Scopo: descrivere la prima serie di sei pazienti giovani con melanoma uveale (UM) con isotretinoina orale e / o terapia topica con retinoidi prima della diagnosi.
Osservazioni: la serie di casi si basa su osservazioni cliniche presso il nostro centro di riferimento quaternario UM. Vengono segnalati sei casi di pazienti UM, di età compresa tra 16 e 44 anni. Tutti avevano usato un trattamento con retinoidi orale (isotretinoina) e / o topico (tretinoina o tazarotene) (3 mesi- ~ 10 anni) prima o al momento della diagnosi (3 su 6 casi). Tutti i pazienti presentavano disturbi oculari e l’insorgenza di alcuni sintomi corrispondeva al decorso dei retinoidi. Altri potenziali fattori di rischio o anamnesi rilevante includevano sfondo caucasico, distrofia conica e stato di fumatore attivo (caso 2), storia familiare di UM e gravidanza al momento della diagnosi (caso 3), fumo passato e possibile esposizione secondaria a Chernobyl da bambino ( Caso 5). Tutti i pazienti sono stati trattati con radioterapia a fascio di protoni e attualmente non hanno segni di malattia recidivante o metastatica.
Conclusioni e importanza: la terapia con retinoidi è stata collegata a vari effetti benigni e / o reversibili sull’occhio anteriore e posteriore, sebbene la fisiopatologia non sia ancora ben compresa. Il melanoma uveale (UM) è una rara diagnosi di cancro nei giovani adulti. Riportiamo qui la prima serie di casi di giovani pazienti di UM con una storia di uso di retinoidi e disturbi oculari. Non viene affermato alcun nesso causale e ulteriori studi epidemiologici e biologici sistematici sulla terapia con retinoidi e sull’impatto oculare possono fornire ulteriori dati rilevanti, in particolare nei pazienti giovani con melanoma oculare.
Aggiornamento teratogeno: uso topico e retinoidi di terza generazione
I primi retinoidi farmaceutici approvati dalla Food and Drug Administration degli Stati Uniti hanno ricevuto avvertimenti da scatola nera contro il loro uso in gravidanza a causa di potenziali effetti teratogeni. Questi retinoidi di prima e seconda generazione sono stati inizialmente formulati per il dosaggio orale e sono strutturalmente molto simili alla vitamina A, che ha effetti benefici sulla pelle e svolge un ruolo fondamentale nel guidare l’embriogenesi sana. Da allora, alcuni di questi retinoidi precoci sono stati riformulati per l’applicazione topica, il che ha ridotto il loro potenziale di esposizione sistemica. Inoltre, la progettazione razionale dei farmaci è stata applicata per creare i retinoidi di terza generazione di oggi (adapalene, tazarotene e bexarotene).
Questi composti includono anelli aromatici all’interno dei loro nuclei molecolari per fornire una rigidità strutturale che contrasta con la spina dorsale alifatica flessibile della vitamina A e delle precedenti generazioni di retinoidi, e quindi limita la loro attività fuori bersaglio. Come risultato di queste caratteristiche progettuali, il potenziale teratogeno negli animali dei retinoidi di terza generazione e in quelli riformulati per uso topico è generalmente inferiore a quello osservato con la somministrazione orale di generazioni precedenti di retinoidi. I dati epidemiologici disponibili, ma limitati, mostrano inoltre un potenziale teratogeno minimo o nullo associato all’uso nella vita reale di questi composti nell’uomo. Data la scarsità di dati epidemiologici disponibili in questo momento, tuttavia, si raccomanda di evitare l’uso di retinoidi topici durante la gravidanza. Tuttavia, in circostanze in cui può verificarsi un’esposizione involontaria in gravidanza, i dati disponibili forniscono una certa rassicurazione sul fatto che gli esiti avversi della gravidanza sono improbabili.
Chemerin come un driver di ipertensione: una considerazione
La proteina chemerina (gene indotto dal tazarotene, TIG2; RARRES2) è un’adipochina relativamente nuova. Molti studi supportano che i livelli di chemerina circolanti si associano fortemente e positivamente con BMI, grasso viscerale e pressione sanguigna. Qui, ci concentriamo sulla relazione specifica tra chemerina e pressione sanguigna con l’obiettivo di capire se e come la chemerina guida i cambiamenti (patologici) della pressione sanguigna in modo tale da poter essere interferiti terapeuticamente. Analizziamo la biosintesi della chemerina e come gli attuali farmaci antipertensivi modificano il metabolismo delle chemerine. Segue una rassegna di ciò che è noto su dove la chemerina è sintetizzata nel corpo e cosa possono fare la chemerina ei suoi recettori per la funzione fisiologica degli organi importanti per la determinazione della pressione sanguigna (ad es. Cervello, cuore, reni, vasi sanguigni, surrene e sistema nervoso simpatico).
Sintetizziamo dalla letteratura la nostra migliore comprensione dei meccanismi con cui la chemerina modifica la pressione sanguigna, con la consapevolezza che i livelli plasmatici / sierici di chemerina possono essere limitati nella loro rilevanza patologica. Questa revisione rivela diverse lacune nella nostra conoscenza della biologia delle chemerine che potrebbero essere colmate dal lavoro collettivo di chimici delle proteine, biologi, farmacologi e medici. Il tazarotene è un profarmaco che appartiene alla classe acetilenica dei retinoidi. Il farmaco è stato sottoposto a stress test idrolitico, ossidativo e fotolitico per stabilire la sua chimica di degradazione completa. Il farmaco si è dimostrato instabile in condizioni idrolitiche acide e basiche, producendo acido tazarotenico, che è un noto prodotto di degradazione principale (DP) e un metabolita attivo.
Soft Tissue Tissue Slide (Skeletal Muscle-Benign) |
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12-343-10um | ProSci | 10 um | 241.8 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-Benign) |
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12-343-4um | ProSci | 4 um | 216.6 EUR |
Rat Skeletal Muscle Tissue Lysate |
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IRTSKMTL100UG | Innovative research | each | 245 EUR |
Description: Rat Skeletal Muscle Tissue Lysate |
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Rat Skeletal Muscle Tissue Lysate |
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LYSATE0010 | BosterBio | 200ug | 180 EUR |
Description: This cell lysate is prepared from rat skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C. |
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Human Skeletal Muscle Tissue Lysate |
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IHUSKMTL100UG | Innovative research | each | 245 EUR |
Description: Human Skeletal Muscle Tissue Lysate |
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Mouse Skeletal Muscle Tissue Lysate |
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IMSSKMTL100UG | Innovative research | each | 245 EUR |
Description: Mouse Skeletal Muscle Tissue Lysate |
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Mouse Skeletal Muscle Tissue Lysate |
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LYSATE0021 | BosterBio | 200ug | 180 EUR |
Description: This cell lysate is prepared from mouse skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C. |
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Soft Tissue Tissue Slide (Skeletal Muscle-malignant) |
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12-345-10um | ProSci | 10 um | 241.8 EUR |
Soft Tissue Tissue Slide (Skeletal Muscle-malignant) |
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12-345-4um | ProSci | 4 um | 216.6 EUR |
Bovine Skeletal Muscle Tissue Lysate |
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IBOSKMTL100UG | Innovative research | each | 541 EUR |
Description: Bovine Skeletal Muscle Tissue Lysate |
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41225-2 RB MUSCLE TISSUE YG (1-kg) |
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41225-2 | Pel-Freez | 1 kg | 225 EUR |
41325-2 RB MUSCLE TISSUE MT FROZEN 1kg |
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41325-2 | Pel-Freez | 1 kg | 225 EUR |
Rat Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells |
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9-80281 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Diabetes Skeletal Muscle Tissue Lysate |
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IHUSKMDIBTL100UG | Innovative research | each | 1413 EUR |
Description: Human Diabetes Skeletal Muscle Tissue Lysate |
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Smooth muscle and striated muscle disease spectrum tissue array |
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SO8011 | TissueArray | each | 414 EUR |
Description: Smooth muscle and striated muscle disease spectrum tissue array, including TNM and clinical stage, 80 cases /80 cores |
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Human Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells |
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9-80092 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells |
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9-80189 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells |
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9-80280 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells |
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9-80091 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells |
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9-80188 | CHI Scientific | 1 x 100 ml | Ask for price |
Monkey Cynomolgus Skeletal Muscle Tissue Lysate |
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IMNCYSKMTL100UG | Innovative research | each | 541 EUR |
Description: Monkey Cynomolgus Skeletal Muscle Tissue Lysate |
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cDNA - Dog Normal Tissue: Skeletal Muscle |
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C1734171 | Biochain | 40 reactions | 424 EUR |
cDNA - Rat Normal Tissue: Skeletal Muscle |
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C1434171 | Biochain | 40 reactions | 424 EUR |
Rhabdomyosarcoma with striated muscle tissue array |
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SO2082b | TissueArray | each | 546 EUR |
Description: Rhabdomyosarcoma with striated muscle tissue array, including TNM and clinical stage, 104 cases/208 cores, replacing SO2082a |
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cDNA - Human Tumor Tissue: Skeletal Muscle |
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C1235171-10 | Biochain | 10 reactions | 301 EUR |
Rat Skeletal Muscle Whole tissue lysate |
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RAL-1467 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Skeletal Muscle |
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T1236171Dia | Biochain | 5 slides | 523 EUR |
Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array |
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SO2081 | TissueArray | each | 474 EUR |
Description: Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array, 104 cases/208 cores |
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cDNA - Mouse Normal Tissue: Skeletal Muscle |
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C1334171 | Biochain | 40 reactions | 424 EUR |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Skeletal Muscle |
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T2236171Dia | Biochain | 5 slides | 262 EUR |
Human Skeletal Muscle Fetal Tissue Lysate |
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IHUSKMFSTL100UG | Innovative research | each | 541 EUR |
Description: Human Skeletal Muscle Fetal Tissue Lysate |
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Mouse Skeletal Muscle Whole tissue lysate |
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MAL-1407 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Rat Muscle OptiTDS1: Tissue Dissociation System |
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4-28280 | CHI Scientific | 1 Kit | Ask for price |
Rat Muscle OptiTDS2: Tissue Dissociation System |
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4-28281 | CHI Scientific | 1 Kit | Ask for price |
Total RNA - Rat Normal Tissue: Skeletal Muscle |
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R1434171-50 | Biochain | 50 ug | 156 EUR |
Human Muscle OptiTDS1: Tissue Dissociation System |
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4-28091 | CHI Scientific | 1 Kit | Ask for price |
Human Muscle OptiTDS2: Tissue Dissociation System |
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4-28092 | CHI Scientific | 1 Kit | Ask for price |
Mouse Muscle OptiTDS1: Tissue Dissociation System |
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4-28188 | CHI Scientific | 1 Kit | Ask for price |
Mouse Muscle OptiTDS2: Tissue Dissociation System |
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4-28189 | CHI Scientific | 1 Kit | Ask for price |
Genomic DNA - Rat Normal Tissue: Skeletal Muscle |
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D1434171 | Biochain | 100 ug | 329 EUR |
Total RNA - Mouse Normal Tissue: Skeletal Muscle |
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R1334171-50 | Biochain | 50 ug | 156 EUR |
cDNA - Human Adult Normal Tissue: Skeletal Muscle |
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C1234171 | Biochain | 40 reactions | 424 EUR |
Rabbit SUBMAXILLARY MATURE 50 EA |
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41343-2 | Pel-Freez | 50 EA | 382.07 EUR |
Genomic DNA - Mouse Normal Tissue: Skeletal Muscle |
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D1334171 | Biochain | 100 ug | 329 EUR |
cDNA - Monkey (Rhesus) Normal Tissue: Skeletal Muscle |
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C1534171 | Biochain | 40 reactions | 481 EUR |
Total Protein - Human Tumor Tissue: Skeletal Muscle |
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P1235171 | Biochain | 1 mg | 357 EUR |
Total Protein - Mouse Normal Tissue: Skeletal Muscle |
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P1334171 | Biochain | 1 mg | 216 EUR |
cDNA - Human Diabetic Diseased Tissue: Skeletal Muscle |
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C1236171Dia | Biochain | 40 reactions | 802 EUR |
cDNA - Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle |
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C1534171-Cy | Biochain | 40 reactions | 481 EUR |
Human Liver Cirrhosis Muscle Diaphragm Tissue Lysate |
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IHUMSCDPHCIRTL100UG | Innovative research | each | 1413 EUR |
Description: Human Liver Cirrhosis Muscle Diaphragm Tissue Lysate |
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Total RNA - Human Adult Normal Tissue: Skeletal Muscle |
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R1234171-50 | Biochain | 50 ug | 221 EUR |
Total RNA - Human Adult Normal Tissue: Muscle: Diaphragm |
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R1234169-10 | Biochain | 10 ug | 221 EUR |
Total RNA - Monkey (Rhesus) Normal Tissue: Skeletal Muscle |
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R1534171-50 | Biochain | 50 ug | 229 EUR |
Human Adult Skeletal Muscle (Normal) Whole tissue lysate |
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HAL-1375 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Monkey (Cyno.) Normal Skeletal Muscle Whole tissue lysate |
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MCL-1197 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Total Protein - Human Adult Normal Tissue: Skeletal Muscle |
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P1234171 | Biochain | 1 mg | 216 EUR |
Monkey (Rhesus) Normal Skeletal Muscle Whole tissue lysate |
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MRL-1247 | Alpha Diagnostics | 1 mg | 628.8 EUR |
Frozen Tissue Section - Human Adult Normal: Skeletal Muscle |
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T1234171 | Biochain | 5 slides | 377 EUR |
Total RNA - Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle |
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R1534171-Cy | Biochain | 50 ug | 229 EUR |
Membrane Protein - Human Adult Normal Tissue: Skeletal Muscle |
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P3234171 | Biochain | 0.1 mg | 311 EUR |
Paraffin Tissue Section - Human Adult Normal: Skeletal Muscle |
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T2234171 | Biochain | 5 slides | 204 EUR |
Total RNA - Human Adult Normal Tissue: Heart: Papilla Muscle |
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R1234132-10 | Biochain | 10 ug | 221 EUR |
Total Protein - Human Diabetic Diseased Tissue: Skeletal Muscle |
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P1236171Dia | Biochain | 1 mg | 542 EUR |
Total Protein - Human Adult Normal Tissue: Heart: Papilla Muscle |
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P1234132 | Biochain | 1 mg | 590 EUR |
Human Soft Tissue Slide (Skeletal Muscle Normal) (5 slides/pk) |
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HTS-12341 | Alpha Diagnostics | 1 pk | 343.2 EUR |
Human Soft Tissue Slide (Skeletal Muscle Benign) (5 slides/pk) |
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HTS-12343 | Alpha Diagnostics | 1 pk | 343.2 EUR |
Skeletal Muscle Tissue Slides, Normal Rat Paraffin Sections, 5 slides/pack |
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TS-R5410 | IHC World | - | 145 EUR |
Paraffin Tissue Section - Human Adult Normal: Heart: Papilla Muscle |
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T2234132 | Biochain | 5 slides | 204 EUR |
Human Soft Tissue Slide (Skeletal Muscle Malignant) (5 slides/pk) |
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HTS-12345 | Alpha Diagnostics | 1 pk | 343.2 EUR |
Skeletal Muscle Tissue Slides, Normal Human Paraffin Sections, 5 slides/pack |
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TS-H5019 | IHC World | - | 145 EUR |
Skeletal Muscle Tissue Slides, Normal Mouse Paraffin Sections, 5 slides/pack |
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TS-M5208 | IHC World | - | 145 EUR |
Total RNA - Human Adult Normal Tissue 5 Donor Pool: Skeletal Muscle |
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R1234171-P | Biochain | 50 ug | 443 EUR |
Rat Bladder Tissue Preparation Buffer 3: Normal Smooth Muscle Cells |
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9-80215 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells |
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9-80288 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells |
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9-80100 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells |
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9-80198 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Heart Tissue Preparation Buffer 1: Normal Aortic Smooth Muscle Cells |
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9-80253 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Heart Tissue Preparation Buffer 1: Normal Aortic Smooth Muscle Cells |
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9-80066 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Heart Tissue Preparation Buffer 1: Normal Aortic Smooth Muscle Cells |
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9-80159 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Cervix Tissue Preparation Buffer 3: Normal Cervical Smooth Muscle Cells |
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9-80233 | CHI Scientific | 1 x 100 ml | Ask for price |
Genomic DNA - Human Adult Normal Tissue: Skeletal Muscle, from a single donor |
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D1234171 | Biochain | 100 ug | 329 EUR |
Human Bladder Tissue Preparation Buffer 3: Normal Bladder Smooth Muscle Cells |
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9-80009 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Cervix Tissue Preparation Buffer 3: Normal Cervical Smooth Muscle Cells |
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9-80046 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Cervix Tissue Preparation Buffer 3: Normal Cervical Smooth Muscle Cells |
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9-80139 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Colon Tissue Preparation Buffer 2: Normal Colorectal Smooth Muscle Cells |
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9-80237 | CHI Scientific | 1 x 100 ml | Ask for price |
cpl-1 (Mature-region) rabbit polyclonal antibody, Purified |
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AP54829PU-N | Origene Technologies GmbH | 100 µg | Ask for price |
Rat Esophagus Tissue Preparation Buffer 2: Normal Esophageal Smooth Muscle Cells |
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9-80244 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Intestine Tissue Preparation Buffer 2: Normal Intestinal Smooth Muscle Cells |
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9-80260 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Lung Tissue Preparation Buffer 6: Normal Pulmonary Vein Smooth Muscle Cells |
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9-80276 | CHI Scientific | 1 x 100 ml | Ask for price |
Genomic DNA - Human Diabetic Diseased Tissue: Skeletal Muscle, from a single donor |
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D1236171Dia | Biochain | 50 ug | 562 EUR |
Minute TM Mitochondria Isolation Kit for Muscle Tissues/Cultured Muscle Cells (50 Tests) |
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MM-038 | Inventbiotech | each | 535 EUR |
Human Esophagus Tissue Preparation Buffer 2: Normal Esophageal Smooth Muscle Cells |
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9-80056 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Intestine Tissue Preparation Buffer 2: Normal Intestinal Smooth Muscle Cells |
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9-80072 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Esophagus Tissue Preparation Buffer 2: Normal Esophageal Smooth Muscle Cells |
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9-80150 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Intestine Tissue Preparation Buffer 4: Normal Intestinal Smooth Muscle Cells |
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9-80168 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Lung Tissue Preparation Buffer 6: Normal Pulmonary Vein Smooth Muscle Cells |
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9-80086 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Lung Tissue Preparation Buffer 7: Normal Pulmonary Vein Smooth Muscle Cells |
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9-80184 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Lung Tissue Preparation Buffer 4: Normal Pulmonary Artery Smooth Muscle Cells |
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9-80274 | CHI Scientific | 1 x 100 ml | Ask for price |
Actin, Rabbit Muscle |
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P1246-1000 | Biovision | each | 274.8 EUR |
Actin, Rabbit Muscle |
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P1246-500 | Biovision | each | 196.8 EUR |
Human Lung Tissue Preparation Buffer 4: Normal Pulmonary Artery Smooth Muscle Cells |
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9-80084 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Lung Tissue Preparation Buffer 5: Normal Pulmonary Artery Smooth Muscle Cells |
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9-80182 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Umbilical Cord Tissue Preparation Buffer: Normal Umbilical Vein Smooth Muscle Cells |
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9-80294 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Umbilical Cord Tissue Preparation Buffer: Normal Umbilical Vein Smooth Muscle Cells |
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9-80205 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Airway Tissue Preparation Buffer 2: Normal Bronchial and Tracheal Smooth Muscle Cells |
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9-80209 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Airway Tissue Preparation Buffer 3: Normal Bronchial and Tracheal Smooth Muscle Cells |
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9-80003 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Umbilical Cord Tissue Preparation Buffer 5: Normal Umbilical Vein Smooth Muscle Cells |
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9-80110 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Airway Tissue Preparation Buffer 2: Normal Bronchial and Tracheal Smooth Muscle Cells |
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9-80116 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Brain Tissue Preparation Buffer 11: Normal Cerebral Artery Vascular Smooth Muscle Cells |
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9-80220 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Brain Tissue Preparation Buffer 5: Normal Cerebral Venous Vascular Smooth Muscle Cells |
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9-80223 | CHI Scientific | 1 x 100 ml | Ask for price |
Actin Protein (MICAL-Oxidized): Rabbit Skeletal Muscle (Rabbit Muscle, > 95% Pure ) |
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MXA95 | Cytoskeleton | 2 x 250 µg | 362.96 EUR |
Actin Protein (MICAL-Oxidized): Rabbit Skeletal Muscle (Rabbit Muscle, > 95% Pure ) |
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MXA95-XL | Cytoskeleton | 1 x 1 mg | 590.72 EUR |
Human Brain Tissue Preparation Buffer 3: Normal Cerebral Artery Vascular Smooth Muscle Cells |
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9-80015 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Brain Tissue Preparation Buffer 6: Normal Cerebral Venous Vascular Smooth Muscle Cells |
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9-80018 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Umbilical Cord Tissue Preparation Buffer 2: Normal Umbilical Artery Smooth Muscle Cells |
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9-80107 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Brain Tissue Preparation Buffer 3: Normal Cerebral Artery Vascular Smooth Muscle Cells |
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9-80126 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Brain Tissue Preparation Buffer 6: Normal Cerebral Venous Vascular Smooth Muscle Cells |
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9-80129 | CHI Scientific | 1 x 100 ml | Ask for price |
Rabbit Anti Human Carboxypeptidase H (Mature N-Terminal) Polyclonal Antibody |
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CPBT-66584RH | Creative Diagnostics | 0.1 ml | 920.4 EUR |
Aldolase (Rabbit Muscle) Antibody |
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abx022821-50mg | Abbexa | 50 mg | 1262.4 EUR |
Aldolase Antibody (Rabbit Muscle) |
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GWB-153D38 | GenWay Biotech | 50 mg | Ask for price |
Purified (>95%) muscle Actin Protein from muscle (rabbit/bovine) |
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ACTB15-N-1 | Alpha Diagnostics | 1 mg | 489.6 EUR |
Rabbit Skeletal Muscle Cells |
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CP-Rb013 | Elabscience Biotech | 5×105 cells/vial | 610 EUR |
Description: Rabbit |
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Pyrene Labeled Actin Protein (MICAL-Oxidized): Rabbit Skeletal Muscle (Rabbit Muscle, > 95% Pure ) |
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MPAX1 | Cytoskeleton | 2 x 250 µg | 422.24 EUR |
Pyrene Labeled Actin Protein (MICAL-Oxidized): Rabbit Skeletal Muscle (Rabbit Muscle, > 95% Pure ) |
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MPAX1-XL | Cytoskeleton | 1 x 1 mg | 679.12 EUR |
Tissue Factor Rabbit mAb |
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59064 | SAB | 100ul | 339 EUR |
Tissue Factor Rabbit mAb |
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52668 | SAB | 100ul | 499 EUR |
Tissue Factor Rabbit pAb |
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E2381361 | EnoGene | 100ul | 225 EUR |
Description: Available in various conjugation types. |
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Tissue Factor Rabbit mAb |
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E2R26161 | EnoGene | 100ul | 255 EUR |
Description: Available in various conjugation types. |
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Tissue Factor Rabbit mAb |
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E2R27360 | EnoGene | 100ul | 255 EUR |
Description: Available in various conjugation types. |
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Tissue Factor Rabbit mAb |
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E2R27361 | EnoGene | 100ul | 255 EUR |
Description: Available in various conjugation types. |
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Tissue Factor Rabbit mAb |
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A4395-100ul | Abclonal | 100 ul | 492 EUR |
Tissue Factor Rabbit mAb |
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A4395-200ul | Abclonal | 200 ul | 685.2 EUR |
Tissue Factor Rabbit mAb |
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A4395-20ul | Abclonal | 20 ul | 265.2 EUR |
Tissue Factor Rabbit mAb |
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A4395-50ul | Abclonal | 50 ul | 344.4 EUR |
Tissue Factor Rabbit mAb |
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E2R381361 | EnoGene | 100ul | 275 EUR |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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Rabbit Polyclonal antibody to PFK (muscle) (phosphofructokinase, muscle) |
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TA308655 | Origene Technologies GmbH | 100 µl | Ask for price |
Rabbit Tissue Transglutaminase |
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E01A34660 | BlueGene | 96T | 700 EUR |
Description: ELISA |
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Rabbit Lung Tissue Lysate |
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IRBLGTL100UG | Innovative research | each | 541 EUR |
Description: Rabbit Lung Tissue Lysate |
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Actin, pyrene labeled, Rabbit Muscle |
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M1319-1000 | Biovision | each | 222 EUR |
Actin, pyrene labeled, Rabbit Muscle |
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M1319-500 | Biovision | each | 183.6 EUR |
Rabbit Liver Tissue Lysate |
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30R-AL003 | Fitzgerald | 150 ug | 206 EUR |
Description: Fresh tissue lysate prepared from rabbit liver |
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Rabbit Brain Tissue Lysate |
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IRBBRTL100UG | Innovative research | each | 541 EUR |
Description: Rabbit Brain Tissue Lysate |
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Rabbit Heart Tissue Lysate |
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IRBHTTL100UG | Innovative research | each | 541 EUR |
Description: Rabbit Heart Tissue Lysate |
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Rabbit Liver Tissue Lysate |
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IRBLRTL100UG | Innovative research | each | 541 EUR |
Description: Rabbit Liver Tissue Lysate |
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Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I |
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T6834700-G01-1 | Biochain | 1 slide | 263 EUR |
Inoltre, sono state generate due DP ciascuna in seguito all’interazione del farmaco e dell’acido tazarotenico con HCl, utilizzato come stressante acido. Questi sono stati provati sperimentalmente come pseudo DP, poiché non hanno avuto origine quando H2SO4 è stato impiegato come fattore di stress. Il farmaco era anche instabile in condizioni ossidative e fotolitiche, producendo sei DP. Tutti i prodotti sono stati separati su colonna a fase inversa (C18), utilizzando una fase mobile composta da formiato di ammonio 10 mM (pH 3.5) e acetonitrile, che è stata eseguita in modalità gradiente. I DP separati sono stati sottoposti a studi LC-HRMS e LC-MSn per la loro caratterizzazione iniziale.