Mers Research

Description: It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Description: Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology; 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.

Description: MERS S1 protein, His Tag (S1N-M52H5) is expressed from human 293 cells (HEK293). It contains AA Tyr 18 - Arg 751 (Accession # K0BRG7-1).

Description: It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Description: Since April 2012, cases of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) have been identified in the following countries: Saudi Arabia, Qatar, Jordan, the United Arab Emirates, Oman, Kuwait, Yemen, Lebanon, Iran, Algeria, the United Kingdom, France, Italy, Greece, Germany, the Netherlands, Austria, Tunisia, Egypt, Malaysia, Turkey and the United States of America. Coronaviruses are the cause of the common cold, SARS (severe acute respiratory syndrome) and other severe illnesses with high mortality rates, all are classified into coronavirus family. MERS-CoV is a new type of SARS found in the coronavirus family causing severe pneumonia with sudden and serious respiratory illness with high mortality rates as well. Since January 27th 2015, the WHO has reported 956 human cases, including 351 deaths. More cases of the new coronavirus strain are expected. Like in other coronaviruses, large surface spike glycoprotein is a central structural protein of this virus; it is located above the virion surface to bind and enter into the target cell. Spike protein has 2 domains- S1 and S2. The S1 domain is responsible for cellular tropism and interaction with target cell, while the S2 domain is responsible for membrane fusion. The C-terminal of S1 domain contains a receptor binding domain, and is also a potential target for vaccine development and an antigen for diagnosis.

Description: Forster resonance energy transfer substrate peptide for 3CL Protease (MERS-CoV). Optimal excitation wavelength 485 nm, emission wavelength 528 nm.

Description: Forster resonance energy transfer substrate peptide for 3CL Protease (MERS-CoV). Optimal excitation wavelength 485 nm, emission wavelength 528 nm.

Description: Forster resonance energy transfer substrate peptide for 3CL Protease (MERS-CoV). Optimal excitation wavelength 485 nm, emission wavelength 528 nm.

Description: MERS Nucleocapsid protein, His Tag (NUN-M52H5) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Asp 413 (Accession # K0BVN3-1).

Description: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IKKε (Q14164).

Description: MERS S protein RBD, His Tag (SPD-M52H6) is expressed from human 293 cells (HEK293). It contains AA Glu 367 - Tyr 606 (Accession # K0BRG7-1).

Description: MERS

Description: MERS

Description: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Description: The 3CL Protease (MERS-CoV) Assay Buffer is optimized for use with the 3CL Protease (MERS-CoV) Assay Kit (BPS Bioscience #78023).