La chinasi 5 del recettore accoppiato alla proteina G media la soppressione della crescita indotta dal gene 1 indotta dal tazarotene delle cellule di cancro del colon umano.

SFONDO
Il gene 1 indotto da tazarotene (TIG1) è un gene soppressore tumorale di tipo II inducibile dai retinoidi. L’isoforma B di TIG1 (TIG1B) inibisce la crescita e l’invasione delle cellule tumorali. L’espressione di TIG1B è spesso sottoregolata in vari tessuti tumorali; tuttavia, l’espressione e le attività dell’isoforma TIG1A devono ancora essere riportate. Pertanto, questo studio ha esaminato gli effetti delle isoforme TIG1A e TIG1B sulla crescita cellulare e sui profili di espressione genica utilizzando cellule di cancro del colon.

METODI
I cloni stabili TIG1A e TIG1B derivati ​​da cellule di cancro al colon HCT116 e SW620 sono stati stabiliti utilizzando il sistema GeneSwitch; L’espressione dell’isoforma TIG1 è stata indotta dal trattamento con mifepristone. La crescita cellulare è stata valutata utilizzando i test di proliferazione cellulare e formazione di colonie WST-1. L’interferenza dell’RNA è stata utilizzata per esaminare i cambiamenti di mediazione di TIG1 nella crescita cellulare. I profili di espressione genica sono stati determinati utilizzando microarray e convalidati utilizzando la reazione a catena della polimerasi in tempo reale e analisi Western blot.

RISULTATI
Entrambe le isoforme di TIG1 sono state espresse a livelli elevati nei tessuti normali della prostata e del colon e sono state sottoregolate nelle linee cellulari di cancro del colon. Entrambe le isoforme TIG1 hanno inibito in modo significativo la crescita di cellule HCT116 transitoriamente trasfettate ed esprimendo stabilmente cellule TIG1A e TIG1B HCT116 e SW620. L’espressione dei geni 129 e 55 è stata alterata all’induzione dell’espressione di TIG1A e TIG1B, rispettivamente, nelle cellule HCT116 che esprimono stabilmente. Dei geni analizzati, 23 e 6 geni erano rispettivamente sovraregolati e sottoregolati nelle cellule che esprimono TIG1A e TIG1B. La sovraregolazione della chinasi 5 del recettore accoppiato alla proteina G (GRK5) è stata confermata utilizzando la reazione a catena della polimerasi in tempo reale e analisi Western blot in entrambe le linee cellulari stabili TIG1. Il silenziamento dell’espressione di TIG1A o GRK5 ha ridotto significativamente la soppressione della crescita cellulare mediata da TIG1A.

CONCLUSIONI
L’espressione di entrambe le isoforme di TIG1 è stata osservata nei tessuti normali della prostata e del colon ed è stata sottoregolata nelle linee cellulari di cancro del colon. Entrambe le isoforme TIG1 hanno soppresso la crescita cellulare e stimolato l’espressione di GRK5 nelle cellule HCT116 e SW620. Il knockdown dell’espressione di GRK5 ha alleviato la soppressione della crescita indotta da TIG1A delle cellule HCT116, suggerendo che GRK5 media la soppressione della crescita cellulare da parte di TIG1A. Pertanto, TIG1 può partecipare alla sottoregolazione della segnalazione accoppiata alla proteina G sovraregolando l’espressione di GRK5.

Metodi spettrofotometrici che indicano la stabilità per la determinazione del tazarotene in presenza del suo prodotto di degradazione alcalino mediante tecniche spettrofotometriche derivate.

È stata studiata la stabilità del tazarotene (TZ) e sono stati utilizzati due metodi di indicazione della stabilità, vale a dire, il derivato primo e un metodo spettrofotometrico del rapporto dei derivati, per determinare il tazarotene in presenza del suo prodotto di degradazione alcalina (HD) utilizzando metanolo come solvente. È stata ottenuta una relazione lineare nell’intervallo 1-10 µg ml ¹ per entrambi i metodi.

Applicando i metodi proposti, è stato possibile determinare il tazarotene nella sua polvere pura da con precisione 99,35 ± 1,410 (n = 10) per il metodo della derivata prima e 99,45 ± 1,053 (n = 10) per il metodo del rapporto dei derivati. I metodi del derivato primo e del rapporto dei derivati ​​sono stati utilizzati per l’analisi di miscele preparate in laboratorio contenenti diversi rapporti di tazarotene e del suo prodotto di degradazione ed erano validi in presenza rispettivamente fino al 70% e all’80% di prodotto di degradazione. I metodi proposti sono stati convalidati e trovati adatti come metodi di analisi indicanti la stabilità per il tazarotene in formulazioni farmaceutiche.

[Retinoidi: meccanismi d’azione].

I retinoidi, derivati ​​della vitamina A, sono molecole naturali o sintetiche con effetti pleiotropici, che regolano il differenziamento, la proliferazione e l’apoptosi cellulare. Nella cellula bersaglio, i metaboliti naturali attivi acido retinoico (RA) e acido 9-cis-retinoico sono sintetizzati dal retinolo mediante un processo in due fasi con il metabolita intermedio retinaldeide. Nel 1987, l’identificazione dei recettori nucleari dell’acido retinoico che appartengono alla superfamiglia dei recettori nucleari ha portato a un progresso significativo nella comprensione del meccanismo d’azione dei retinoidi. Esistono due famiglie di recettori nucleari retinoidi (RNR), i recettori RA (RAR), il cui ligando naturale è RA, e i recettori X retinoidi (RXR), il cui ligando naturale è acido 9-cis-retinoico. Tra i retinoidi sintetici, isotretinoina, acitretina, tazarotene e adapalene sono ligandi del RAR, il bexarotene è il primo rexinoide (ligando dell’RXR), l’alitretinoina il primo panagonista (RAR + RXR).

Recombinant Rabbit Tissue factor pathway inhibitor Protein, His, E.coli-50ug
QP6775-ec-50ug	EnQuireBio	50ug	522 EUR
Recombinant Rabbit Tissue factor pathway inhibitor Protein, His, Yeast-1mg
QP6775-ye-1mg	EnQuireBio	1mg	3296.4 EUR
Recombinant Rabbit Tissue factor pathway inhibitor Protein, His, E.coli-100ug
QP6775-ec-100ug	EnQuireBio	100ug	848.4 EUR
Recombinant Rabbit Tissue factor pathway inhibitor Protein, His, E.coli-200ug
QP6775-ec-200ug	EnQuireBio	200ug	1338 EUR
Recombinant Rabbit Tissue factor pathway inhibitor Protein, His, E.coli-500ug
QP6775-ec-500ug	EnQuireBio	500ug	1816.8 EUR
Recombinant Rabbit Tissue factor pathway inhibitor Protein, His, Yeast-100ug
QP6775-ye-100ug	EnQuireBio	100ug	945.6 EUR
Recombinant Rabbit Tissue factor pathway inhibitor Protein, His, Yeast-10ug
QP6775-ye-10ug	EnQuireBio	10ug	434.4 EUR
Recombinant Rabbit Tissue factor pathway inhibitor Protein, His, Yeast-200ug
QP6775-ye-200ug	EnQuireBio	200ug	1512 EUR
Recombinant Rabbit Tissue factor pathway inhibitor Protein, His, Yeast-500ug
QP6775-ye-500ug	EnQuireBio	500ug	2164.8 EUR
Recombinant Rabbit Tissue factor pathway inhibitor Protein, His, Yeast-50ug
QP6775-ye-50ug	EnQuireBio	50ug	576 EUR
Recombinant Tissue Factor (TF)
4-RPA524Hu01	Cloud-Clone	603.84 EUR 285.60 EUR 1934.40 EUR 724.80 EUR 1329.60 EUR 480.00 EUR 4656.00 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tissue Factor expressed in: E.coli
Recombinant Tissue Factor (TF)
4-RPA524Mu01	Cloud-Clone	571.58 EUR 276.00 EUR 1813.44 EUR 684.48 EUR 1248.96 EUR 458.40 EUR 4353.60 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Tissue Factor expressed in: E.coli
Recombinant Tissue Factor (TF)
4-RPA524Ra01	Cloud-Clone	614.59 EUR 288.00 EUR 1974.72 EUR 738.24 EUR 1356.48 EUR 487.20 EUR 4756.80 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Tissue Factor expressed in: E.coli
Recombinant Tissue Factor (TF)
4-RPA524Rb01	Cloud-Clone	528.58 EUR 265.20 EUR 1652.16 EUR 630.72 EUR 1141.44 EUR 429.60 EUR 3950.40 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rabbit Tissue Factor expressed in: E.coli
Recombinant Tissue Factor (TF)
4-RPA524Bo01	Cloud-Clone	603.84 EUR 285.60 EUR 1934.40 EUR 724.80 EUR 1329.60 EUR 480.00 EUR 4656.00 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Bovine Tissue Factor expressed in: E.coli
Tissue Factor Recombinant Protein
40-663	ProSci	2 ug	311.1 EUR
Description: Tissue factor is a transmembrane glycoprotein of the cytokine receptor superfamily that acts as a receptor for coagulation factor VII (fVII) to trigger initiation of the coagulation cascade in response to vascular injury. Expression of tissue factor occurs constitutively within most extravascular and perivascular cells and at high levels within critical organs and tissue. Tissue factor is not normally expressed freely on the surface of circulating blood cells due to its pro-coagulant effect, but is instead stored on the surface of mononuclear and endothelial cells in microparticles that can shed into circulation in response to vascular injury, pro-inflammatory cytokines, or microbial ligands. Tissue factor can also be shed into circulation by cancer cells where its expression in a number of cancer types has been linked to tumor progression, metastatic potential, thrombosis, and angiogenesis. Expression of tissue factor has been shown to be inducible by select cytokines in a number of cell types, including IL-1β and TNF-α in vascular endothelial cells and macrophages, and TNF-α, IL-6, and FGF-Basic in monocytes, among others. CHO cell-derived Recombinant Human Tissue Factor is a glycoprotein homodimer comprised of the 214-amino-acid length monomer containing a C-terminal His-Tag. It has a calculated molecular weight of approximately 24.4 kDa, and as a result of glycosylation, Recombinant Human Tissue Factor migrates with an apparent molecular mass of approximately 45-55 kDa by SDS-PAGE gel, under reducing conditions.
Coagulation Factor III / Tissue Factor Recombinant Protein
11-118	ProSci	0.1 mg	714.3 EUR
Description: Full-length tissue factor (TF) is a transmembrane receptor and cofactor for factor (F)VII/FVIIa. In addition to full-length TF, an alternative spliced (as) form of TF can be generated that lacks the transmembrane domain and is released fromcells. In contrast to TF, asTF has low procoagulant activity because it lacks the transmembrane domain. Tissue factor is expressed by cells around blood vessels, such as adventitial fibroblasts, and body surfaces, such as epithelial cells, and plays a critical role in hemostasis. TF also contributes to various forms of thrombosis. Many cancers, particularly adenocarcinomas, express high levels of TF. A high level of tumor TF expression is associated with poor prognosis in many types of cancers, including breast, prostate, colorectal, and pancreatic cancer.
Coagulation Factor III / Tissue Factor Recombinant Protein
11-146	ProSci	0.1 mg	714.3 EUR
Description: Full-length tissue factor (TF) is a transmembrane receptor and cofactor for factor (F)VII/FVIIa. In addition to full-length TF, an alternative spliced (as) form of TF can be generated that lacks the transmembrane domain and is released fromcells. In contrast to TF, asTF has low procoagulant activity because it lacks the transmembrane domain. Tissue factor is expressed by cells around blood vessels, such as adventitial fibroblasts, and body surfaces, such as epithelial cells, and plays a critical role in hemostasis. TF also contributes to various forms of thrombosis. Many cancers, particularly adenocarcinomas, express high levels of TF. A high level of tumor TF expression is associated with poor prognosis in many types of cancers, including breast, prostate, colorectal, and pancreatic cancer.
Recombinant Mouse Tissue Factor (C-6His)
CU70-10ug	Novoprotein	10ug	242.4 EUR
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,0.05%Brij35,pH7.5.
Recombinant Mouse Tissue Factor (C-6His)
CU70-1mg	Novoprotein	1mg	2983.2 EUR
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,0.05%Brij35,pH7.5.
Recombinant Mouse Tissue Factor (C-6His)
CU70-500ug	Novoprotein	500ug	2106 EUR
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,0.05%Brij35,pH7.5.
Recombinant Mouse Tissue Factor (C-6His)
CU70-50ug	Novoprotein	50ug	595.2 EUR
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,0.05%Brij35,pH7.5.
Tissue Factor recombinant monoclonal antibody
A5658	Bimake	100ul X 3	714 EUR
Description: A recombinant monoclonal antibody from rabbit against human Tissue Factor for WB, IHC, IF,ELISA
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Hu01	Cloud-Clone	571.58 EUR 276.00 EUR 1813.44 EUR 684.48 EUR 1248.96 EUR 458.40 EUR 4353.60 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Hu02	Cloud-Clone	571.58 EUR 276.00 EUR 1813.44 EUR 684.48 EUR 1248.96 EUR 458.40 EUR 4353.60 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Hu03	Cloud-Clone	571.58 EUR 276.00 EUR 1813.44 EUR 684.48 EUR 1248.96 EUR 458.40 EUR 4353.60 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Mu01	Cloud-Clone	496.32 EUR 256.80 EUR 1531.20 EUR 590.40 EUR 1060.80 EUR 408.00 EUR 3648.00 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Ra01	Cloud-Clone	421.06 EUR 236.40 EUR 1248.96 EUR 496.32 EUR 872.64 EUR 357.60 EUR 2942.40 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Rb01	Cloud-Clone	614.59 EUR 288.00 EUR 1974.72 EUR 738.24 EUR 1356.48 EUR 487.20 EUR 4756.80 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rabbit Tissue Factor Pathway Inhibitor expressed in: E.coli
Tissue Factor Rabbit mAb
A4395-100ul	Abclonal	100 ul	492 EUR
Tissue Factor Rabbit mAb
A4395-200ul	Abclonal	200 ul	685.2 EUR
Tissue Factor Rabbit mAb
A4395-20ul	Abclonal	20 ul	265.2 EUR
Tissue Factor Rabbit mAb
A4395-50ul	Abclonal	50 ul	344.4 EUR
Recombinant Human Coagulation Factor III/Tissue Factor/CD142 Protein
RP00112	Abclonal	20 μg	448.8 EUR
Recombinant Human Tissue Factor Pathway Inhibitor 2
7-06643	CHI Scientific	2µg	Ask for price
Recombinant Human Tissue Factor Pathway Inhibitor 2
7-06644	CHI Scientific	5µg	Ask for price
Recombinant Human Tissue Factor Pathway Inhibitor 2
7-06645	CHI Scientific	10µg	Ask for price
Recombinant Tissue Factor Pathway Inhibitor 2 (TFPI2)
4-RPB940Bo01	Cloud-Clone	670.50 EUR 303.60 EUR 2184.38 EUR 808.13 EUR 1496.26 EUR 524.40 EUR 5280.96 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Bovine Tissue Factor Pathway Inhibitor 2 expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor 2 (TFPI2)
4-RPB940Hu01	Cloud-Clone	550.08 EUR 271.20 EUR 1732.80 EUR 657.60 EUR 1195.20 EUR 444.00 EUR 4152.00 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tissue Factor Pathway Inhibitor 2 expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor 2 (TFPI2)
4-RPB940Mu01	Cloud-Clone	603.84 EUR 285.60 EUR 1934.40 EUR 724.80 EUR 1329.60 EUR 480.00 EUR 4656.00 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Tissue Factor Pathway Inhibitor 2 expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor 2 (TFPI2)
4-RPB940Ra01	Cloud-Clone	657.60 EUR 300.00 EUR 2136.00 EUR 792.00 EUR 1464.00 EUR 516.00 EUR 5160.00 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Tissue Factor Pathway Inhibitor 2 expressed in: E.coli
Recombinant Human Coagulation Factor III/Tissue Factor/CD142 (C-6His)
C479-10ug	Novoprotein	10ug	242.4 EUR
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Recombinant Human Coagulation Factor III/Tissue Factor/CD142 (C-6His)
C479-1mg	Novoprotein	1mg	2739.6 EUR
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Recombinant Human Coagulation Factor III/Tissue Factor/CD142 (C-6His)
C479-500ug	Novoprotein	500ug	1935.6 EUR
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Recombinant Human Coagulation Factor III/Tissue Factor/CD142 (C-6His)
C479-50ug	Novoprotein	50ug	595.2 EUR
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Recombinant Connective Tissue Growth Factor (CTGF)
4-RPA010Hu02	Cloud-Clone	571.58 EUR 276.00 EUR 1813.44 EUR 684.48 EUR 1248.96 EUR 458.40 EUR 4353.60 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Connective Tissue Growth Factor expressed in: E.coli
Recombinant Connective Tissue Growth Factor (CTGF)
4-RPA010Mu01	Cloud-Clone	603.84 EUR 285.60 EUR 1934.40 EUR 724.80 EUR 1329.60 EUR 480.00 EUR 4656.00 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Connective Tissue Growth Factor expressed in: E.coli
Recombinant Connective Tissue Growth Factor (CTGF)
4-RPA010Ov01	Cloud-Clone	668.35 EUR 302.40 EUR 2176.32 EUR 805.44 EUR 1490.88 EUR 523.20 EUR 5260.80 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Sheep Connective Tissue Growth Factor expressed in: E.coli
Recombinant Connective Tissue Growth Factor (CTGF)
4-RPA010Ra01	Cloud-Clone	496.32 EUR 256.80 EUR 1531.20 EUR 590.40 EUR 1060.80 EUR 408.00 EUR 3648.00 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Connective Tissue Growth Factor expressed in: E.coli
Recombinant Connective Tissue Growth Factor (CTGF)
4-RPA010Bo01	Cloud-Clone	636.10 EUR 294.00 EUR 2055.36 EUR 765.12 EUR 1410.24 EUR 501.60 EUR 4958.40 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Bovine Connective Tissue Growth Factor expressed in: E.coli
Recombinant Connective Tissue Growth Factor (CTGF)
4-RPA010Hu01	Cloud-Clone	571.58 EUR 276.00 EUR 1813.44 EUR 684.48 EUR 1248.96 EUR 458.40 EUR 4353.60 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Connective Tissue Growth Factor expressed in: E.coli
Recombinant Connective Tissue Growth Factor (CTGF)
4-RPA010Po01	Cloud-Clone	636.10 EUR 294.00 EUR 2055.36 EUR 765.12 EUR 1410.24 EUR 501.60 EUR 4958.40 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Pig Connective Tissue Growth Factor expressed in: E.coli
Rabbit Tissue Factor ELISA kit
E04T0037-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Factor ELISA kit
E04T0037-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Factor ELISA kit
E04T0037-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue factor ELISA Kit
ELA-E0524Rb	Lifescience Market	96 Tests	1113.6 EUR
Recombinant Human Connective Tissue Growth Factor
7-00241	CHI Scientific	5µg	Ask for price
Recombinant Human Connective Tissue Growth Factor
7-00242	CHI Scientific	20µg	Ask for price
Recombinant Human Connective Tissue Growth Factor
7-00243	CHI Scientific	1mg	Ask for price
Rabbit Tissue Factor (TF) Protein
20-abx069317	Abbexa	744.00 EUR 326.40 EUR 2230.80 EUR 878.40 EUR 543.60 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Rabbit Tissue factor,TF ELISA Kit
CN-00654R1	ChemNorm	96T	536.4 EUR
Rabbit Tissue factor,TF ELISA Kit
CN-00654R2	ChemNorm	48T	355.2 EUR
Rabbit Tissue Factor (TF) ELISA Kit
DLR-TF-Rb-48T	DL Develop	48T	609.6 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Tissue Factor (TF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Rabbit Tissue Factor (TF) ELISA Kit
DLR-TF-Rb-96T	DL Develop	96T	793.2 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Tissue Factor (TF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Rabbit Tissue factor, TF ELISA Kit
CSB-E07006Rb-24T	Cusabio	1 plate of 24 wells	198 EUR
Description: Quantitativecompetitive ELISA kit for measuring Rabbit Tissue factor, TF in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Rabbit Tissue factor, TF ELISA Kit
1-CSB-E07006Rb	Cusabio	843.60 EUR 5811.60 EUR 3084.00 EUR	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativecompetitive ELISA kit for measuring Rabbit Tissue factor, TF in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Rabbit TF(Tissue Factor) ELISA Kit
ERB0118	FN Test	96T	681.12 EUR
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 9.375pg/ml
Rabbit tissue factor X ELISA kit
E04T0135-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit tissue factor X in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit tissue factor X ELISA kit
E04T0135-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit tissue factor X in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit tissue factor X ELISA kit
E04T0135-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit tissue factor X in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue factor,TF ELISA Kit
GA-E0209RB-48T	GenAsia Biotech	48T	391.2 EUR
Rabbit Tissue factor,TF ELISA Kit
GA-E0209RB-96T	GenAsia Biotech	96T	628.8 EUR
Rabbit Tissue factor,TF ELISA Kit
GA-E0210RB-48T	GenAsia Biotech	48T	391.2 EUR
Rabbit Tissue factor,TF ELISA Kit
GA-E0210RB-96T	GenAsia Biotech	96T	628.8 EUR
Rabbit Tissue Factor (TF) ELISA Kit
RDR-TF-Rb-48Tests	Reddot Biotech	48 Tests	640.8 EUR
Rabbit Tissue Factor (TF) ELISA Kit
RDR-TF-Rb-96Tests	Reddot Biotech	96 Tests	890.4 EUR
Rabbit Tissue Factor (TF) ELISA Kit
RD-TF-Rb-48Tests	Reddot Biotech	48 Tests	613.2 EUR
Rabbit Tissue Factor (TF) ELISA Kit
RD-TF-Rb-96Tests	Reddot Biotech	96 Tests	850.8 EUR
Rabbit Tissue Factor ELISA Kit (TF)
RK03441	Abclonal	96 Tests	625.2 EUR
Rabbit Tissue factor,TF ELISA Kit
QY-E30090	Qayee Biotechnology	96T	448.8 EUR
Rabbit Tissue Factor (TF) ELISA Kit
SEA524Rb-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	5552.14 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rabbit Tissue Factor (TF) in plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Rabbit Tissue Factor (TF) ELISA Kit
SEA524Rb-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	562.42 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rabbit Tissue Factor (TF) in plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Rabbit Tissue Factor (TF) ELISA Kit
SEA524Rb-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	752.02 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rabbit Tissue Factor (TF) in plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Rabbit Tissue Factor (TF) ELISA Kit
SEA524Rb-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	3024.07 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rabbit Tissue Factor (TF) in plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Rabbit Tissue Factor (TF) ELISA Kit
4-SEA524Rb	Cloud-Clone	5612.40 EUR 2965.20 EUR 752.40 EUR	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rabbit Tissue Factor (TF) in samples from plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.
Rabbit Tissue Factor (TF) ELISA Kit
RDR-TF-Rb-48T	Reddot Biotech	48T	465.47 EUR
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Rabbit Tissue Factor (TF) ELISA Kit
RDR-TF-Rb-96T	Reddot Biotech	96T	664.97 EUR
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Rabbit Tissue Factor (TF) ELISA Kit
RD-TF-Rb-48T	Reddot Biotech	48T	443.3 EUR
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Rabbit Tissue Factor (TF) ELISA Kit
RD-TF-Rb-96T	Reddot Biotech	96T	633.3 EUR
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Recombinant Human Connective Tissue Growth Factor, HEK
7-00250	CHI Scientific	2µg	Ask for price
Recombinant Human Connective Tissue Growth Factor, HEK
7-00251	CHI Scientific	10µg	Ask for price
Recombinant Human Connective Tissue Growth Factor, HEK
7-00252	CHI Scientific	100ug	Ask for price
Rabbit tissue factor VII ELISA kit
E04T0131-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit tissue factor VII in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit tissue factor VII ELISA kit
E04T0131-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit tissue factor VII in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit tissue factor VII ELISA kit
E04T0131-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit tissue factor VII in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
TFPI Tissue Factor Pathway Inhibitor Human Recombinant Protein
PROTP10646	BosterBio	Regular: 20ug	380.4 EUR
Description: TFPI Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 299 amino acids (29-304) and having a molecular mass of 34.3kDa.
Recombinant Human Connective Tissue Growth Factor 182-250 a.a.
7-00247	CHI Scientific	4µg	Ask for price
Recombinant Human Connective Tissue Growth Factor 182-250 a.a.
7-00248	CHI Scientific	20µg	Ask for price
Recombinant Human Connective Tissue Growth Factor 182-250 a.a.
7-00249	CHI Scientific	1mg	Ask for price
Recombinant Human Connective Tissue Growth Factor, His Tag
CG015-002	GenDepot	2ug	351.6 EUR
Recombinant Human Connective Tissue Growth Factor, His Tag
CG015-010	GenDepot	10ug	489.6 EUR
Recombinant Human Connective Tissue Growth Factor, His Tag
CG015-101	GenDepot	1mg	10752 EUR
Recombinant Human Connective Tissue Growth Factor, His Tag
7-00244	CHI Scientific	2µg	Ask for price
Recombinant Human Connective Tissue Growth Factor, His Tag
7-00245	CHI Scientific	10µg	Ask for price
Recombinant Human Connective Tissue Growth Factor, His Tag
7-00246	CHI Scientific	1mg	Ask for price
ELISA kit for Rabbit TF (Tissue Factor)
E-EL-RB0375	Elabscience Biotech	1 plate of 96 wells	700.8 EUR
Description: A sandwich ELISA kit for quantitative measurement of Rabbit TF (Tissue Factor) in samples from Serum, Plasma, Cell supernatant
ELISA kit for Rabbit Tissue factor (TF)
KTE90027-48T	Abbkine	48T	424.8 EUR
Description: Quantitative sandwich ELISA for measuring Rabbit Tissue factor (TF) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Rabbit Tissue factor (TF)
KTE90027-5platesof96wells	Abbkine	5 plates of 96 wells	2702.4 EUR
Description: Quantitative sandwich ELISA for measuring Rabbit Tissue factor (TF) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Rabbit Tissue factor (TF)
KTE90027-96T	Abbkine	96T	686.4 EUR
Description: Quantitative sandwich ELISA for measuring Rabbit Tissue factor (TF) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Rabbit TF (Tissue Factor)
ELK2443	ELK Biotech	1 plate of 96 wells	631.2 EUR
Description: A sandwich ELISA kit for detection of Tissue Factor from Rabbit in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
TFPI2 Tissue Factor Pathway Inhibitor 2 Human Recombinant Protein
PROTP48307	BosterBio	Regular: 5ug	380.4 EUR
Description: TFPI2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 199 amino acids (23-213 a.a.) and having a molecular mass of 22.9kDa (Migrates at 18-40kDa on SDS-PAGE under reducing conditions).;TFPI2 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Rabbit Tissue Factor / CD142 (F3) CLIA Kit
20-abx491579	Abbexa	10282.80 EUR 5472.00 EUR 1262.40 EUR	10 × 96 tests 5 × 96 tests 96 tests
Recombinant Human Connective Tissue Growth Factor/CTGF/CCN2
CM22-10ug	Novoprotein	10ug	187.2 EUR
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
Recombinant Human Connective Tissue Growth Factor/CTGF/CCN2
CM22-1mg	Novoprotein	1mg	2739.6 EUR
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
Recombinant Human Connective Tissue Growth Factor/CTGF/CCN2
CM22-500ug	Novoprotein	500ug	1935.6 EUR
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
Recombinant Human Connective Tissue Growth Factor/CTGF/CCN2
CM22-50ug	Novoprotein	50ug	442.8 EUR
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
Rabbit Tissue factor pathway inhibitor (TFPI)
1-CSB-BP023437RB	Cusabio	1008.00 EUR 398.40 EUR 2604.00 EUR 1362.00 EUR 1894.80 EUR 564.00 EUR	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rabbit Tissue factor pathway inhibitor(TFPI) expressed in Baculovirus
Rabbit Tissue factor pathway inhibitor (TFPI)
1-CSB-YP023437RB	Cusabio	814.80 EUR 402.00 EUR 2606.40 EUR 1261.20 EUR 1730.40 EUR 522.00 EUR	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rabbit Tissue factor pathway inhibitor(TFPI) expressed in Yeast
Rabbit Tissue factor pathway inhibitor (TFPI)
1-CSB-EP023437RB	Cusabio	733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40 EUR	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rabbit Tissue factor pathway inhibitor(TFPI) expressed in E.coli
Rabbit Tissue factor pathway inhibitor (TFPI)
1-CSB-MP023437RB	Cusabio	466.80 EUR 1672.80 EUR 675.60 EUR 1230.00 EUR	100ug 1MG 200ug 500ug
Description: Recombinant Rabbit Tissue factor pathway inhibitor(TFPI) expressed in Mammalian cell
CTGF Connective Tissue Growth Factor Human Recombinant Protein
PROTP29279-2	BosterBio	Regular: 20ug	380.4 EUR
Description: CTGF Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 98 amino acids and having a molecular mass of 11.2 kDa. ;The CTGF is purified by proprietary chromatographic techniques.
TFPI Human, Tissue Factor Pathway Inhibitor Human Recombinant Protein, Sf9
PROTP10646-1	BosterBio	Regular: 5ug	380.4 EUR
Description: TFPI Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 285 amino acids (29-304a.a.) and having a molecular mass of 33kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). TFPI is expressed with a 9 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
Tissue Factor (TF) Monoclonal Antibody (Rabbit)
4-MAA524Rb21	Cloud-Clone	301.20 EUR 3106.80 EUR 771.60 EUR 380.40 EUR 259.20 EUR	100ul 10ml 1ml 200ul 20ul
Description: A Mouse monoclonal antibody against Rabbit Tissue Factor (TF)
Tissue Factor (TF) Polyclonal Antibody (Rabbit)
4-PAA524Rb51	Cloud-Clone	291.60 EUR 2948.40 EUR 735.60 EUR 366.00 EUR 254.40 EUR	100ul 10ml 1ml 200ul 20ul
Description: A Guinea polyclonal antibody against Rabbit Tissue Factor (TF)
TF ELISA Kit| Rabbit Tissue Factor ELISA Kit
EF016877	Lifescience Market	96 Tests	826.8 EUR
Rabbit Tissue factor pathway inhibitor ELISA kit
E04T0509-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue factor pathway inhibitor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue factor pathway inhibitor ELISA kit
E04T0509-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue factor pathway inhibitor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue factor pathway inhibitor ELISA kit
E04T0509-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue factor pathway inhibitor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue factor pathway inhibitor ELISA Kit
ELA-E0394Rb	Lifescience Market	96 Tests	1113.6 EUR
Recombinant Human Connective Tissue Growth Factor/CTGF/CCN2 (C-Fc)
CI07-10ug	Novoprotein	10ug	242.4 EUR
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4.
Recombinant Human Connective Tissue Growth Factor/CTGF/CCN2 (C-Fc)
CI07-1mg	Novoprotein	1mg	2983.2 EUR
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4.
Recombinant Human Connective Tissue Growth Factor/CTGF/CCN2 (C-Fc)
CI07-500ug	Novoprotein	500ug	1935.6 EUR
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4.
Recombinant Human Connective Tissue Growth Factor/CTGF/CCN2 (C-Fc)
CI07-50ug	Novoprotein	50ug	595.2 EUR
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4.
Rabbit Tissue Factor Pathway Inhibitor (TFPI) Protein
20-abx069320	Abbexa	861.60 EUR 343.20 EUR 2665.20 EUR 1028.40 EUR 610.80 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor (TF) Monoclonal Antibody (Rabbit), PE
4-MAA524Rb21-PE	Cloud-Clone	362.40 EUR 3271.20 EUR 925.20 EUR 456.00 EUR 237.60 EUR	100ul 10ml 1ml 200ul 20ul
Description: A Mouse monoclonal antibody against Rabbit Tissue Factor (TF). This antibody is labeled with PE.
Tissue Factor (TF) Polyclonal Antibody (Rabbit), PE
4-PAA524Rb51-PE	Cloud-Clone	350.40 EUR 3098.40 EUR 882.00 EUR 439.20 EUR 232.80 EUR	100ul 10ml 1ml 200ul 20ul
Description: A Guinea polyclonal antibody against Rabbit Tissue Factor (TF). This antibody is labeled with PE.
Tissue Factor (TF) Monoclonal Antibody (Rabbit), APC
4-MAA524Rb21-APC	Cloud-Clone	422.40 EUR 4059.60 EUR 1126.80 EUR 540.00 EUR 267.60 EUR	100ul 10ml 1ml 200ul 20ul
Description: A Mouse monoclonal antibody against Rabbit Tissue Factor (TF). This antibody is labeled with APC.
Tissue Factor (TF) Monoclonal Antibody (Rabbit), Cy3
4-MAA524Rb21-Cy3	Cloud-Clone	513.60 EUR 5362.80 EUR 1453.20 EUR 670.80 EUR 306.00 EUR	100ul 10ml 1ml 200ul 20ul
Description: A Mouse monoclonal antibody against Rabbit Tissue Factor (TF). This antibody is labeled with Cy3.
Tissue Factor (TF) Monoclonal Antibody (Rabbit), HRP
4-MAA524Rb21-HRP	Cloud-Clone	386.40 EUR 3537.60 EUR 996.00 EUR 488.40 EUR 252.00 EUR	100ul 10ml 1ml 200ul 20ul
Description: A Mouse monoclonal antibody against Rabbit Tissue Factor (TF). This antibody is labeled with HRP.
Tissue Factor (TF) Polyclonal Antibody (Rabbit), APC
4-PAA524Rb51-APC	Cloud-Clone	408.00 EUR 3843.60 EUR 1072.80 EUR 518.40 EUR 260.40 EUR	100ul 10ml 1ml 200ul 20ul
Description: A Guinea polyclonal antibody against Rabbit Tissue Factor (TF). This antibody is labeled with APC.
Tissue Factor (TF) Polyclonal Antibody (Rabbit), Cy3
4-PAA524Rb51-Cy3	Cloud-Clone	493.20 EUR 5074.80 EUR 1381.20 EUR 642.00 EUR 297.60 EUR	100ul 10ml 1ml 200ul 20ul
Description: A Guinea polyclonal antibody against Rabbit Tissue Factor (TF). This antibody is labeled with Cy3.
Tissue Factor (TF) Polyclonal Antibody (Rabbit), HRP
4-PAA524Rb51-HRP	Cloud-Clone	373.20 EUR 3350.40 EUR 949.20 EUR 469.20 EUR 246.00 EUR	100ul 10ml 1ml 200ul 20ul
Description: A Guinea polyclonal antibody against Rabbit Tissue Factor (TF). This antibody is labeled with HRP.
Rabbit Coagulation Factor III, Tissue Factor / CD142 (F3) ELISA Kit
abx257083-96tests	Abbexa	96 tests	904.8 EUR
Rabbit Coagulation Factor III, Tissue Factor / CD142 (F3) ELISA Kit
20-abx155117	Abbexa	8684.40 EUR 4626.00 EUR 1074.00 EUR	10 × 96 tests 5 × 96 tests 96 tests
Rabbit Tissue Factor Pathway Inhibitor 2 ELISA kit
E04T0136-192T	BlueGene	192 tests	1524 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor Pathway Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Factor Pathway Inhibitor 2 ELISA kit
E04T0136-48	BlueGene	1 plate of 48 wells	624 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor Pathway Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Tissue Factor Pathway Inhibitor 2 ELISA kit
E04T0136-96	BlueGene	1 plate of 96 wells	822 EUR
Description: A competitive ELISA for quantitative measurement of Rabbit Tissue Factor Pathway Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Tissue Factor (TF) Monoclonal Antibody (Rabbit), FITC
4-MAA524Rb21-FITC	Cloud-Clone	362.40 EUR 3271.20 EUR 925.20 EUR 456.00 EUR 237.60 EUR	100ul 10ml 1ml 200ul 20ul
Description: A Mouse monoclonal antibody against Rabbit Tissue Factor (TF). This antibody is labeled with FITC.
Tissue Factor (TF) Polyclonal Antibody (Rabbit), FITC
4-PAA524Rb51-FITC	Cloud-Clone	350.40 EUR 3098.40 EUR 882.00 EUR 439.20 EUR 232.80 EUR	100ul 10ml 1ml 200ul 20ul
Description: A Guinea polyclonal antibody against Rabbit Tissue Factor (TF). This antibody is labeled with FITC.
Rabbit Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
20-abx491439	Abbexa	10282.80 EUR 5472.00 EUR 1262.40 EUR	10 × 96 tests 5 × 96 tests 96 tests
CTGF Connective Tissue Growth Factor Human Recombinant Protein (182-250 a.a.)
PROTP29279-1	BosterBio	Regular: 20ug	380.4 EUR
Description: The Connective Tissue Growth Factor amino acids 182-250, produced in E.Coli, is a fusion protein with His Tag (4 kDa), having a total molecular mass of 15 kDa.
Recombinant Human Tissue Factor Pathway Inhibitor 2/TFPI-2/PP5/REF-1 (C-6His)
C390-10ug	Novoprotein	10ug	242.4 EUR
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Recombinant Human Tissue Factor Pathway Inhibitor 2/TFPI-2/PP5/REF-1 (C-6His)
C390-1mg	Novoprotein	1mg	2739.6 EUR
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Recombinant Human Tissue Factor Pathway Inhibitor 2/TFPI-2/PP5/REF-1 (C-6His)
C390-500ug	Novoprotein	500ug	1935.6 EUR
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Recombinant Human Tissue Factor Pathway Inhibitor 2/TFPI-2/PP5/REF-1 (C-6His)
C390-50ug	Novoprotein	50ug	595.2 EUR
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Rabbit Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
20-abx155111	Abbexa	8684.40 EUR 4626.00 EUR 1074.00 EUR	10 × 96 tests 5 × 96 tests 96 tests
Rabbit Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
abx574398-96tests	Abbexa	96 tests	990 EUR
Rabbit Tissue factor pathway inhibitor,TFPI ELISA Kit
CN-00639R1	ChemNorm	96T	571.2 EUR
Rabbit Tissue factor pathway inhibitor,TFPI ELISA Kit
CN-00639R2	ChemNorm	48T	391.2 EUR
Rabbit Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
DLR-TFPI-Rb-48T	DL Develop	48T	609.6 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Tissue Factor Pathway Inhibitor (TFPI) in samples from plasma.
Rabbit Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
DLR-TFPI-Rb-96T	DL Develop	96T	793.2 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Tissue Factor Pathway Inhibitor (TFPI) in samples from plasma.
Rabbit Tissue factor pathway inhibitor, TFPI ELISA Kit
CSB-E08263Rb-24T	Cusabio	1 plate of 24 wells	198 EUR
Description: Quantitativesandwich ELISA kit for measuring Rabbit Tissue factor pathway inhibitor, TFPI in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Rabbit Tissue factor pathway inhibitor, TFPI ELISA Kit
1-CSB-E08263Rb	Cusabio	843.60 EUR 5811.60 EUR 3084.00 EUR	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rabbit Tissue factor pathway inhibitor, TFPI in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Rabbit Tissue factor pathway inhibitor,TFPI ELISA Kit
GA-E0208RB-48T	GenAsia Biotech	48T	391.2 EUR
Rabbit Tissue factor pathway inhibitor,TFPI ELISA Kit
GA-E0208RB-96T	GenAsia Biotech	96T	628.8 EUR

Per ogni famiglia ci sono 3 isotipi (α, β, γ) e per ogni isotipo diverse isoforme. Ogni NRR è composto da 6 regioni (A-F). 3 regioni sono importanti: la regione A / B ha una funzione di attivazione trascrizionale indipendente dal ligando, la regione C ospita il dominio di legame del DNA, la regione E ospita il dominio di legame del ligando. Per regolare l’espressione dei geni bersaglio, NRR deve dimerizzare. RXR sono obbligatori nei dimeri (eterodimeri RAR-RXR, omodimeri RXR-RXR). I dimeri si legano a specifiche sequenze di DNA, presenti nei promotori dei geni bersaglio. Quando il ligando, naturale o sintetico, si lega all’RNR, vengono reclutati i coattivatori e vengono attivati ​​i fattori di trascrizione. Nella cellula bersaglio, i retinoidi non utilizzati vengono degradati nei metaboliti polari dagli enzimi del citocromo P450.