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Isotretinoina orale e uso topico di retinoidi in una serie di giovani pazienti con melanoma oculare

Isotretinoina orale e uso topico di retinoidi in una serie di giovani pazienti con melanoma oculare

Posted on Dicembre 4, 2020 By andrea Nessun commento su Isotretinoina orale e uso topico di retinoidi in una serie di giovani pazienti con melanoma oculare

Scopo: descrivere la prima serie di sei pazienti giovani con melanoma uveale (UM) con isotretinoina orale e / o terapia topica con retinoidi prima della diagnosi.

Osservazioni: la serie di casi si basa su osservazioni cliniche presso il nostro centro di riferimento quaternario UM. Vengono segnalati sei casi di pazienti UM, di età compresa tra 16 e 44 anni. Tutti avevano usato un trattamento con retinoidi orale (isotretinoina) e / o topico (tretinoina o tazarotene) (3 mesi- ~ 10 anni) prima o al momento della diagnosi (3 su 6 casi). Tutti i pazienti presentavano disturbi oculari e l’insorgenza di alcuni sintomi corrispondeva al decorso dei retinoidi. Altri potenziali fattori di rischio o anamnesi rilevante includevano sfondo caucasico, distrofia conica e stato di fumatore attivo (caso 2), storia familiare di UM e gravidanza al momento della diagnosi (caso 3), fumo passato e possibile esposizione secondaria a Chernobyl da bambino ( Caso 5). Tutti i pazienti sono stati trattati con radioterapia a fascio di protoni e attualmente non hanno segni di malattia recidivante o metastatica.

Conclusioni e importanza: la terapia con retinoidi è stata collegata a vari effetti benigni e / o reversibili sull’occhio anteriore e posteriore, sebbene la fisiopatologia non sia ancora ben compresa. Il melanoma uveale (UM) è una rara diagnosi di cancro nei giovani adulti. Riportiamo qui la prima serie di casi di giovani pazienti di UM con una storia di uso di retinoidi e disturbi oculari. Non viene affermato alcun nesso causale e ulteriori studi epidemiologici e biologici sistematici sulla terapia con retinoidi e sull’impatto oculare possono fornire ulteriori dati rilevanti, in particolare nei pazienti giovani con melanoma oculare.

 

Aggiornamento teratogeno: uso topico e retinoidi di terza generazione

I primi retinoidi farmaceutici approvati dalla Food and Drug Administration degli Stati Uniti hanno ricevuto avvertimenti da scatola nera contro il loro uso in gravidanza a causa di potenziali effetti teratogeni. Questi retinoidi di prima e seconda generazione sono stati inizialmente formulati per il dosaggio orale e sono strutturalmente molto simili alla vitamina A, che ha effetti benefici sulla pelle e svolge un ruolo fondamentale nel guidare l’embriogenesi sana. Da allora, alcuni di questi retinoidi precoci sono stati riformulati per l’applicazione topica, il che ha ridotto il loro potenziale di esposizione sistemica. Inoltre, la progettazione razionale dei farmaci è stata applicata per creare i retinoidi di terza generazione di oggi (adapalene, tazarotene e bexarotene).

Questi composti includono anelli aromatici all’interno dei loro nuclei molecolari per fornire una rigidità strutturale che contrasta con la spina dorsale alifatica flessibile della vitamina A e delle precedenti generazioni di retinoidi, e quindi limita la loro attività fuori bersaglio. Come risultato di queste caratteristiche progettuali, il potenziale teratogeno negli animali dei retinoidi di terza generazione e in quelli riformulati per uso topico è generalmente inferiore a quello osservato con la somministrazione orale di generazioni precedenti di retinoidi. I dati epidemiologici disponibili, ma limitati, mostrano inoltre un potenziale teratogeno minimo o nullo associato all’uso nella vita reale di questi composti nell’uomo. Data la scarsità di dati epidemiologici disponibili in questo momento, tuttavia, si raccomanda di evitare l’uso di retinoidi topici durante la gravidanza. Tuttavia, in circostanze in cui può verificarsi un’esposizione involontaria in gravidanza, i dati disponibili forniscono una certa rassicurazione sul fatto che gli esiti avversi della gravidanza sono improbabili.

Isotretinoina orale e uso topico di retinoidi in una serie di giovani pazienti con melanoma oculare
Isotretinoina orale e uso topico di retinoidi in una serie di giovani pazienti con melanoma oculare

 

Chemerin come un driver di ipertensione: una considerazione

La proteina chemerina (gene indotto dal tazarotene, TIG2; RARRES2) è un’adipochina relativamente nuova. Molti studi supportano che i livelli di chemerina circolanti si associano fortemente e positivamente con BMI, grasso viscerale e pressione sanguigna. Qui, ci concentriamo sulla relazione specifica tra chemerina e pressione sanguigna con l’obiettivo di capire se e come la chemerina guida i cambiamenti (patologici) della pressione sanguigna in modo tale da poter essere interferiti terapeuticamente. Analizziamo la biosintesi della chemerina e come gli attuali farmaci antipertensivi modificano il metabolismo delle chemerine. Segue una rassegna di ciò che è noto su dove la chemerina è sintetizzata nel corpo e cosa possono fare la chemerina ei suoi recettori per la funzione fisiologica degli organi importanti per la determinazione della pressione sanguigna (ad es. Cervello, cuore, reni, vasi sanguigni, surrene e sistema nervoso simpatico).

Sintetizziamo dalla letteratura la nostra migliore comprensione dei meccanismi con cui la chemerina modifica la pressione sanguigna, con la consapevolezza che i livelli plasmatici / sierici di chemerina possono essere limitati nella loro rilevanza patologica. Questa revisione rivela diverse lacune nella nostra conoscenza della biologia delle chemerine che potrebbero essere colmate dal lavoro collettivo di chimici delle proteine, biologi, farmacologi e medici. Il tazarotene è un profarmaco che appartiene alla classe acetilenica dei retinoidi. Il farmaco è stato sottoposto a stress test idrolitico, ossidativo e fotolitico per stabilire la sua chimica di degradazione completa. Il farmaco si è dimostrato instabile in condizioni idrolitiche acide e basiche, producendo acido tazarotenico, che è un noto prodotto di degradazione principale (DP) e un metabolita attivo.

Rabbit OVARY MATURE 50 EA*

41329-2 Pel-Freez 50 EA 382.07 EUR

Rabbit PANCREAS MATURE 25 EA*

41331-2 Pel-Freez 25 EA 409.48 EUR

Rabbit SUBMAXILLARY MATURE 50 EA

41343-2 Pel-Freez 50 EA 382.07 EUR

Rabbit THYROID MATURE 50 EA*

41352-1 Pel-Freez 50 EA 366.41 EUR

Soft Tissue Tissue Slide (Skeletal Muscle-Normal)

12-341-10um ProSci 10 um 241.8 EUR

Soft Tissue Tissue Slide (Skeletal Muscle-Normal)

12-341-4um ProSci 4 um 216.6 EUR

Soft Tissue Tissue Slide (Skeletal Muscle-Benign)

12-343-10um ProSci 10 um 241.8 EUR

Soft Tissue Tissue Slide (Skeletal Muscle-Benign)

12-343-4um ProSci 4 um 216.6 EUR

Soft Tissue Tissue Slide (Skeletal Muscle-malignant)

12-345-10um ProSci 10 um 241.8 EUR

Soft Tissue Tissue Slide (Skeletal Muscle-malignant)

12-345-4um ProSci 4 um 216.6 EUR

Rabbit LUNG UNTRIMMED MATURE 20 PR

41324-2 Pel-Freez 20 PR 323.34 EUR

Rat Skeletal Muscle Tissue Lysate

LYSATE0010 BosterBio 200ug 180 EUR
Description: This cell lysate is prepared from rat skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C.

Mouse Skeletal Muscle Tissue Lysate

LYSATE0021 BosterBio 200ug 180 EUR
Description: This cell lysate is prepared from mouse skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C.

Frozen Tissue Section - Human Diabetic Tissue: Skeletal Muscle

T1236171Dia Biochain 5 slides 558 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Diabetic Tissue: Skeletal Muscle

T2236171Dia Biochain 5 slides 308.4 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Smooth muscle and striated muscle disease spectrum tissue array

SO8011 TissueArray each 414 EUR
Description: Smooth muscle and striated muscle disease spectrum tissue array, including TNM and clinical stage, 80 cases /80 cores

Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array

SO2081 TissueArray each 474 EUR
Description: Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array, 104 cases/208 cores

Actin, Rabbit Muscle

P1246-1000 Biovision each 274.8 EUR

Actin, Rabbit Muscle

P1246-500 Biovision each 196.8 EUR

Human Muscle OptiTDS1: Tissue Dissociation System

4-28091 CHI Scientific 1 Kit Ask for price

Human Muscle OptiTDS2: Tissue Dissociation System

4-28092 CHI Scientific 1 Kit Ask for price

Mouse Muscle OptiTDS1: Tissue Dissociation System

4-28188 CHI Scientific 1 Kit Ask for price

Mouse Muscle OptiTDS2: Tissue Dissociation System

4-28189 CHI Scientific 1 Kit Ask for price

Rat Muscle OptiTDS1: Tissue Dissociation System

4-28280 CHI Scientific 1 Kit Ask for price

Rat Muscle OptiTDS2: Tissue Dissociation System

4-28281 CHI Scientific 1 Kit Ask for price

Mouse Skeletal Muscle Whole tissue lysate

MAL-1407 Alpha Diagnostics 1 mg 628.8 EUR

Rat Skeletal Muscle Whole tissue lysate

RAL-1467 Alpha Diagnostics 1 mg 628.8 EUR

Rhabdomyosarcoma with striated muscle tissue array

SO2082b TissueArray each 546 EUR
Description: Rhabdomyosarcoma with striated muscle tissue array, including TNM and clinical stage, 104 cases/208 cores, replacing SO2082a

Human Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells

9-80091 CHI Scientific 1 x 100 ml Ask for price

Human Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells

9-80092 CHI Scientific 1 x 100 ml Ask for price

Mouse Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells

9-80188 CHI Scientific 1 x 100 ml Ask for price

Mouse Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells

9-80189 CHI Scientific 1 x 100 ml Ask for price

Rat Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells

9-80280 CHI Scientific 1 x 100 ml Ask for price

Rat Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells

9-80281 CHI Scientific 1 x 100 ml Ask for price

cDNA from Human Tumor Tissue: Skeletal Muscle

C1235171-10 Biochain 10 reactions 338.4 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Diabetic Tissue: Skeletal Muscle

C1236171Dia Biochain 40 reactions 801.6 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Skeletal Muscle

C1334171 Biochain 40 reactions 451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Skeletal Muscle

C1434171 Biochain 40 reactions 451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Skeletal Muscle

C1734171 Biochain 40 reactions 451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Aldolase (Rabbit Muscle) Antibody

abx022821-50mg Abbexa 50 mg 1262.4 EUR

Mature Macrophage Marker antibody

10R-6351 Fitzgerald 100 ug 522 EUR
Description: Mouse monoclonal Mature Macrophage Marker antibody

INHA (mature form) Antibody

abx431358-200ul Abbexa 200 ul 343.2 EUR

Anti-mature BDNF antibody

STJ13100056 St John's Laboratory 100 µl 512.4 EUR

Anti-mature BDNF antibody

STJ13100057 St John's Laboratory 100 µl 512.4 EUR

Anti-mature BDNF antibody

STJ13100064 St John's Laboratory 100 µl 512.4 EUR

cDNA from Human Adult Normal Tissue: Skeletal Muscle

C1234171 Biochain 40 reactions 451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Skeletal Muscle

C1534171 Biochain 40 reactions 451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle

C1534171-Cy Biochain 40 reactions 451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Mouse Normal Tissue: Skeletal Muscle

D1334171 Biochain 100 ug 338.4 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Rat Normal Tissue: Skeletal Muscle

D1434171 Biochain 100 ug 338.4 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total Protein from Human Tumor Tissue: Skeletal Muscle

P1235171 Biochain 1 mg 384 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Human Diabetic Tissue: Skeletal Muscle

P1236171Dia Biochain 1 mg 553.2 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Mouse Normal Tissue: Skeletal Muscle

P1334171 Biochain 1 mg 256.8 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Monkey (Cyno.) Normal Skeletal Muscle Whole tissue lysate

MCL-1197 Alpha Diagnostics 1 mg 628.8 EUR

Monkey (Rhesus) Normal Skeletal Muscle Whole tissue lysate

MRL-1247 Alpha Diagnostics 1 mg 628.8 EUR

Human Adult Skeletal Muscle (Normal) Whole tissue lysate

HAL-1375 Alpha Diagnostics 1 mg 628.8 EUR

Total RNA from Mouse Normal Tissue: Skeletal Muscle

R1334171-50 Biochain 50 ug 182.4 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Skeletal Muscle

R1434171-50 Biochain 50 ug 182.4 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Frozen Tissue Section - Human Adult Normal: Skeletal Muscle

T1234171 Biochain 5 slides 418.8 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Adult Normal: Skeletal Muscle

T2234171 Biochain 5 slides 253.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Tissue Factor Rabbit mAb

A4395-100ul Abclonal 100 ul 492 EUR

Tissue Factor Rabbit mAb

A4395-200ul Abclonal 200 ul 685.2 EUR

Tissue Factor Rabbit mAb

A4395-20ul Abclonal 20 ul 265.2 EUR

Tissue Factor Rabbit mAb

A4395-50ul Abclonal 50 ul 344.4 EUR

Rabbit Liver Tissue Lysate

30R-AL003 Fitzgerald 150 ug 302.4 EUR
Description: Fresh tissue lysate prepared from rabbit liver

Purified (>95%) muscle Actin Protein from muscle (rabbit/bovine)

ACTB15-N-1 Alpha Diagnostics 1 mg 489.6 EUR

Rabbit Skeletal Muscle Troponin-C

7-06205 CHI Scientific 1mg Ask for price

Rabbit Skeletal Muscle Troponin-C

7-06206 CHI Scientific 5mg Ask for price

Rabbit Skeletal Muscle Troponin-C

7-06207 CHI Scientific 10mg Ask for price

Rabbit MUSCLE ACETONE POWDER 10g

41995-2 Pel-Freez 10g 328.56 EUR

alpha Actin (Skeletal Muscle) (Rabbit)

30R-3107 Fitzgerald 1 mg 308.4 EUR
Description: Purified native alpha Actin (Skeletal Muscle) (Rabbit)

Actin, pyrene labeled, Rabbit Muscle

M1319-1000 Biovision each 222 EUR

Actin, pyrene labeled, Rabbit Muscle

M1319-500 Biovision each 183.6 EUR

Rabbit Anti Human Carboxypeptidase H (Mature N-Terminal) Polyclonal Antibody

CPBT-66584RH Creative Diagnostics 0.1 ml 920.4 EUR

Mature Macrophage Marker antibody (biotin)

61R-1470 Fitzgerald 100 ug 573.6 EUR
Description: Mouse monoclonal Mature Macrophage Marker antibody (biotin)

ATP synthase C mature antibody

22398-100ul SAB 100ul 468 EUR

Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I

T6834700-G01-1 Biochain 1 slide 309.6 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I

T6834700-G01-5 Biochain 5 slides 985.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I

T6834700-G02-1 Biochain 1 slide 309.6 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I

T6834700-G02-5 Biochain 5 slides 985.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Total Protein from Human Adult Normal Tissue: Skeletal Muscle

P1234171 Biochain 1 mg 256.8 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Membrane Protein from Human Adult Normal Tissue: Skeletal Muscle

P3234171 Biochain 0.1 mg 342 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA from Monkey (Rhesus) Normal Tissue: Skeletal Muscle

R1534171-50 Biochain 50 ug 232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle

R1534171-Cy Biochain 50 ug 232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Muscle: Diaphragm

R1234169-10 Biochain 10 ug 232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Skeletal Muscle

R1234171-50 Biochain 50 ug 213.6 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Paraffin Tissue Section - Human Adult Normal: Heart: Papilla Muscle

T2234132 Biochain 5 slides 253.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Rabbit Tissue Factor ELISA kit

E04T0037-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tissue Factor ELISA kit

E04T0037-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tissue Factor ELISA kit

E04T0037-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tissue Transglutaminase ELISA kit

E04T0766-192T BlueGene 192 tests 1524 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Tissue Transglutaminase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tissue Transglutaminase ELISA kit

E04T0766-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Tissue Transglutaminase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tissue Transglutaminase ELISA kit

E04T0766-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Tissue Transglutaminase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tissue Factor (TF) Protein

20-abx069317 Abbexa
  • 744.00 EUR
  • 326.40 EUR
  • 2230.80 EUR
  • 878.40 EUR
  • 543.60 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rabbit Tissue factor ELISA Kit

ELA-E0524Rb Lifescience Market 96 Tests 1113.6 EUR

Rabbit Anti Actin (Muscle) Polyclonal Antibody

CPBT-68162RA Creative Diagnostics 0.5 ml 1057.2 EUR

alpha smooth muscle actin Rabbit pAb

A7248-100ul Abclonal 100 ul 369.6 EUR

alpha smooth muscle actin Rabbit pAb

A7248-200ul Abclonal 200 ul 550.8 EUR

alpha smooth muscle actin Rabbit pAb

A7248-20ul Abclonal 20 ul 219.6 EUR

alpha smooth muscle actin Rabbit pAb

A7248-50ul Abclonal 50 ul 267.6 EUR

Rabbit Creatine Kinase, Muscle ELISA kit

E04C0400-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Creatine Kinase, Muscle ELISA kit

E04C0400-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Creatine Kinase, Muscle ELISA kit

E04C0400-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Cofilin 2, Muscle ELISA kit

E04C0470-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Cofilin 2, Muscle ELISA kit

E04C0470-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Cofilin 2, Muscle ELISA kit

E04C0470-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Eye muscle antibody ELISA kit

E04E0148-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Eye muscle antibody ELISA kit

E04E0148-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Eye muscle antibody ELISA kit

E04E0148-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Glycogen Phosphorylase, Muscle ELISA kit

E04P0170-192T BlueGene 192 tests 1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Glycogen Phosphorylase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Glycogen Phosphorylase, Muscle ELISA kit

E04P0170-48 BlueGene 1 plate of 48 wells 624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Glycogen Phosphorylase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Glycogen Phosphorylase, Muscle ELISA kit

E04P0170-96 BlueGene 1 plate of 96 wells 822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Glycogen Phosphorylase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

alpha smooth muscle actin Rabbit pAb

A0957-100ul Abclonal 100 ul 460.8 EUR

alpha smooth muscle actin Rabbit pAb

A0957-200ul Abclonal 200 ul Ask for price

alpha smooth muscle actin Rabbit pAb

A0957-20ul Abclonal 20 ul Ask for price

alpha smooth muscle actin Rabbit pAb

A0957-50ul Abclonal 50 ul 318 EUR

alpha smooth muscle actin Rabbit pAb

A1011-100ul Abclonal 100 ul 369.6 EUR

alpha smooth muscle actin Rabbit pAb

A1011-200ul Abclonal 200 ul 550.8 EUR

alpha smooth muscle actin Rabbit pAb

A1011-20ul Abclonal 20 ul 219.6 EUR

alpha smooth muscle actin Rabbit pAb

A1011-50ul Abclonal 50 ul 267.6 EUR

Rabbit MUSCLE ACETONE POWDER (1-g)

41995-1 Pel-Freez 1g 144.55 EUR

Troponin I protein (Skeletal Muscle) (Rabbit)

30-1015 Fitzgerald 100 ug 582 EUR
Description: Purified native Rabbit Troponin I protein (Skeletal Muscle)

Troponin C protein (Skeletal Muscle) (Rabbit)

30-1020 Fitzgerald 1 mg 1059.6 EUR
Description: Purified native Rabbit Troponin C protein (Skeletal Muscle)

Rabbit Enolase, Muscle Specific (MSE) Protein

20-abx066421 Abbexa
  • 794.40 EUR
  • 326.40 EUR
  • 2448.00 EUR
  • 944.40 EUR
  • 577.20 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

alpha smooth muscle Actin Rabbit mAb

A17910 Abclonal 20 μL 18 EUR

alpha smooth muscle Actin Rabbit mAb

A17910-100ul Abclonal 100 ul 492 EUR

alpha smooth muscle Actin Rabbit mAb

A17910-200ul Abclonal 200 ul 685.2 EUR

alpha smooth muscle Actin Rabbit mAb

A17910-20ul Abclonal 20 ul 265.2 EUR

alpha smooth muscle Actin Rabbit mAb

A17910-50ul Abclonal 50 ul 344.4 EUR

Rabbit Skeletal Muscle Troponin-C Protein

20-abx260177 Abbexa
  • 1646.40 EUR
  • 393.60 EUR
  • 1028.40 EUR
  • 10 mg
  • 1 mg
  • 5 mg

Rabbit Phosphofructokinase, Muscle (PFKM) ELISA Kit

abx363038-96tests Abbexa 96 tests 990 EUR

Rabbit Creatine Kinase, Muscle (CKM) Protein

20-abx653071 Abbexa
  • 777.60 EUR
  • 326.40 EUR
  • 2397.60 EUR
  • 927.60 EUR
  • 560.40 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rabbit Phosphofructocinase Muscle(PFKM) ELISA Kit

QY-E30328 Qayee Biotechnology 96T 448.8 EUR

Creatine Kinase (CK/CPK), Rabbit Muscle

P1301-1 Biovision each 164.4 EUR

Creatine Kinase (CK/CPK), Rabbit Muscle

P1301-25 Biovision each 679.2 EUR

Human Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells

9-80100 CHI Scientific 1 x 100 ml Ask for price

Mouse Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells

9-80198 CHI Scientific 1 x 100 ml Ask for price

Rat Bladder Tissue Preparation Buffer 3: Normal Smooth Muscle Cells

9-80215 CHI Scientific 1 x 100 ml Ask for price

Rat Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells

9-80288 CHI Scientific 1 x 100 ml Ask for price

Total Protein from Human Adult Normal Tissue: Heart: Papilla Muscle

P1234132 Biochain 1 mg 596.4 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Human Soft Tissue Slide (Skeletal Muscle Normal) (5 slides/pk)

HTS-12341 Alpha Diagnostics 1 pk 343.2 EUR

Human Soft Tissue Slide (Skeletal Muscle Benign) (5 slides/pk)

HTS-12343 Alpha Diagnostics 1 pk 343.2 EUR

Human Soft Tissue Slide (Skeletal Muscle Malignant) (5 slides/pk)

HTS-12345 Alpha Diagnostics 1 pk 343.2 EUR

Total RNA from Human Adult Normal Tissue: Heart: Papilla Muscle

R1234132-10 Biochain 10 ug 232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Mature T-Cell Proliferation 1 Protein

20-abx261195 Abbexa
  • 4101.60 EUR
  • 393.60 EUR
  • 276.00 EUR
  • 1 mg
  • 20 ug
  • 5 ug
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Inoltre, sono state generate due DP ciascuna in seguito all’interazione del farmaco e dell’acido tazarotenico con HCl, utilizzato come stressante acido. Questi sono stati provati sperimentalmente come pseudo DP, poiché non hanno avuto origine quando H2SO4 è stato impiegato come fattore di stress. Il farmaco era anche instabile in condizioni ossidative e fotolitiche, producendo sei DP. Tutti i prodotti sono stati separati su colonna a fase inversa (C18), utilizzando una fase mobile composta da formiato di ammonio 10 mM (pH 3.5) e acetonitrile, che è stata eseguita in modalità gradiente. I DP separati sono stati sottoposti a studi LC-HRMS e LC-MSn per la loro caratterizzazione iniziale.

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