Biomarcatori multipli per la previsione dei primi eventi cardiovascolari maggiori e decessi.

• Abbiamo misurato 10 biomarcatori su 3209 partecipanti al ciclo di routine Framingham Heart Study:  livelli di proteina C-reattiva, peptide natriuretico di tipo B, peptide natriuretico proprietario N-terminale, aldosterone, renina, fibrinogeno, D-dimero, inibitore dell’attivatore del plasminogeno di tipo 1 e omocisteina; e il rapporto tra albumina urinaria e creatinina.
• Podczas obserwacji (mediana 7,4 roku) zmarło 207 uczestników, au 169 wystąpiło pierwsze poważne zdarzenie sercowo-naczyniowe. W modelach proporcjonalnych zagrożeń Coxa z uwzględnieniem konwencjonalnych czynników ryzyka, następujące biomarkery najsilniej przewidywały ryzyko zgonu (po każdym biomarkerze następuje skorygowany współczynnik ryzyka na przyrost o 1 SD w wartościach log): Poziom peptydu natriuretycznego typu B (1,40) ), poziom białka C-reaktywnego (1,39), stosunek albuminy do kreatyniny w moczu (1,22), poziom homocysteiny (1,20) i poziom reniny (1,17).
• Biomarkerami, które najsilniej przewidywały poważne zdarzenia sercowo-naczyniowe, były poziom peptydów natriuretycznych typu B (skorygowany współczynnik ryzyka, 1,25 na przyrost 1 SD w wartościach log) oraz stosunek albuminy w moczu do kreatyniny (1,20). Osoby z punktacją „ multimarker ” (na podstawie współczynników regresji istotnych biomarkerów) w najwyższym kwintylu w porównaniu z osobami z wynikami w dwóch najniższych kwintylach miały podwyższone ryzyko zgonu (skorygowany współczynnik ryzyka, 4,08; p<0,001) i poważne zdarzenia sercowo-naczyniowe (skorygowany współczynnik ryzyka 1,84; P=0,02). Jednak dodanie wyników  wielomarkerowych  do konwencjonalnych czynników ryzyka spowodowało jedynie niewielki wzrost zdolności do klasyfikowania ryzyka, mierzonego statystyką C.
• Do oceny ryzyka u poszczególnych osób zastosowanie 10 współczesnych biomarkerów, które badaliśmy, dodaje tylko umiarkowanie do standardowych czynników ryzyka

Efficienza e potenza in genetica.

Abbiamo esaminato la selezione e l’analisi dei marcatori SNP per studi di associazione sull’intero genoma, esaminando in dettaglio la relazione tra investimento di genotipizzazione e potenza statistica. I metodi pairwise o  multimarker   massimizzano l’efficienza e la potenza? Quanta potenza è a rischio quando i tag vengono selezionati da una risorsa incompleta come HapMap? Abbiamo risposto a queste domande utilizzando i dati genotipici del progetto HapMap ENCODE, studi di associazione simulati in un modello di malattia realistico e aggiustamenti empirici per testare ipotesi multiple.Mostriamo un metodo di tagging basato sull’aplotipo che supera in modo uniforme i metodi di test e definizione delle priorità dei singoli marker che migliorano notevolmente l’efficienza di tagging. Testare tutti gli aplotipi osservati per l’associazione, non solo quelli che sono controparti di SNP noti, aumenta la capacità di rilevare alleli causali rari a scapito della potenza ridotta per rilevare alleli causali comuni. La potenza resiste alla completezza del pannello di riferimento da cui vengono selezionati i marker. Questi risultati sono importanti per dare priorità ai marcatori SNP e interpretare gli studi di associazione.

• GWAS è diventato uno strumento popolare per identificare le varianti genetiche associate al rischio di malattia. L’analisi dei casi di controllo GWAS standard include una valutazione dell’associazione tra ogni singolo SNP genotipizzato e il rischio di malattia.
• Questo approccio, tuttavia, ha una riproducibilità limitata e difficoltà nel rilevare effetti multi-SNP ed epistatici. Come strategia analitica alternativa, proponiamo di raggruppare gli SNP in insiemi di SNP in base alla vicinanza di caratteristiche genomiche come geni o blocchi di aplotipi e quindi testare l’effetto comune di ciascun insieme di SNP.
• Il test di ogni set di SNP viene eseguito con un test logistico basato sulla macchina del kernel che si basa su statistiche che consentono una modellazione flessibile degli effetti SNP epistatici e non lineari. Questa flessibilità e la capacità di adattarsi naturalmente agli effetti covariati sono caratteristiche importanti del nostro test che lo rendono interessante rispetto ai test SNP individuali e ai test  multimarcatori esistenti   .
• Utilizzando dati simulati basati sul progetto internazionale HapMap, dimostriamo che testare un insieme di SNP può essere più potente rispetto all’analisi standard di singoli SNP su un’ampia gamma di impostazioni.
• In particolare, troviamo che il nostro approccio è più potente dell’analisi di singoli SNP quando la correlazione mediana tra la variante di suscettibilità alla malattia e gli SNP genotipizzati è da moderata ad alta. Quando la correlazione è bassa,  sia l’analisi dei singoli SNP che l’analisi di un insieme di SNP sono generalmente a bassa potenza. Usiamo l’analisi del set SNP per analizzare i dati GWAS Discovery Phase (CGEMS) del cancro al seno.

Associazione ampia del genoma per la schizofrenia in CATIE: risultati dello stadio 1.

• Poco si sa con certezza sulla genetica della schizofrenia. L’emergere di associazioni a livello di genoma è stato ampiamente previsto come un modo promettente per identificare la variazione ripetitiva della sequenza del DNA associata a questo disturbo importante e devastante.
• Un totale di 738 casi di schizofrenia DSM-IV (tutti i partecipanti CATIE) e 733 gruppi di controllo abbinati sono stati genotipizzati per 492.900 polimorfismi a singolo nucleotide (SNP) utilizzando la piattaforma di genotipizzazione a doppio chip Affymetrix 500K e un’imbottitura personalizzata 164K. nel chip  .
• Dopo più fasi di controllo della qualità sia per i soggetti che per gli SNP, sono state utilizzate analisi di regressione logistica per valutare l’evidenza di un’associazione di tutti gli SNP con la schizofrenia. Abbiamo identificato una serie di SNP promettenti per il follow-up, sebbene nessun SNP o combinazione di  multimarcatori SNP abbia   raggiunto una significatività statistica a livello di genoma.
• Sebbene diversi segnali coincidano con regioni del genoma precedentemente coinvolte nella schizofrenia, una coincidenza non può essere esclusa. Questi dati non forniscono prove del coinvolgimento di alcuna regione genomica nella schizofrenia rilevabile alla dimensione media del campione.

SITVITWEB – un database internazionale pubblicamente accessibile di  multimarcatori   per lo studio della diversità genetica e dell’epidemiologia molecolare del Mycobacterium tuberculosis.

1. Tra i vari metodi di genotipizzazione per lo studio del polimorfismo genotipico del Mycobacterium tuberculosis complex (MTC), dello spoligotyping e delle unità ripetute intervallate da micobatteri, il numero variabile di ripetizioni di DNA in tandem (MIRU-VNTR) ha recentemente ottenuto l’approvazione internazionale come strumento robusto, veloce e riproducibile metodo di digitazione che genera dati in un formato portatile.
2. Lo spoligotyping era la spina dorsale del database SpolDB4 pubblicamente disponibile rilasciato nel 2006; tuttavia, questo metodo ha un basso potere discriminante se usato da solo e dovrebbe idealmente essere utilizzato insieme a un secondo metodo di tipizzazione come MIRU-VNTR per studi epidemiologici ad alta risoluzione.
3. Niniejszym opisujemy publicznie dostępną międzynarodową bazę danych o nazwie SITVITWEB, która zawiera takie  dane wielomarkerowe ,  które pozwalają uzyskać globalną wizję różnorodności genetycznej MTC na całym świecie, opartą na 62 582 izolatach klinicznych odpowiadających 153 krajom pochodzenia pacjentów (105 krajów izolacji).
4. Przedstawiamy łącznie 7105 wzorów spoligotypów (odpowiadających 58 180 izolatom klinicznym) – pogrupowanych na 2740 wspólnych typów lub międzynarodowych typów spoligotypów (SIT) zawierających 53 816 izolatów klinicznych i 4364 wzory sieroce.
5. Co ciekawe, tylko 7% izolatów MTC na całym świecie było sierotami, podczas gdy ponad połowa izolatów poddanych SIT (n=27059) była ograniczona tylko do 24 najbardziej rozpowszechnionych SIT. Baza danych zawiera również łącznie 2379 wzorów MIRU (z 8161 izolatów klinicznych) z 87 krajów pochodzenia pacjentów (35 krajów izolacji); zostały one pogrupowane w 847 wspólnych typów lub
6. Międzynarodowe typy MIRU (MIT) zawierające 6626 izolatów i 1533 wzory sieroce. Wreszcie, dane dotyczące dokładnych powtórzeń tandemowych (ETR) w 5 locus były dostępne dla 4626 izolatów z 59 krajów pochodzenia pacjentów (22 kraje izolacji); zaobserwowano łącznie 458 różnych wzorców VNTR – podzielonych na 245 wspólnych typów lub VNTR International Types (VIT) zawierających 4413 izolatów) i 213 wzorców sierocych.
7. Eksploracja danych w SITVITWEB umożliwiła ponadto aktualizację zasad definiujących linie genotypowe MTC, a także uzyskanie nowego wglądu w strukturę populacji MTC i rozmieszczenie na świecie na poziomie krajowym, subregionalnym i kontynentalnym.
8. Na poziomie ewolucyjnym zebrane dane mogą być przydatne do rozróżnienia okazjonalnej zbieżnej ewolucji genotypów od specyficznej ewolucji podlinii, na które zasadniczo wpływa adaptacja do gospodarza.

Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue IV (8), gallbladder, control, esophagus, control, stomach, control, lung, control (matched with Total RNA Northern Blot) (Paraffin)
MBS639509-5x5Arrays	MyBiosource	5x5Arrays	3465 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue II (8), esophagus, control, stomach, control, colon, control, rectum, control (matched with Total RNA Northern Blot) (Paraffin)
MBS639676-5Arrays	MyBiosource	5Arrays	805 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue II (8), esophagus, control, stomach, control, colon, control, rectum, control (matched with Total RNA Northern Blot) (Paraffin)
MBS639676-5x5Arrays	MyBiosource	5x5Arrays	3465 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue V (8), small intestine, control, esophagus, control, thymoma, control, lung, control (matched with Total RNA Northern Blot) (Paraffin)
MBS639572-5Arrays	MyBiosource	5Arrays	805 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue V (8), small intestine, control, esophagus, control, thymoma, control, lung, control (matched with Total RNA Northern Blot) (Paraffin)
MBS639572-5x5Arrays	MyBiosource	5x5Arrays	3465 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue III (8), kidney, control, oschea/ureter, control, bladder, control, stomach, control (matched with Total RNA Northern Blot) (Paraffin)
MBS639689-5Arrays	MyBiosource	5Arrays	805 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue III (8), kidney, control, oschea/ureter, control, bladder, control, stomach, control (matched with Total RNA Northern Blot) (Paraffin)
MBS639689-5x5Arrays	MyBiosource	5x5Arrays	3465 EUR
Breast Panel Multi-Tumor control slides, set of 5
TS901	Innovex	Set of 5	145 EUR
Breast Panel Multi-Tumor control slides, set of 25
TS901-25	Innovex	Set of 25	395 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue VI (8), breast, control, uterus, control, teratoma/fallopian tube, control, ovary, control (matched with Total RNA Northern Blot) (Paraffin)
MBS639445-5Arrays	MyBiosource	5Arrays	805 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue VI (8), breast, control, uterus, control, teratoma/fallopian tube, control, ovary, control (matched with Total RNA Northern Blot) (Paraffin)
MBS639445-5x5Arrays	MyBiosource	5x5Arrays	3465 EUR
Multiple lymphoma tissue array with normal tissue as control
LM481c	TissueArray	each	198 EUR
Multiple cancer tissue array with matched or unmatched normal control
MC802	TissueArray	each	306 EUR
Multiple pancreatic cancer with 4 normal tissues control from autopsy
PA481	TissueArray	each	138 EUR
Multiple cervix cancer tissue array with normal tissue control from autopsy
CR483	TissueArray	each	198 EUR
Multiple Kidney cancer tissue array with normal tissue control from autopsy
KD483	TissueArray	each	168 EUR
Multiple skin cancer tissue array with 4 normal tissue control from autopsy
SK482	TissueArray	each	168 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue I (5), colon, control, rectum, control, normal placenta (matched with mRNA blots) (Paraffin)
MBS639553-5Arrays	MyBiosource	5Arrays	765 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue I (5), colon, control, rectum, control, normal placenta (matched with mRNA blots) (Paraffin)
MBS639553-5x5Arrays	MyBiosource	5x5Arrays	3300 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue II (5), breast, control, uterus, control, normal placenta (matched with mRNA blots) (Paraffin)
MBS639454-5Arrays	MyBiosource	5Arrays	765 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue II (5), breast, control, uterus, control, normal placenta (matched with mRNA blots) (Paraffin)
MBS639454-5x5Arrays	MyBiosource	5x5Arrays	3300 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue III (5), kidney, control, lung, control, normal placenta (matched with mRNA blots) (Paraffin)
MBS639459-5Arrays	MyBiosource	5Arrays	765 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue III (5), kidney, control, lung, control, normal placenta (matched with mRNA blots) (Paraffin)
MBS639459-5x5Arrays	MyBiosource	5x5Arrays	3300 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue VI (5), ovary, control, uterus, control, normal placenta (matched with mRNA blots) (Paraffin)
MBS639469-5Arrays	MyBiosource	5Arrays	765 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue VI (5), ovary, control, uterus, control, normal placenta (matched with mRNA blots) (Paraffin)
MBS639469-5x5Arrays	MyBiosource	5x5Arrays	3300 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue V (5), liver, control, stomach, control, normal placenta (matched with mRNA blots) (Paraffin)
MBS639388-5Arrays	MyBiosource	5Arrays	765 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue V (5), liver, control, stomach, control, normal placenta (matched with mRNA blots) (Paraffin)
MBS639388-5x5Arrays	MyBiosource	5x5Arrays	3300 EUR
Multi normal & tumor, 12 cases (1.5mm)HumanMulti-systemMulti-organsIHC control
MNT242	Pantomics	1.5mm	50 EUR
Multiple liver cancer tissue array with 4 normal tissues control from autopsy
LV482	TissueArray	each	168 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue IV (5), bladder, control, esophagus, control, normal placenta (matched with mRNA blots) (Paraffin)
MBS639579-5Arrays	MyBiosource	5Arrays	765 EUR
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue IV (5), bladder, control, esophagus, control, normal placenta (matched with mRNA blots) (Paraffin)
MBS639579-5x5Arrays	MyBiosource	5x5Arrays	3300 EUR
Multiple cervix cancer tissue array with 4 normal tissues control from autopsy
CR482	TissueArray	each	198 EUR
Rat Sodium-dependent Multi-Vitamin Transporter (SMVT) ), control/blocking peptide # 1
SMVT11-P	Alpha Diagnostics	100 ug	196.8 EUR
Multiple organ digestive system diseased tissue array with normal tissue as control
BCC000128	TissueArray	each	198 EUR
Rat Pasteurella multocida Positive Control
MBS412069-1mL	MyBiosource	1mL	175 EUR
Rat Pasteurella multocida Positive Control
MBS412069-5x1mL	MyBiosource	5x1mL	645 EUR
Multiple parts of skin squamous cell carcinoma tissue array with normal tissues as control
SK483	TissueArray	each	168 EUR
Mouse Pasteurella multocida Positive Control
MBS412066-1mL	MyBiosource	1mL	175 EUR
Mouse Pasteurella multocida Positive Control
MBS412066-5x1mL	MyBiosource	5x1mL	645 EUR
Rabbit Pasteurella Multocida Positive Control
MBS412028-1mL	MyBiosource	1mL	175 EUR
Rabbit Pasteurella Multocida Positive Control
MBS412028-5x1mL	MyBiosource	5x1mL	645 EUR
Multiple organ cancer tissue array with matched non-metastatic lymph node tissue as control
NMET961	TissueArray	each	204 EUR
Mouse pasteurella multocida PCR Positive Control
MBS412577-025mL	MyBiosource	0.25mL	1500 EUR
Mouse pasteurella multocida PCR Positive Control
MBS412577-5x025mL	MyBiosource	5x0.25mL	6545 EUR
Multiple Tumor Tissue Array - 47 different tumors and their corresponding normal tissues, plus 2 control spots
T8235713-2	Biochain	2 slides	430 EUR
Multiple Tumor Tissue Array - 47 different tumors and their corresponding normal tissues, plus 2 control spots
T8235713-5	Biochain	5 slides	1085 EUR
Multiple Tumor Tissue Array - 12 types of human tissues in duplicates, designed as universal control for >90% routine IH
Z7020083	Biochain	5 slides	321.6 EUR
Multi-cable (for Controller & Chamber)
LBC12101	Westburg	each	503.58 EUR
Natriuretic Peptide Receptor B / PGCB Western Blot Positive Control
MBS543115-5Applications	MyBiosource	5Applications	350 EUR
Natriuretic Peptide Receptor B / PGCB Western Blot Positive Control
MBS543115-5x5Applications	MyBiosource	5x5Applications	1435 EUR
Natriuretic Peptide Receptor C Antibody Western Blot Positive Control
MBS542999-5Applications	MyBiosource	5Applications	335 EUR
Natriuretic Peptide Receptor C Antibody Western Blot Positive Control
MBS542999-5x5Applications	MyBiosource	5x5Applications	1350 EUR
Natriuretic Peptide Receptor C / PGCC Antibody Western Blot Positive Control
MBS543116-5Applications	MyBiosource	5Applications	350 EUR
Natriuretic Peptide Receptor C / PGCC Antibody Western Blot Positive Control
MBS543116-5x5Applications	MyBiosource	5x5Applications	1435 EUR
Immortalized Multimammate Mouse Skin Keratinocytes (Kera5)
T0763	ABM	1x10^6 cells / 1.0 ml	3950 EUR
Pasteurella multocida Type IV fimbrial subunit protein (PTFA) control peptide
PTFA16-P	Alpha Diagnostics	100 ug	562.8 EUR
NATtrol Norovirus Negative Control (6 x 0.125mL)
NATROTA-6MC	Zeptometrix	6 x 0.125mL	203 EUR
NATtrol Candida/TV Positive Control (ea)
NATCTVPOS-BD	Zeptometrix	ea	446 EUR
NATtrol Parainfluenza Control (6 X 0.5mL)
NATPIV-ERC	Zeptometrix	6 X 0.5mL	265 EUR
NATtrol BV Negative Control (6 X 0.15mL)
NATBVNEG-BD	Zeptometrix	6 X 0.15mL	295 EUR
NATtrol BV Positive Control (6 X 0.15mL)
NATBVPOS-BD	Zeptometrix	6 X 0.15mL	446 EUR
NATtrol RSV Positive Control (6 x 0.5mL)
NATRSV-6C	Zeptometrix	6 x 0.5mL	222 EUR
NATtrol Norovirus GI Positive Control (6 x 0.125mL)
NATNOVI-6MC	Zeptometrix	6 x 0.125mL	205 EUR
NATtrol AdV/hMPV/HRV Control (6 X 0.5mL)
NATAMR-ERC	Zeptometrix	6 X 0.5mL	227 EUR
NATtrol Norovirus GII Positive Control (6 x 0.125mL)
NATNOVII-6MC	Zeptometrix	6 x 0.125mL	205 EUR
NATtrol EV Negative Control (6 X 0.2 mL)
NATEVNEG-6MC	Zeptometrix	6 X 0.2 mL	208 EUR
NATtrol EV Positive Control (6 X 0.2 mL)
NATEVPOS-6MC	Zeptometrix	6 X 0.2 mL	208 EUR
NATtrol SA Positive Control (6 X 0.5 mL)
NATMSSA-6MC	Zeptometrix	6 X 0.5 mL	311 EUR
NATtrol SA Positive Control  (6 X 0.5 mL)
NATMSSA-6MC-IVD	Zeptometrix	6 X 0.5 mL	331 EUR
NATtrol EV Positive Control (6 X 0.5 mL)
MDZ055	Zeptometrix	6 X 0.2 mL	208 EUR
NATtrol EV Negative Control (6 X 0.5 mL)
MDZ056	Zeptometrix	6 X 0.2 mL	208 EUR
NATtrol SA Positive Control (6 X 0.5 mL)
MDZ061	Zeptometrix	6 X 0.5 mL	378.24 EUR
Recombinant (E. coli) Purified Pasteurella multocida toxin (PMT) control for western blot
PMT11-C	Alpha Diagnostics	100 ul	343.2 EUR
NATtrol MRSA Positive Control (6 x 0.35mL)
NATMRSA-6L	Zeptometrix	6 x 0.35mL	277 EUR
Rat neurofascin (Nfasc)-control Control/blocking peptide
AB-23249-CP	Alpha Diagnostics	100ug	196.8 EUR
AS Control
A26	DataApex	-	330 EUR
GC Control
A23	DataApex	-	600 EUR
LC Control
A24	DataApex	-	600 EUR
NATtrol GBS Negative Control (6 X 0.5 mL)
NATLAC-6MC	Zeptometrix	6 X 0.5 mL	313 EUR
NATtrol GBS Negative Control (6 X 0.5 mL)
NATLAC-6MC-IVD	Zeptometrix	6 X 0.5 mL	333 EUR
NATtrol RSV Positive Control (6 X 0.5 mL)
NATRSV-6C-IVD	Zeptometrix	6 X 0.5 mL	242 EUR
NATtrol GBS Positive Control (6 x 0.25 mL)
NATSAG-6L	Zeptometrix	6 x 0.25 mL	272 EUR
NATtrol GBS Positive Control (6 X 0.5 mL)
NATSAG-6MC	Zeptometrix	6 X 0.5 mL	313 EUR
NATtrol GBS Positive Control (6 x 0.5 mL)
NATSAG-6MC-IVD	Zeptometrix	6 x 0.5 mL	333 EUR
NATtrol RSV Positive Control (6 X 0.5 mL)
MDZ047	Zeptometrix	6 X 0.5 mL	278.4 EUR
NATtrol GBS Positive Control (6 x 0.5 mL)
MDZ053	Zeptometrix	6 x 0.5 mL	378.24 EUR
NATtrol GBS Negative Control (6 X 0.5 mL)
MDZ054	Zeptometrix	6 X 0.5 mL	378.24 EUR
NATtrol EP Control (12 x 0.25 mL; 2 x 1mL)
NATEPC-NNS	Zeptometrix	12 x 0.25 mL; 2 x 1mL	452 EUR
Rat Control
DEV99RC	Demeditec Diagnostics	2 x 1 ml	60 EUR
MDP control
tlrl-mdpcl	InvivoGen FR	5 mg	148.05 EUR
NATtrol MRSA Positive Control (6 X 0.5 mL)
NATMRSA-6MC	Zeptometrix	6 X 0.5 mL	315 EUR
NATtrol MRSA Positive Control  (6 X 0.5 mL)
NATMRSA-6MC-IVD	Zeptometrix	6 X 0.5 mL	335 EUR
NATtrol MRSA Positive Control (6 X 0.5 mL)
MDZ059	Zeptometrix	6 X 0.5 mL	378.24 EUR
BMP4 Control
MBS542571-5Applications	MyBiosource	5Applications	335 EUR
BMP4 Control
MBS542571-5x5Applications	MyBiosource	5x5Applications	1350 EUR
Rat IgG-PE conjugate (isotype control) (Isotype control)
20005-PE	Alpha Diagnostics	25 tests	242.4 EUR
NATtrol Norovirus GI/GII Positive Control (6 x 0.125mL)
NATNOV-6MC	Zeptometrix	6 x 0.125mL	205 EUR
Rat IgG-HRP conjugate (isotype control) (Isotype control)
20005-HP	Alpha Diagnostics	100 ug	196.8 EUR
NPY1R Control
MBS543000-5Applications	MyBiosource	5Applications	335 EUR
ADCY3 Control
MBS543023-5Applications	MyBiosource	5Applications	335 EUR
ADCY3 Control
MBS543023-5x5Applications	MyBiosource	5x5Applications	1350 EUR
NPY1R Control
MBS543000-5x5Applications	MyBiosource	5x5Applications	1350 EUR
pGIPZ control
PVTY00348	Nova Lifetech	2ug	280 EUR
pMD19- Control
PVT10564	Nova Lifetech	2ug	182 EUR
Rat IgG-FITC conjugate (isotype control) (Isotype control)
20005-F	Alpha Diagnostics	100 ug	196.8 EUR
NATtrol CT/NG Negative Control (6 X 1 mL)
NATCT/NGNEG-6MC	Zeptometrix	6 X 1 mL	220 EUR
Control Slides
24012-1	Polysciences Europe GmbH	1box	78 EUR
Canine Control
DEV99CC	Demeditec Diagnostics	2 x 1 ml	60 EUR
Dengue Control
ant-543	ProSpec Tany	100µg	165 EUR
Canine Control
MBS495203-1Set	MyBiosource	1Set	305 EUR
Canine Control
MBS495203-5x1Set	MyBiosource	5x1Set	1390 EUR
pTRIPZ control
PVTY00369	Nova Lifetech	2ug	280 EUR
NATtrol Strep A Negative Control (6 x 0.5mL)
NATSDG-6MC	Zeptometrix	6 x 0.5mL	221 EUR
NATtrol Strep A Positive Control (6 x 0.5mL)
NATSPY-6MC	Zeptometrix	6 x 0.5mL	221 EUR
Rat IgG-Biotin conjugate (isotype control) (Isotype control)
20005-B	Alpha Diagnostics	100 ug	196.8 EUR
NATtrol CT/NG/TV Negative Control (6 x 1.0mL)
NATCTNGTV-NEG	Zeptometrix	6 x 1.0mL	97 EUR
NATtrol CT/NG/TV Positive Control (6 x 1.0mL)
NATCTNGTV-POS	Zeptometrix	6 x 1.0mL	368 EUR
Lectin binding native protein (positive control)
LBP18-N-1	Alpha Diagnostics	1 ml	270 EUR
Quality Control
abx098966-1vial	Abbexa	1 vial	360 EUR
Ascites, Control
MBS652640-10mL	MyBiosource	10mL	415 EUR
Ascites, Control
MBS652640-1mL	MyBiosource	1mL	190 EUR
Ascites, Control
MBS652640-5x10mL	MyBiosource	5x10mL	1710 EUR
Goat IgG (-ve control for flow cytometry) (isotype control)
20011-100	Alpha Diagnostics	100 test	123.6 EUR
Human IgD, Human Native Plasma (isotype control)
20007-8P-25	Alpha Diagnostics	25 ug	343.2 EUR
Control for Tyrosinase, 4 cases (1.5mm)HumanskinSkinIHC control
TYROSIN081	Pantomics	1.5mm	50 EUR
Negative Control
MBS2568128-1mL	MyBiosource	1mL	140 EUR
Negative Control
MBS2568129-1mL	MyBiosource	1mL	135 EUR
Positive Control
MBS2568130-1mL	MyBiosource	1mL	150 EUR
Positive Control
MBS2568131-1mL	MyBiosource	1mL	150 EUR
NATtrol MRSA/SA Negative Control (6 X 0.5 mL)
NATMSSE-6MC	Zeptometrix	6 X 0.5 mL	307 EUR
NATtrol MRSA/SA Negative Control (6 X 0.5 mL)
NATMSSE-6MC-IVD	Zeptometrix	6 X 0.5 mL	327 EUR
NATtrol MRSA/SA Negative Control (6 X 0.5 mL)
MDZ060	Zeptometrix	6 X 0.5 mL	378.24 EUR
PIPET CONTROLLER CONTROL BOARD
357484	CORNING	1/pk	104.4 EUR
Control siRNA Vector (pGB-control)
9500C-20	Biovision	each	405.6 EUR
Mouse Parvovirus Native Antigen Positive Control
MBS412084-1mL	MyBiosource	1mL	175 EUR
Mouse Parvovirus Native Antigen Positive Control
MBS412084-5x1mL	MyBiosource	5x1mL	645 EUR
OOSA10387-100T - IgM NEGATIVE CONTROL Negative/Isotype Control
OOSA10387-100T	Aviva Systems Biology	100Tests	309 EUR
OOSA10342-100UG - IgG1 NEGATIVE CONTROL Negative/Isotype Control
OOSA10342-100UG	Aviva Systems Biology	0.1mg	219 EUR
OOSA10349-100T - IgG2a NEGATIVE CONTROL Negative/Isotype Control
OOSA10349-100T	Aviva Systems Biology	100Tests	299 EUR
OOSA10380-100T - IgG2b NEGATIVE CONTROL Negative/Isotype Control
OOSA10380-100T	Aviva Systems Biology	100Tests	309 EUR
OOSA10389-100T - IgG1 NEGATIVE CONTROL Negative/Isotype Control
OOSA10389-100T	Aviva Systems Biology	100Tests	309 EUR
OOSA10397-100T - IgG2a NEGATIVE CONTROL Negative/Isotype Control
OOSA10397-100T	Aviva Systems Biology	100Tests	309 EUR
NATtrol Influenza Negative Control (6 X 0.5 mL)
NATCXVA9-6MC	Zeptometrix	6 X 0.5 mL	220 EUR
NATtrol Norovirus Negative Control (6 X 0.5 mL)
NATROTA-6MC-IVD	Zeptometrix	6 X 0.5 mL	223 EUR
NATtrol T.vaginalis Negative Control (6 x 1.2 mL)
NATTVNEG-6MC	Zeptometrix	6 x 1.2 mL	348 EUR
NATtrol T.vaginalis Positive Control (6 x 1.2 mL)
NATTVPOS-6MC	Zeptometrix	6 x 1.2 mL	348 EUR
NATtrol Norovirus Negative Control (6 X 0.5 mL)
MDZ052	Zeptometrix	6 X 0.5 mL	255.94 EUR
CypExpress Control
MBS480553-10g	MyBiosource	10g	1905 EUR
CypExpress Control
MBS480553-1g	MyBiosource	1g	320 EUR
CypExpress Control
MBS480553-5x10g	MyBiosource	5x10g	8355 EUR
CypExpress Control
MBS480553-5x1g	MyBiosource	5x1g	1220 EUR
ODN 2088 control
tlrl-2088c-1	InvivoGen FR	1 mg	546 EUR
ODN 2395 control
tlrl-2395c-1	InvivoGen FR	1 mg	546 EUR
Control for Mammaglobin, 4 cases (1.5mm)HumanBreastBreastIHC control
MAMA-G081	Pantomics	1.5mm	50 EUR
NATtrol HSV 1 & 2 Positive Control (6 x 0.25 mL)
NATHSV-6L	Zeptometrix	6 x 0.25 mL	272 EUR
Human IgE (Native, Plasma), purified (isotype control)
20007-3P	Alpha Diagnostics	50 ug	489.6 EUR
Human IgA purified (native, Plasma) (isotype control)
20007-5-1	Alpha Diagnostics	1 mg	196.8 EUR
Human IgA purified (native, Plasma) (isotype control)
20007-5-5	Alpha Diagnostics	5 mg	708 EUR
SERION ELISA Avidity control Rubella Virus Avidity Control IgG
MBS191655-INQUIRE	MyBiosource	INQUIRE	Ask for price
NATtrol CT/NG Negative Control Pack (6 X 1.25 mL)
NATCT/NGNEG-6MC-IVD	Zeptometrix	6 X 1.25 mL	240 EUR
NATtrol CT/NG Negative Control Pack (6 X 1.25 mL)
MDZ004	Zeptometrix	6 X 1.25 mL	299.62 EUR
Control FD BNP
K023M-6	Audit MicroControls	6 x 1 mL	292 EUR
Control FD TDM
K068M-6	Audit MicroControls	6 x 5 mL	205 EUR
NATtrol Influenza/RSV Negative Control (6 x 0.5mL)
NATCXVA9-6C	Zeptometrix	6 x 0.5mL	220 EUR
Control for GCDFP-15, 4 cases (1.5mm)HumanBreastBreastIHC control
GCDFP081	Pantomics	1.5mm	50 EUR
EDG-1 Control
BC-009	Kamiya Biomedical Company	100 uL	350 EUR
EDG-2 Control
BC-011	Kamiya Biomedical Company	100 uL	350 EUR
EDG-4 Control
BC-012	Kamiya Biomedical Company	100 uL	350 EUR
EDG-6 Control
BC-014	Kamiya Biomedical Company	100 uL	350 EUR
EDG-7 Control
BC-016	Kamiya Biomedical Company	100 uL	350 EUR
Rat Control IgG
AC034	Abclonal	100 ul	159.6 EUR
β-Gal Control
LV007	ABM	4 x 500 ul	195 EUR
NF-κB Control
T37559-10mg	TargetMol Chemicals	10mg	Ask for price
NF-κB Control
T37559-1g	TargetMol Chemicals	1g	Ask for price
NF-κB Control
T37559-1mg	TargetMol Chemicals	1mg	Ask for price
NF-κB Control
T37559-50mg	TargetMol Chemicals	50mg	Ask for price
NF-κB Control
T37559-5mg	TargetMol Chemicals	5mg	Ask for price
Rat Control IgG
MBS9144358-01mL	MyBiosource	0.1mL	140 EUR
Rat Control IgG
MBS9144358-5x01mL	MyBiosource	5x0.1mL	465 EUR
Rat Parvovirus (RPV), Native Antigen Positive Control
MBS412082-1mL	MyBiosource	1mL	175 EUR
Rat Parvovirus (RPV), Native Antigen Positive Control
MBS412082-5x1mL	MyBiosource	5x1mL	645 EUR
NATtrol Influenza/RSV Positive Control (6 x 0.25mL)
NATFLURSV-6L	Zeptometrix	6 x 0.25mL	272 EUR
OOSA10361-1ML - Rat IgG2a NEGATIVE CONTROL Negative/Isotype Control
OOSA10361-1ML	Aviva Systems Biology	1ml	169 EUR
SERION ELISA Avidity control Toxoplasma gondii Avidity Control IgG
MBS191654-INQUIRE	MyBiosource	INQUIRE	Ask for price
Control for MSH2, 4 cases (1.5mm)HumanDigestive systemColonIHC control
MSH2081	Pantomics	1.5mm	50 EUR
Control for Olig2, 4 cases (1.5mm)HumanNervous systemBrainIHC control
OLIG2081	Pantomics	1.5mm	50 EUR

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Tuttavia, lo studio di associazione pianificato sull’ampio genoma dei fenotipi di risposta e l’inclusione dei dati individuali di fenotipo e genotipo da questo studio nelle meta-analisi promettono di identificare in definitiva vulnerabilità e varianti protettive.