Isotretinoina orale e uso topico di retinoidi in una serie di giovani pazienti con melanoma oculare

Scopo: descrivere la prima serie di sei pazienti giovani con melanoma uveale (UM) con isotretinoina orale e / o terapia topica con retinoidi prima della diagnosi.

Osservazioni: la serie di casi si basa su osservazioni cliniche presso il nostro centro di riferimento quaternario UM. Vengono segnalati sei casi di pazienti UM, di età compresa tra 16 e 44 anni. Tutti avevano usato un trattamento con retinoidi orale (isotretinoina) e / o topico (tretinoina o tazarotene) (3 mesi- ~ 10 anni) prima o al momento della diagnosi (3 su 6 casi). Tutti i pazienti presentavano disturbi oculari e l’insorgenza di alcuni sintomi corrispondeva al decorso dei retinoidi. Altri potenziali fattori di rischio o anamnesi rilevante includevano sfondo caucasico, distrofia conica e stato di fumatore attivo (caso 2), storia familiare di UM e gravidanza al momento della diagnosi (caso 3), fumo passato e possibile esposizione secondaria a Chernobyl da bambino ( Caso 5). Tutti i pazienti sono stati trattati con radioterapia a fascio di protoni e attualmente non hanno segni di malattia recidivante o metastatica.

Conclusioni e importanza: la terapia con retinoidi è stata collegata a vari effetti benigni e / o reversibili sull’occhio anteriore e posteriore, sebbene la fisiopatologia non sia ancora ben compresa. Il melanoma uveale (UM) è una rara diagnosi di cancro nei giovani adulti. Riportiamo qui la prima serie di casi di giovani pazienti di UM con una storia di uso di retinoidi e disturbi oculari. Non viene affermato alcun nesso causale e ulteriori studi epidemiologici e biologici sistematici sulla terapia con retinoidi e sull’impatto oculare possono fornire ulteriori dati rilevanti, in particolare nei pazienti giovani con melanoma oculare.

Aggiornamento teratogeno: uso topico e retinoidi di terza generazione

I primi retinoidi farmaceutici approvati dalla Food and Drug Administration degli Stati Uniti hanno ricevuto avvertimenti da scatola nera contro il loro uso in gravidanza a causa di potenziali effetti teratogeni. Questi retinoidi di prima e seconda generazione sono stati inizialmente formulati per il dosaggio orale e sono strutturalmente molto simili alla vitamina A, che ha effetti benefici sulla pelle e svolge un ruolo fondamentale nel guidare l’embriogenesi sana. Da allora, alcuni di questi retinoidi precoci sono stati riformulati per l’applicazione topica, il che ha ridotto il loro potenziale di esposizione sistemica. Inoltre, la progettazione razionale dei farmaci è stata applicata per creare i retinoidi di terza generazione di oggi (adapalene, tazarotene e bexarotene).

Questi composti includono anelli aromatici all’interno dei loro nuclei molecolari per fornire una rigidità strutturale che contrasta con la spina dorsale alifatica flessibile della vitamina A e delle precedenti generazioni di retinoidi, e quindi limita la loro attività fuori bersaglio. Come risultato di queste caratteristiche progettuali, il potenziale teratogeno negli animali dei retinoidi di terza generazione e in quelli riformulati per uso topico è generalmente inferiore a quello osservato con la somministrazione orale di generazioni precedenti di retinoidi. I dati epidemiologici disponibili, ma limitati, mostrano inoltre un potenziale teratogeno minimo o nullo associato all’uso nella vita reale di questi composti nell’uomo. Data la scarsità di dati epidemiologici disponibili in questo momento, tuttavia, si raccomanda di evitare l’uso di retinoidi topici durante la gravidanza. Tuttavia, in circostanze in cui può verificarsi un’esposizione involontaria in gravidanza, i dati disponibili forniscono una certa rassicurazione sul fatto che gli esiti avversi della gravidanza sono improbabili.

Chemerin come un driver di ipertensione: una considerazione

La proteina chemerina (gene indotto dal tazarotene, TIG2; RARRES2) è un’adipochina relativamente nuova. Molti studi supportano che i livelli di chemerina circolanti si associano fortemente e positivamente con BMI, grasso viscerale e pressione sanguigna. Qui, ci concentriamo sulla relazione specifica tra chemerina e pressione sanguigna con l’obiettivo di capire se e come la chemerina guida i cambiamenti (patologici) della pressione sanguigna in modo tale da poter essere interferiti terapeuticamente. Analizziamo la biosintesi della chemerina e come gli attuali farmaci antipertensivi modificano il metabolismo delle chemerine. Segue una rassegna di ciò che è noto su dove la chemerina è sintetizzata nel corpo e cosa possono fare la chemerina ei suoi recettori per la funzione fisiologica degli organi importanti per la determinazione della pressione sanguigna (ad es. Cervello, cuore, reni, vasi sanguigni, surrene e sistema nervoso simpatico).

Sintetizziamo dalla letteratura la nostra migliore comprensione dei meccanismi con cui la chemerina modifica la pressione sanguigna, con la consapevolezza che i livelli plasmatici / sierici di chemerina possono essere limitati nella loro rilevanza patologica. Questa revisione rivela diverse lacune nella nostra conoscenza della biologia delle chemerine che potrebbero essere colmate dal lavoro collettivo di chimici delle proteine, biologi, farmacologi e medici. Il tazarotene è un profarmaco che appartiene alla classe acetilenica dei retinoidi. Il farmaco è stato sottoposto a stress test idrolitico, ossidativo e fotolitico per stabilire la sua chimica di degradazione completa. Il farmaco si è dimostrato instabile in condizioni idrolitiche acide e basiche, producendo acido tazarotenico, che è un noto prodotto di degradazione principale (DP) e un metabolita attivo.

Rabbit OVARY MATURE 50 EA*
41329-2	Pel-Freez	50 EA	382.07 EUR
Rabbit PANCREAS MATURE 25 EA*
41331-2	Pel-Freez	25 EA	409.48 EUR
Rabbit SUBMAXILLARY MATURE 50 EA
41343-2	Pel-Freez	50 EA	382.07 EUR
Rabbit THYROID MATURE 50 EA*
41352-1	Pel-Freez	50 EA	366.41 EUR
Soft Tissue Tissue Slide (Skeletal Muscle-Normal)
12-341-10um	ProSci	10 um	241.8 EUR
Soft Tissue Tissue Slide (Skeletal Muscle-Normal)
12-341-4um	ProSci	4 um	216.6 EUR
Soft Tissue Tissue Slide (Skeletal Muscle-Benign)
12-343-10um	ProSci	10 um	241.8 EUR
Soft Tissue Tissue Slide (Skeletal Muscle-Benign)
12-343-4um	ProSci	4 um	216.6 EUR
Soft Tissue Tissue Slide (Skeletal Muscle-malignant)
12-345-10um	ProSci	10 um	241.8 EUR
Soft Tissue Tissue Slide (Skeletal Muscle-malignant)
12-345-4um	ProSci	4 um	216.6 EUR
Rabbit LUNG UNTRIMMED MATURE 20 PR
41324-2	Pel-Freez	20 PR	323.34 EUR
Rat Skeletal Muscle Tissue Lysate
LYSATE0010	BosterBio	200ug	180 EUR
Description: This cell lysate is prepared from rat skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C.
Mouse Skeletal Muscle Tissue Lysate
LYSATE0021	BosterBio	200ug	180 EUR
Description: This cell lysate is prepared from mouse skeletal muscle tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C.
Frozen Tissue Section - Human Diabetic Tissue: Skeletal Muscle
T1236171Dia	Biochain	5 slides	558 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Paraffin Tissue Section - Human Diabetic Tissue: Skeletal Muscle
T2236171Dia	Biochain	5 slides	308.4 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Smooth muscle and striated muscle disease spectrum tissue array
SO8011	TissueArray	each	414 EUR
Description: Smooth muscle and striated muscle disease spectrum tissue array, including TNM and clinical stage, 80 cases /80 cores
Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array
SO2081	TissueArray	each	474 EUR
Description: Muscle disease spectrum (smooth muscle and striated muscle cancer progression) tissue array, 104 cases/208 cores
Actin, Rabbit Muscle
P1246-1000	Biovision	each	274.8 EUR
Actin, Rabbit Muscle
P1246-500	Biovision	each	196.8 EUR
Human Muscle OptiTDS1: Tissue Dissociation System
4-28091	CHI Scientific	1 Kit	Ask for price
Human Muscle OptiTDS2: Tissue Dissociation System
4-28092	CHI Scientific	1 Kit	Ask for price
Mouse Muscle OptiTDS1: Tissue Dissociation System
4-28188	CHI Scientific	1 Kit	Ask for price
Mouse Muscle OptiTDS2: Tissue Dissociation System
4-28189	CHI Scientific	1 Kit	Ask for price
Rat Muscle OptiTDS1: Tissue Dissociation System
4-28280	CHI Scientific	1 Kit	Ask for price
Rat Muscle OptiTDS2: Tissue Dissociation System
4-28281	CHI Scientific	1 Kit	Ask for price
Mouse Skeletal Muscle Whole tissue lysate
MAL-1407	Alpha Diagnostics	1 mg	628.8 EUR
Rat Skeletal Muscle Whole tissue lysate
RAL-1467	Alpha Diagnostics	1 mg	628.8 EUR
Rhabdomyosarcoma with striated muscle tissue array
SO2082b	TissueArray	each	546 EUR
Description: Rhabdomyosarcoma with striated muscle tissue array, including TNM and clinical stage, 104 cases/208 cores, replacing SO2082a
Human Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells
9-80091	CHI Scientific	1 x 100 ml	Ask for price
Human Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells
9-80092	CHI Scientific	1 x 100 ml	Ask for price
Mouse Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells
9-80188	CHI Scientific	1 x 100 ml	Ask for price
Mouse Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells
9-80189	CHI Scientific	1 x 100 ml	Ask for price
Rat Muscle Tissue Preparation Buffer 1: Normal Skeletal Muscle Cells
9-80280	CHI Scientific	1 x 100 ml	Ask for price
Rat Muscle Tissue Preparation Buffer 2: Normal Smooth Muscle Cells
9-80281	CHI Scientific	1 x 100 ml	Ask for price
cDNA from Human Tumor Tissue: Skeletal Muscle
C1235171-10	Biochain	10 reactions	338.4 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Human Diabetic Tissue: Skeletal Muscle
C1236171Dia	Biochain	40 reactions	801.6 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Mouse Normal Tissue: Skeletal Muscle
C1334171	Biochain	40 reactions	451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Rat Normal Tissue: Skeletal Muscle
C1434171	Biochain	40 reactions	451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Dog Normal Tissue: Skeletal Muscle
C1734171	Biochain	40 reactions	451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Aldolase (Rabbit Muscle) Antibody
abx022821-50mg	Abbexa	50 mg	1262.4 EUR
Mature Macrophage Marker antibody
10R-6351	Fitzgerald	100 ug	522 EUR
Description: Mouse monoclonal Mature Macrophage Marker antibody
INHA (mature form) Antibody
abx431358-200ul	Abbexa	200 ul	343.2 EUR
Anti-mature BDNF antibody
STJ13100056	St John's Laboratory	100 µl	512.4 EUR
Anti-mature BDNF antibody
STJ13100057	St John's Laboratory	100 µl	512.4 EUR
Anti-mature BDNF antibody
STJ13100064	St John's Laboratory	100 µl	512.4 EUR
cDNA from Human Adult Normal Tissue: Skeletal Muscle
C1234171	Biochain	40 reactions	451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Monkey (Rhesus) Normal Tissue: Skeletal Muscle
C1534171	Biochain	40 reactions	451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle
C1534171-Cy	Biochain	40 reactions	451.2 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Genomic DNA from Mouse Normal Tissue: Skeletal Muscle
D1334171	Biochain	100 ug	338.4 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Genomic DNA from Rat Normal Tissue: Skeletal Muscle
D1434171	Biochain	100 ug	338.4 EUR
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Total Protein from Human Tumor Tissue: Skeletal Muscle
P1235171	Biochain	1 mg	384 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Human Diabetic Tissue: Skeletal Muscle
P1236171Dia	Biochain	1 mg	553.2 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Mouse Normal Tissue: Skeletal Muscle
P1334171	Biochain	1 mg	256.8 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Monkey (Cyno.) Normal Skeletal Muscle Whole tissue lysate
MCL-1197	Alpha Diagnostics	1 mg	628.8 EUR
Monkey (Rhesus) Normal Skeletal Muscle Whole tissue lysate
MRL-1247	Alpha Diagnostics	1 mg	628.8 EUR
Human Adult Skeletal Muscle (Normal) Whole tissue lysate
HAL-1375	Alpha Diagnostics	1 mg	628.8 EUR
Total RNA from Mouse Normal Tissue: Skeletal Muscle
R1334171-50	Biochain	50 ug	182.4 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Total RNA from Rat Normal Tissue: Skeletal Muscle
R1434171-50	Biochain	50 ug	182.4 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Frozen Tissue Section - Human Adult Normal: Skeletal Muscle
T1234171	Biochain	5 slides	418.8 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Paraffin Tissue Section - Human Adult Normal: Skeletal Muscle
T2234171	Biochain	5 slides	253.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Tissue Factor Rabbit mAb
A4395-100ul	Abclonal	100 ul	492 EUR
Tissue Factor Rabbit mAb
A4395-200ul	Abclonal	200 ul	685.2 EUR
Tissue Factor Rabbit mAb
A4395-20ul	Abclonal	20 ul	265.2 EUR
Tissue Factor Rabbit mAb
A4395-50ul	Abclonal	50 ul	344.4 EUR
Rabbit Liver Tissue Lysate
30R-AL003	Fitzgerald	150 ug	302.4 EUR
Description: Fresh tissue lysate prepared from rabbit liver
Purified (>95%) muscle Actin Protein from muscle (rabbit/bovine)
ACTB15-N-1	Alpha Diagnostics	1 mg	489.6 EUR
Rabbit Skeletal Muscle Troponin-C
7-06205	CHI Scientific	1mg	Ask for price
Rabbit Skeletal Muscle Troponin-C
7-06206	CHI Scientific	5mg	Ask for price
Rabbit Skeletal Muscle Troponin-C
7-06207	CHI Scientific	10mg	Ask for price
Rabbit MUSCLE ACETONE POWDER 10g
41995-2	Pel-Freez	10g	328.56 EUR
alpha Actin (Skeletal Muscle) (Rabbit)
30R-3107	Fitzgerald	1 mg	308.4 EUR
Description: Purified native alpha Actin (Skeletal Muscle) (Rabbit)
Actin, pyrene labeled, Rabbit Muscle
M1319-1000	Biovision	each	222 EUR
Actin, pyrene labeled, Rabbit Muscle
M1319-500	Biovision	each	183.6 EUR
Rabbit Anti Human Carboxypeptidase H (Mature N-Terminal) Polyclonal Antibody
CPBT-66584RH	Creative Diagnostics	0.1 ml	920.4 EUR
Mature Macrophage Marker antibody (biotin)
61R-1470	Fitzgerald	100 ug	573.6 EUR
Description: Mouse monoclonal Mature Macrophage Marker antibody (biotin)
ATP synthase C mature antibody
22398-100ul	SAB	100ul	468 EUR
Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I
T6834700-G01-1	Biochain	1 slide	309.6 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I
T6834700-G01-5	Biochain	5 slides	985.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I
T6834700-G02-1	Biochain	1 slide	309.6 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I
T6834700-G02-5	Biochain	5 slides	985.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Total Protein from Human Adult Normal Tissue: Skeletal Muscle
P1234171	Biochain	1 mg	256.8 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Membrane Protein from Human Adult Normal Tissue: Skeletal Muscle
P3234171	Biochain	0.1 mg	342 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total RNA from Monkey (Rhesus) Normal Tissue: Skeletal Muscle
R1534171-50	Biochain	50 ug	232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Total RNA from Monkey (Cynomolgus) Normal Tissue: Skeletal Muscle
R1534171-Cy	Biochain	50 ug	232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Total RNA from Human Adult Normal Tissue: Muscle: Diaphragm
R1234169-10	Biochain	10 ug	232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Total RNA from Human Adult Normal Tissue: Skeletal Muscle
R1234171-50	Biochain	50 ug	213.6 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Paraffin Tissue Section - Human Adult Normal: Heart: Papilla Muscle
T2234132	Biochain	5 slides	253.2 EUR
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Rabbit Tissue Factor ELISA kit
E04T0037-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Factor ELISA kit
E04T0037-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Factor ELISA kit
E04T0037-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Transglutaminase ELISA kit
E04T0766-192T	BlueGene	192 tests	1524 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Tissue Transglutaminase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Transglutaminase ELISA kit
E04T0766-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Tissue Transglutaminase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Transglutaminase ELISA kit
E04T0766-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A sandwich ELISA for quantitative measurement of Rabbit Tissue Transglutaminase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Factor (TF) Protein
20-abx069317	Abbexa	744.00 EUR 326.40 EUR 2230.80 EUR 878.40 EUR 543.60 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Rabbit Tissue factor ELISA Kit
ELA-E0524Rb	Lifescience Market	96 Tests	1113.6 EUR
Rabbit Anti Actin (Muscle) Polyclonal Antibody
CPBT-68162RA	Creative Diagnostics	0.5 ml	1057.2 EUR
alpha smooth muscle actin Rabbit pAb
A7248-100ul	Abclonal	100 ul	369.6 EUR
alpha smooth muscle actin Rabbit pAb
A7248-200ul	Abclonal	200 ul	550.8 EUR
alpha smooth muscle actin Rabbit pAb
A7248-20ul	Abclonal	20 ul	219.6 EUR
alpha smooth muscle actin Rabbit pAb
A7248-50ul	Abclonal	50 ul	267.6 EUR
Rabbit Creatine Kinase, Muscle ELISA kit
E04C0400-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Creatine Kinase, Muscle ELISA kit
E04C0400-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Creatine Kinase, Muscle ELISA kit
E04C0400-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Cofilin 2, Muscle ELISA kit
E04C0470-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Cofilin 2, Muscle ELISA kit
E04C0470-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Cofilin 2, Muscle ELISA kit
E04C0470-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Cofilin 2, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Eye muscle antibody ELISA kit
E04E0148-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Eye muscle antibody ELISA kit
E04E0148-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Eye muscle antibody ELISA kit
E04E0148-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Eye muscle antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Glycogen Phosphorylase, Muscle ELISA kit
E04P0170-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Glycogen Phosphorylase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Glycogen Phosphorylase, Muscle ELISA kit
E04P0170-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Glycogen Phosphorylase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Glycogen Phosphorylase, Muscle ELISA kit
E04P0170-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Glycogen Phosphorylase, Muscle in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
alpha smooth muscle actin Rabbit pAb
A0957-100ul	Abclonal	100 ul	460.8 EUR
alpha smooth muscle actin Rabbit pAb
A0957-200ul	Abclonal	200 ul	Ask for price
alpha smooth muscle actin Rabbit pAb
A0957-20ul	Abclonal	20 ul	Ask for price
alpha smooth muscle actin Rabbit pAb
A0957-50ul	Abclonal	50 ul	318 EUR
alpha smooth muscle actin Rabbit pAb
A1011-100ul	Abclonal	100 ul	369.6 EUR
alpha smooth muscle actin Rabbit pAb
A1011-200ul	Abclonal	200 ul	550.8 EUR
alpha smooth muscle actin Rabbit pAb
A1011-20ul	Abclonal	20 ul	219.6 EUR
alpha smooth muscle actin Rabbit pAb
A1011-50ul	Abclonal	50 ul	267.6 EUR
Rabbit MUSCLE ACETONE POWDER (1-g)
41995-1	Pel-Freez	1g	144.55 EUR
Troponin I protein (Skeletal Muscle) (Rabbit)
30-1015	Fitzgerald	100 ug	582 EUR
Description: Purified native Rabbit Troponin I protein (Skeletal Muscle)
Troponin C protein (Skeletal Muscle) (Rabbit)
30-1020	Fitzgerald	1 mg	1059.6 EUR
Description: Purified native Rabbit Troponin C protein (Skeletal Muscle)
Rabbit Enolase, Muscle Specific (MSE) Protein
20-abx066421	Abbexa	794.40 EUR 326.40 EUR 2448.00 EUR 944.40 EUR 577.20 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
alpha smooth muscle Actin Rabbit mAb
A17910	Abclonal	20 μL	18 EUR
alpha smooth muscle Actin Rabbit mAb
A17910-100ul	Abclonal	100 ul	492 EUR
alpha smooth muscle Actin Rabbit mAb
A17910-200ul	Abclonal	200 ul	685.2 EUR
alpha smooth muscle Actin Rabbit mAb
A17910-20ul	Abclonal	20 ul	265.2 EUR
alpha smooth muscle Actin Rabbit mAb
A17910-50ul	Abclonal	50 ul	344.4 EUR
Rabbit Skeletal Muscle Troponin-C Protein
20-abx260177	Abbexa	1646.40 EUR 393.60 EUR 1028.40 EUR	10 mg 1 mg 5 mg
Rabbit Phosphofructokinase, Muscle (PFKM) ELISA Kit
abx363038-96tests	Abbexa	96 tests	990 EUR
Rabbit Creatine Kinase, Muscle (CKM) Protein
20-abx653071	Abbexa	777.60 EUR 326.40 EUR 2397.60 EUR 927.60 EUR 560.40 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Rabbit Phosphofructocinase Muscle(PFKM) ELISA Kit
QY-E30328	Qayee Biotechnology	96T	448.8 EUR
Creatine Kinase (CK/CPK), Rabbit Muscle
P1301-1	Biovision	each	164.4 EUR
Creatine Kinase (CK/CPK), Rabbit Muscle
P1301-25	Biovision	each	679.2 EUR
Human Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells
9-80100	CHI Scientific	1 x 100 ml	Ask for price
Mouse Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells
9-80198	CHI Scientific	1 x 100 ml	Ask for price
Rat Bladder Tissue Preparation Buffer 3: Normal Smooth Muscle Cells
9-80215	CHI Scientific	1 x 100 ml	Ask for price
Rat Rectal Tissue Preparation Buffer: Normal Rectal Smooth Muscle Cells
9-80288	CHI Scientific	1 x 100 ml	Ask for price
Total Protein from Human Adult Normal Tissue: Heart: Papilla Muscle
P1234132	Biochain	1 mg	596.4 EUR
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Human Soft Tissue Slide (Skeletal Muscle Normal) (5 slides/pk)
HTS-12341	Alpha Diagnostics	1 pk	343.2 EUR
Human Soft Tissue Slide (Skeletal Muscle Benign) (5 slides/pk)
HTS-12343	Alpha Diagnostics	1 pk	343.2 EUR
Human Soft Tissue Slide (Skeletal Muscle Malignant) (5 slides/pk)
HTS-12345	Alpha Diagnostics	1 pk	343.2 EUR
Total RNA from Human Adult Normal Tissue: Heart: Papilla Muscle
R1234132-10	Biochain	10 ug	232.8 EUR
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Mature T-Cell Proliferation 1 Protein
20-abx261195	Abbexa	4101.60 EUR 393.60 EUR 276.00 EUR	1 mg 20 ug 5 ug

Inoltre, sono state generate due DP ciascuna in seguito all’interazione del farmaco e dell’acido tazarotenico con HCl, utilizzato come stressante acido. Questi sono stati provati sperimentalmente come pseudo DP, poiché non hanno avuto origine quando H2SO4 è stato impiegato come fattore di stress. Il farmaco era anche instabile in condizioni ossidative e fotolitiche, producendo sei DP. Tutti i prodotti sono stati separati su colonna a fase inversa (C18), utilizzando una fase mobile composta da formiato di ammonio 10 mM (pH 3.5) e acetonitrile, che è stata eseguita in modalità gradiente. I DP separati sono stati sottoposti a studi LC-HRMS e LC-MSn per la loro caratterizzazione iniziale.