue Set, BioAssay, DNA, RNA, Protein, Rat Adult Normal, Skeletal Muscle |
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| MBS640974-5x1Set | MyBiosource | 5x1Set | 2970 EUR |
Human Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells |
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| 9-80100 | CHI Scientific | 1 x 100 ml | 160.65 EUR |
Mouse Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells |
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| 9-80198 | CHI Scientific | 1 x 100 ml | 160.65 EUR |
Tissue, Total RNA, Monkey (Rhesus) Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638519-005mg | MyBiosource | 0.05mg | 485 EUR |
Tissue, Total RNA, Monkey (Rhesus) Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS638519-5x005mg | MyBiosource | 5x0.05mg | 1960 EUR |
Tissue cDNA, First Strand, Mouse Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS652206-40Tests | MyBiosource | 40Tests | 680 EUR |
Tissue cDNA, First Strand, Mouse Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS652206-5x40Tests | MyBiosource | 5x40Tests | 2835 EUR |
Tissue cDNA, First Strand, Canine Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS652356-40Tests | MyBiosource | 40Tests | 680 EUR |
Tissue cDNA, First Strand, Canine Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS652356-5x40Tests | MyBiosource | 5x40Tests | 2835 EUR |
Tissue cDNA, First Strand, Human Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS652565-40Tests | MyBiosource | 40Tests | 680 EUR |
Tissue cDNA, First Strand, Human Adult Normal, Skeletal Muscle, BioGenomics |
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| MBS652565-5x40Tests | MyBiosource | 5x40Tests | 2835 EUR |
Tissue Set, BioAssay, DNA, RNA, Protein, Human Adult Normal, Skeletal Muscle |
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| MBS639731-1Kit | MyBiosource | 1Kit | 730 EUR |
Tissue Set, BioAssay, DNA, RNA, Protein, Human Adult Normal, Skeletal Muscle |
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| MBS639731-5x1Kit | MyBiosource | 5x1Kit | 3075 EUR |
Tissue Set, BioAssay, DNA, RNA, Protein, Mouse Adult Normal, Skeletal Muscle |
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| MBS640983-1Set | MyBiosource | 1Set | 650 EUR |
Tissue Set, BioAssay, DNA, RNA, Protein, Mouse Adult Normal, Skeletal Muscle |
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| MBS640983-5x1Set | MyBiosource | 5x1Set | 2970 EUR |
Tissue, Array, Rat Adult Normal, Multi, tissue I, heart, brain, kidney, liver, lung, spleen, small intestine, skeletal muscle |
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| MBS639715-5Arrays | MyBiosource | 5Arrays | 510 EUR |
Tissue, Array, Rat Adult Normal, Multi, tissue I, heart, brain, kidney, liver, lung, spleen, small intestine, skeletal muscle |
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| MBS639715-5x5Arrays | MyBiosource | 5x5Arrays | 2145 EUR |
Rat Heart Tissue Preparation Buffer 1: Normal Aortic Smooth Muscle Cells |
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| 9-80253 | CHI Scientific | 1 x 100 ml | 132.3 EUR |
Tissue, Genomic DNA, Human Disease (Adult), Diabetes, Skeletal Muscle, BioGenomics |
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| MBS654386-005mg | MyBiosource | 0.05mg | 715 EUR |
Tissue, Genomic DNA, Human Disease (Adult), Diabetes, Skeletal Muscle, BioGenomics |
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| MBS654386-5x005mg | MyBiosource | 5x0.05mg | 3075 EUR |
Human Heart Tissue Preparation Buffer 1: Normal Aortic Smooth Muscle Cells |
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| 9-80066 | CHI Scientific | 1 x 100 ml | 160.65 EUR |
Mouse Heart Tissue Preparation Buffer 1: Normal Aortic Smooth Muscle Cells |
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| 9-80159 | CHI Scientific | 1 x 100 ml | 160.65 EUR |
Rat Cervix Tissue Preparation Buffer 3: Normal Cervical Smooth Muscle Cells |
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| 9-80233 | CHI Scientific | 1 x 100 ml | 132.3 EUR |
Genomic DNA - Human Adult Normal Tissue: Skeletal Muscle, from a single donor |
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| D1234171 | Biochain | 100 ug | 241.5 EUR |
Human Bladder Tissue Preparation Buffer 3: Normal Bladder Smooth Muscle Cells |
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| 9-80009 | CHI Scientific | 1 x 100 ml | 160.65 EUR |
Human Cervix Tissue Preparation Buffer 3: Normal Cervical Smooth Muscle Cells |
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| 9-80046 | CHI Scientific | 1 x 100 ml | 160.65 EUR |
Mouse Cervix Tissue Preparation Buffer 3: Normal Cervical Smooth Muscle Cells |
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| 9-80139 | CHI Scientific | 1 x 100 ml | 160.65 EUR |
Rat Colon Tissue Preparation Buffer 2: Normal Colorectal Smooth Muscle Cells |
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| 9-80237 | CHI Scientific | 1 x 100 ml | 132.3 EUR |
Il processo di degradazione ha interessato principalmente la porzione 4,4-dimetil-3,4-diidro-2H-tiopirano. I frammenti più suscettibili all’ossidazione erano i gruppi metilici e l’atomo di zolfo. Inoltre, in presenza di sulisobenzone, sotto irradiazione UV, il tazarotene è stato sottoposto ad un processo di degradazione, che ha portato a due prodotti di fotodecomposizione. Studi in silico eseguiti da OSIRIS Property Explorer hanno dimostrato che cinque dei prodotti di degradazione potrebbero essere dannosi in termini di effetti riproduttivi, che sono associati a 3,4-diidro-6-metil-2H-1-benzotiopirano 1,1-diossido, mentre uno di loro ha dimostrato una potenziale attività irritante. Le proprietà citotossiche dei prodotti di degradazione del tazarotene sono state valutate mediante dosaggio MTT su un pannello di cellule cancerose umane aderenti. L’inibizione della crescita dipendente dal tempo e dalla concentrazione è stata evidenziata nelle linee cellulari di cancro dell’ovaio (A2780) e della mammella (MDA-MB-231). La potenziale implicazione dei risultati della presente ricerca richiede ulteriori studi riguardanti principalmente la fotostabilità del tazarotene nelle formulazioni topiche.
