Potenziale cumulativo di irritazione e potenziale di sensibilizzazione da contatto della schiuma di tazarotene 0,1% in 2 studi di fase 1 sui cerotti.

Abbiamo eseguito 2 studi di fase 1 sui cerotti per valutare la schiuma di tazarotene allo 0,1% per il potenziale cumulativo di irritazione (studio A) e il potenziale di sensibilizzazione da contatto (studio B). I partecipanti allo studio A hanno indossato cerotti contenenti prodotto di studio attivo, schiuma per veicoli e controlli positivi e negativi per 24 +/- 1 ore per 21 giorni consecutivi. I punteggi di irritazione erano statisticamente più alti con la schiuma di tazarotene allo 0,1% rispetto alla schiuma del veicolo ed entrambi i controlli. Quattordici partecipanti (36%) hanno sperimentato eventi avversi al sito di applicazione (EA) correlati al prodotto; tutti gli eventi avversi sono stati lievi e transitori. I partecipanti allo studio B sono stati esposti al prodotto attivo e alla schiuma del veicolo per una fase di induzione e sfida. A discrezione degli investigatori, ai partecipanti è stata somministrata una nuova sfida per valutare la sensibilizzazione da contatto.

Tre partecipanti hanno dimostrato reazioni di sensibilizzazione discutibili e sono stati sottoposti a una nuova sfida; nessuno dei partecipanti ha mostrato una sensibilizzazione da contatto conclusiva. Tre eventi avversi relativi al sito di applicazione sono stati considerati correlati al prodotto; nessuno degli eventi avversi ha portato all’interruzione dello studio. La schiuma di tazarotene allo 0,1% ha mostrato un potenziale di irritazione ma un basso potenziale di sensibilizzazione da contatto e una tollerabilità e un profilo di sicurezza accettabili. Il lichen striatus (LS) è una dermatosi lineare rara che si osserva principalmente nei bambini dai 4 mesi ai 15 anni di età. Mentre alcune di queste eruzioni sono asintomatiche, altre possono essere piuttosto pruriginose. Negli individui dalla pelle più scura, l’ipopigmentazione post-infiammatoria può essere significativa e può fornire motivo di preoccupazione per i pazienti e / oi loro genitori.

Nella nostra serie di casi di 4 pazienti, abbiamo osservato una rapida risoluzione del LS combinando un retinoide topico con uno steroide topico. A nostra conoscenza, questo è il primo rapporto di successo del trattamento con questo tipo di terapia combinata nella letteratura inglese. I pazienti non solo hanno raggiunto la cosmesi soddisfacente, ma anche la completa risoluzione del loro prurito. L’effetto collaterale più comune del tazarotene topico è l’irritazione localizzata nei siti di trattamento, ma i pazienti in questa particolare serie hanno tollerato bene il trattamento.

Il gene 1 indotto da tazarotene inibisce la crescita delle cellule di cancro del colon HCT116 stimolato dalla prostaglandina E2.

SFONDO
Il gene 1 indotto dal tazarotene (TIG1) è un presunto gene oncosoppressore. Abbiamo recentemente dimostrato che le isoforme TIG1A e TIG1B inibiscono la crescita cellulare e inducono l’espressione della chinasi 5 del recettore accoppiato a proteine ​​G (GRK5) nelle cellule di cancro del colon. Poiché la segnalazione elevata della prostaglandina E2 (PGE2) gioca un ruolo significativo nella carcinogenesi del colon-retto, l’obiettivo di questo studio era di esplorare l’effetto di TIG1 sulla proliferazione cellulare indotta da PGE2 e sulla segnalazione nelle cellule di cancro del colon.

METODI
Sono state utilizzate cellule HCT116 e cellule stabili TIG1A e TIG1B create da cellule di cancro al colon HCT116 utilizzando il sistema GeneSwitch. L’espressione dell’isoforma TIG1 è stata indotta dal trattamento con mifepristone in cellule stabili. La crescita cellulare è stata determinata utilizzando il test di proliferazione cellulare WST-1. L’attivazione della β-catenina / TCF e dell’adenosina monofosfato ciclico (cAMP) / CREB è stata determinata mediante saggi reporter della luciferasi. L’espressione e la distribuzione subcellulare della β-catenina sono state analizzate utilizzando Western blot e microscopio confocale. I livelli di cAMP sono stati misurati utilizzando un dosaggio immunoenzimatico. L’interferenza dell’RNA è stata utilizzata per esaminare gli effetti dei cambiamenti mediati da TIG1 e GRK5.

RISULTATI
La crescita cellulare stimolata da PGE2 è stata ridotta nelle cellule HCT116 inducibili TIG1A e TIG1B stabili. L’espressione di GRK5 è stata sovraregolata dalle isoforme TIG1A e TIG1B e la sua espressione ha soppresso la crescita delle cellule HCT116 stimolata da PGE2. L’espressione di GRK5, TIG1A e TIG1B ha inibito in modo significativo i reporter e il cAMP della via di segnalazione stimolata da PGE2 β-catenina / TCF e cAMP. Inoltre, la localizzazione nucleare della β-catenina stimolata da PGE2 è stata inibita dall’espressione di TIG1A e TIG1B, che è stata migliorata dagli siRNA sia TIG1 che GRK5.

CONCLUSIONITIG1 ha soppresso le vie di segnalazione Wnt e cAMP stimolate da PGE2 nelle cellule di cancro del colon attraverso GRK5.

Revisione basata sull’evidenza: terapia di combinazione fissa e retinoidi topici nel trattamento dell’acne.

I prodotti topici a combinazione fissa e la monoterapia topica con retinoidi sono trattamenti di prima linea stabiliti per l’acne vulgaris da lieve a moderata, ma mancano dati comparativi adeguati. La seguente revisione basata sull’evidenza affronta la domanda: “Nei pazienti con acne da lieve a moderata, i prodotti topici a combinazione fissa oi retinoidi topici sono una scelta più efficace nel ridurre le lesioni non infiammatorie, infiammatorie e totali dopo 12 settimane di trattamento?” Per identificare studi rilevanti, è stata eseguita una ricerca PubMed utilizzando “acne” e termini di ricerca per adapalene, tretinoina, tazarotene, perossido di benzoile, clindamicina o eritromicina. Quarantadue studi dal gennaio 1991 al novembre 2009 sono stati inclusi.

Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx103329	Abbexa	510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx104947	Abbexa	376.80 EUR 159.60 EUR 994.80 EUR 526.80 EUR 326.40 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx174804	Abbexa	1011.60 EUR 526.80 EUR	1 mg 200 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx116110	Abbexa	878.40 EUR 477.60 EUR	150 ul 50 ul
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx129517	Abbexa	493.20 EUR 159.60 EUR 1362.00 EUR 661.20 EUR 376.80 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx132084	Abbexa	360.00 EUR 844.80 EUR 427.20 EUR 184.80 EUR 292.80 EUR	100 ug 1 mg 200 ug 20 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx132085	Abbexa	393.60 EUR 1011.60 EUR 526.80 EUR 184.80 EUR 309.60 EUR	100 ug 1 mg 200 ug 20 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx132086	Abbexa	360.00 EUR 844.80 EUR 427.20 EUR 184.80 EUR 292.80 EUR	100 ug 1 mg 200 ug 20 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx323593	Abbexa	376.80 EUR 292.80 EUR	100 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx433382-200ul	Abbexa	200 ul	460.8 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx001368	Abbexa	493.20 EUR 710.40 EUR 218.40 EUR 376.80 EUR	100 ul 200 ul 20 ul 50 ul
Human Tissue factor pathway inhibitor (TFPI)
1-CSB-EP023437HU	Cusabio	456.00 EUR 256.80 EUR 1570.80 EUR 672.00 EUR 1047.60 EUR 314.40 EUR	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Tissue factor pathway inhibitor(TFPI),partial expressed in E.coli
Rabbit Tissue factor pathway inhibitor (TFPI)
1-CSB-BP023437RB	Cusabio	1008.00 EUR 398.40 EUR 2604.00 EUR 1362.00 EUR 1894.80 EUR 564.00 EUR	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rabbit Tissue factor pathway inhibitor(TFPI) expressed in Baculovirus
Rabbit Tissue factor pathway inhibitor (TFPI)
1-CSB-YP023437RB	Cusabio	814.80 EUR 402.00 EUR 2606.40 EUR 1261.20 EUR 1730.40 EUR 522.00 EUR	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rabbit Tissue factor pathway inhibitor(TFPI) expressed in Yeast
Rabbit Tissue factor pathway inhibitor (TFPI)
1-CSB-EP023437RB	Cusabio	733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40 EUR	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rabbit Tissue factor pathway inhibitor(TFPI) expressed in E.coli
Rabbit Tissue factor pathway inhibitor (TFPI)
1-CSB-MP023437RB	Cusabio	466.80 EUR 1672.80 EUR 675.60 EUR 1230.00 EUR	100ug 1MG 200ug 500ug
Description: Recombinant Rabbit Tissue factor pathway inhibitor(TFPI) expressed in Mammalian cell
Tissue Factor Pathway Inhibitor (TFPI) Protein
20-abx261170	Abbexa	4101.60 EUR 393.60 EUR 276.00 EUR	1 mg 20 ug 5 ug
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Hu01	Cloud-Clone	571.58 EUR 276.00 EUR 1813.44 EUR 684.48 EUR 1248.96 EUR 458.40 EUR 4353.60 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Hu02	Cloud-Clone	571.58 EUR 276.00 EUR 1813.44 EUR 684.48 EUR 1248.96 EUR 458.40 EUR 4353.60 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Hu03	Cloud-Clone	571.58 EUR 276.00 EUR 1813.44 EUR 684.48 EUR 1248.96 EUR 458.40 EUR 4353.60 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Mu01	Cloud-Clone	496.32 EUR 256.80 EUR 1531.20 EUR 590.40 EUR 1060.80 EUR 408.00 EUR 3648.00 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Ra01	Cloud-Clone	421.06 EUR 236.40 EUR 1248.96 EUR 496.32 EUR 872.64 EUR 357.60 EUR 2942.40 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Rb01	Cloud-Clone	614.59 EUR 288.00 EUR 1974.72 EUR 738.24 EUR 1356.48 EUR 487.20 EUR 4756.80 EUR	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rabbit Tissue Factor Pathway Inhibitor expressed in: E.coli
Tissue Factor Pathway Inhibitor (TFPI) Antibody Pair
20-abx370061	Abbexa	2047.20 EUR 1312.80 EUR	10 × 96 tests 5 × 96 tests
Tissue Factor Pathway Inhibitor (TFPI) Antibody Pair
20-abx370161	Abbexa	1946.40 EUR 1245.60 EUR	10 × 96 tests 5 × 96 tests
Tissue Factor Pathway Inhibitor (TFPI) Antibody Pair
20-abx370357	Abbexa	1412.40 EUR 927.60 EUR	10 × 96 tests 5 × 96 tests
Tissue Factor Pathway Inhibitor (TFPI) Antibody Pair
20-abx370374	Abbexa	2047.20 EUR 1312.80 EUR	10 × 96 tests 5 × 96 tests
Tissue Factor Pathway Inhibitor (TFPI) Antibody (FITC)
20-abx274012	Abbexa	543.60 EUR 292.80 EUR 1579.20 EUR 760.80 EUR 410.40 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody (FITC)
20-abx274146	Abbexa	560.40 EUR 292.80 EUR 1663.20 EUR 777.60 EUR 427.20 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Human Tissue Factor Pathway Inhibitor (TFPI) Antibody
11621-05011	AssayPro	150 ug	260.4 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody (Biotin)
20-abx271976	Abbexa	393.60 EUR 260.40 EUR 1078.80 EUR 543.60 EUR 343.20 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody (Biotin)
20-abx272693	Abbexa	510.00 EUR 276.00 EUR 1462.80 EUR 710.40 EUR 393.60 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody (Biotin)
20-abx273169	Abbexa	543.60 EUR 292.80 EUR 1545.60 EUR 744.00 EUR 410.40 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody (Biotin)
20-abx274501	Abbexa	376.80 EUR 243.60 EUR 910.80 EUR 493.20 EUR 326.40 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Rat Tissue Factor Pathway Inhibitor (TFPI) Protein
20-abx069319	Abbexa	594.00 EUR 292.80 EUR 1696.80 EUR 693.60 EUR 427.20 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Human Tissue Factor Pathway Inhibitor (TFPI) Protein
20-abx069318	Abbexa	794.40 EUR 326.40 EUR 2448.00 EUR 944.40 EUR 577.20 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Human Tissue Factor Pathway Inhibitor (TFPI) Protein
20-abx069321	Abbexa	794.40 EUR 326.40 EUR 2448.00 EUR 944.40 EUR 577.20 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Human Tissue Factor Pathway Inhibitor (TFPI) Protein
20-abx069322	Abbexa	794.40 EUR 326.40 EUR 2448.00 EUR 944.40 EUR 577.20 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Mouse Tissue Factor Pathway Inhibitor (TFPI) Protein
20-abx167190	Abbexa	693.60 EUR 309.60 EUR 2064.00 EUR 828.00 EUR 510.00 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Rabbit Tissue Factor Pathway Inhibitor (TFPI) Protein
20-abx069320	Abbexa	861.60 EUR 343.20 EUR 2665.20 EUR 1028.40 EUR 610.80 EUR	100 ug 10 ug 1 mg 200 ug 50 ug
Rat Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
abx195579-96tests	Abbexa	96 tests	990 EUR
Rat Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
20-abx491438	Abbexa	10282.80 EUR 5472.00 EUR 1262.40 EUR	10 × 96 tests 5 × 96 tests 96 tests
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
abx256044-96tests	Abbexa	96 tests	801.6 EUR
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
abx573759-96tests	Abbexa	96 tests	801.6 EUR
Pig Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
abx360618-96tests	Abbexa	96 tests	990 EUR
Rat Tissue factor pathway inhibitor,TFPI ELISA Kit
CN-01880R1	ChemNorm	96T	542.4 EUR
Rat Tissue factor pathway inhibitor,TFPI ELISA Kit
CN-01880R2	ChemNorm	48T	362.4 EUR
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
DLR-TFPI-Ra-48T	DL Develop	48T	609.6 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Rat Tissue Factor Pathway Inhibitor (TFPI) in samples from plasma, urine, tissue homogenates, cell culture supernates or other biological fluids.
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
DLR-TFPI-Ra-96T	DL Develop	96T	793.2 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Rat Tissue Factor Pathway Inhibitor (TFPI) in samples from plasma, urine, tissue homogenates, cell culture supernates or other biological fluids.
Rat Tissue factor pathway inhibitor, TFPI ELISA Kit
CSB-E08261r-24T	Cusabio	1 plate of 24 wells	198 EUR
Description: Quantitativesandwich ELISA kit for measuring Rat Tissue factor pathway inhibitor, TFPI in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Rat Tissue factor pathway inhibitor, TFPI ELISA Kit
1-CSB-E08261r	Cusabio	1160.40 EUR 7110.00 EUR 3760.80 EUR	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Tissue factor pathway inhibitor, TFPI in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
20-abx156138	Abbexa	8684.40 EUR 4626.00 EUR 1074.00 EUR	10 × 96 tests 5 × 96 tests 96 tests
Rat Tissue factor pathway inhibitor(TFPI)ELISA Kit
GA-E0803RT-48T	GenAsia Biotech	48T	380.4 EUR
Rat Tissue factor pathway inhibitor(TFPI)ELISA Kit
GA-E0803RT-96T	GenAsia Biotech	96T	595.2 EUR
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RDR-TFPI-Ra-48Tests	Reddot Biotech	48 Tests	640.8 EUR
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RDR-TFPI-Ra-96Tests	Reddot Biotech	96 Tests	890.4 EUR
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RD-TFPI-Ra-48Tests	Reddot Biotech	48 Tests	613.2 EUR
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RD-TFPI-Ra-96Tests	Reddot Biotech	96 Tests	850.8 EUR
Rat Tissue factor pathway inhibitor(TFPI)ELISA Kit
QY-E10849	Qayee Biotechnology	96T	433.2 EUR
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
SEA394Ra-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	5552.14 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Tissue Factor Pathway Inhibitor (TFPI) in plasma, urine, tissue homogenates, cell culture supernates and other biological fluids.
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
SEA394Ra-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	562.42 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Tissue Factor Pathway Inhibitor (TFPI) in plasma, urine, tissue homogenates, cell culture supernates and other biological fluids.
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
SEA394Ra-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	752.02 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Tissue Factor Pathway Inhibitor (TFPI) in plasma, urine, tissue homogenates, cell culture supernates and other biological fluids.
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
SEA394Ra-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	3024.07 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Tissue Factor Pathway Inhibitor (TFPI) in plasma, urine, tissue homogenates, cell culture supernates and other biological fluids.
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
4-SEA394Ra	Cloud-Clone	5612.40 EUR 2965.20 EUR 752.40 EUR	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Tissue Factor Pathway Inhibitor (TFPI) in samples from plasma, urine, tissue homogenates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RDR-TFPI-Ra-48T	Reddot Biotech	48T	465.47 EUR
Description: plasma, urine, tissue homogenates, cell culture supernatants and other biological fluids.
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RDR-TFPI-Ra-96T	Reddot Biotech	96T	664.97 EUR
Description: plasma, urine, tissue homogenates, cell culture supernatants and other biological fluids.
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RD-TFPI-Ra-48T	Reddot Biotech	48T	443.3 EUR
Description: plasma, urine, tissue homogenates, cell culture supernatants and other biological fluids.
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RD-TFPI-Ra-96T	Reddot Biotech	96T	633.3 EUR
Description: plasma, urine, tissue homogenates, cell culture supernatants and other biological fluids.
Rat Tissue factor pathway inhibitor,TFPI ELISA Kit
YLA1126RA-48T	Shanghai YL Biotech	48T	465 EUR
Rat Tissue factor pathway inhibitor,TFPI ELISA Kit
YLA1126RA-96T	Shanghai YL Biotech	96T	600 EUR
Human Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
20-abx190101	Abbexa	9493.20 EUR 5058.00 EUR 1167.60 EUR	10 × 96 tests 5 × 96 tests 96 tests
Mouse Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
20-abx190450	Abbexa	9567.60 EUR 5095.20 EUR 1177.20 EUR	10 × 96 tests 5 × 96 tests 96 tests
Human Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
abx195577-96tests	Abbexa	96 tests	990 EUR
Mouse Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
abx195578-96tests	Abbexa	96 tests	990 EUR
Human Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
20-abx490680	Abbexa	8853.60 EUR 4719.60 EUR 1093.20 EUR	10 × 96 tests 5 × 96 tests 96 tests
Human Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
20-abx496351	Abbexa	8853.60 EUR 4719.60 EUR 1093.20 EUR	10 × 96 tests 5 × 96 tests 96 tests
Human Tissue Factor Pathway Inhibitor (TFPI)CLIA Kit
SCA394Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	6777.36 EUR
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Tissue Factor Pathway Inhibitor (TFPI) in Plasma, urine, cell culture supernates and other biological fluids.
Human Tissue Factor Pathway Inhibitor (TFPI)CLIA Kit
SCA394Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	663.31 EUR
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Tissue Factor Pathway Inhibitor (TFPI) in Plasma, urine, cell culture supernates and other biological fluids.
Human Tissue Factor Pathway Inhibitor (TFPI)CLIA Kit
SCA394Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	896.16 EUR
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Tissue Factor Pathway Inhibitor (TFPI) in Plasma, urine, cell culture supernates and other biological fluids.
Human Tissue Factor Pathway Inhibitor (TFPI)CLIA Kit
SCA394Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	3672.72 EUR
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Tissue Factor Pathway Inhibitor (TFPI) in Plasma, urine, cell culture supernates and other biological fluids.
Human Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
4-SCA394Hu	Cloud-Clone	6837.60 EUR 3673.20 EUR 896.40 EUR	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Tissue Factor Pathway Inhibitor (TFPI)Plasma, urine, cell culture supernates and other biological fluids
Mouse Tissue Factor Pathway Inhibitor (TFPI)CLIA Kit
SCA394Mu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	6965.86 EUR
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Tissue Factor Pathway Inhibitor (TFPI) in Plasma, urine, cell culture supernates and other biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI)CLIA Kit
SCA394Mu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	678.84 EUR
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Tissue Factor Pathway Inhibitor (TFPI) in Plasma, urine, cell culture supernates and other biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI)CLIA Kit
SCA394Mu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	918.34 EUR
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Tissue Factor Pathway Inhibitor (TFPI) in Plasma, urine, cell culture supernates and other biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI)CLIA Kit
SCA394Mu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	3772.51 EUR
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Tissue Factor Pathway Inhibitor (TFPI) in Plasma, urine, cell culture supernates and other biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
4-SCA394Mu	Cloud-Clone	7026.00 EUR 3772.80 EUR 919.20 EUR	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Mouse Tissue Factor Pathway Inhibitor (TFPI)Plasma, urine, cell culture supernates and other biological fluids
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
20-abx258352	Abbexa	6618.00 EUR 3536.40 EUR 830.40 EUR	10 × 96 tests 5 × 96 tests 96 tests
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
abx254457-96tests	Abbexa	96 tests	801.6 EUR
Horse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
abx257471-96tests	Abbexa	96 tests	1177.2 EUR
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
abx252213-96tests	Abbexa	96 tests	764.4 EUR
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
20-abx154740	Abbexa	7970.40 EUR 4250.40 EUR 990.00 EUR	10 × 96 tests 5 × 96 tests 96 tests
Sheep Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
abx364322-96tests	Abbexa	96 tests	1111.2 EUR
Human Tissue factor pathway inhibitor,TFPI ELISA Kit
201-12-1189	SunredBio	96 tests	528 EUR
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
20-abx054160	Abbexa	7970.40 EUR 4250.40 EUR 990.00 EUR	10 × 96 tests 5 × 96 tests 96 tests
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
abx570059-96tests	Abbexa	96 tests	764.4 EUR
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
20-abx585042	Abbexa	6618.00 EUR 3536.40 EUR 830.40 EUR	10 × 96 tests 5 × 96 tests 96 tests
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
abx576269-96tests	Abbexa	96 tests	801.6 EUR
Rabbit Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
20-abx491439	Abbexa	10282.80 EUR 5472.00 EUR 1262.40 EUR	10 × 96 tests 5 × 96 tests 96 tests
Human Tissue factor pathway inhibitor,TFPI ELISA Kit
CN-03357H1	ChemNorm	96T	544.8 EUR
Human Tissue factor pathway inhibitor,TFPI ELISA Kit
CN-03357H2	ChemNorm	48T	363.6 EUR
Mouse Tissue factor pathway inhibitor,TFPI ELISA Kit
CN-02305M1	ChemNorm	96T	558 EUR
Mouse Tissue factor pathway inhibitor,TFPI ELISA Kit
CN-02305M2	ChemNorm	48T	378 EUR
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
DLR-TFPI-Hu-48T	DL Develop	48T	456 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Human Tissue Factor Pathway Inhibitor (TFPI) in samples from plasma, urine, tissue homogenates, cell culture supernates or other biological fluids.
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
DLR-TFPI-Hu-96T	DL Develop	96T	582 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Human Tissue Factor Pathway Inhibitor (TFPI) in samples from plasma, urine, tissue homogenates, cell culture supernates or other biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
DLR-TFPI-Mu-48T	DL Develop	48T	586.8 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Tissue Factor Pathway Inhibitor (TFPI) in samples from plasma, urine, cell culture supernates or other biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
DLR-TFPI-Mu-96T	DL Develop	96T	762 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Tissue Factor Pathway Inhibitor (TFPI) in samples from plasma, urine, cell culture supernates or other biological fluids.
Human Tissue factor pathway inhibitor, TFPI ELISA Kit
CSB-E08260h-24T	Cusabio	1 plate of 24 wells	198 EUR
Description: Quantitative sandwich ELISA kit for measuring Human Tissue factor pathway inhibitor, TFPI in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Human Tissue factor pathway inhibitor, TFPI ELISA Kit
1-CSB-E08260h	Cusabio	667.20 EUR 4634.40 EUR 2472.00 EUR	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Human Tissue factor pathway inhibitor, TFPI in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Mouse Tissue factor pathway inhibitor, TFPI ELISA Kit
CSB-E08262m-24T	Cusabio	1 plate of 24 wells	198 EUR
Description: Quantitativesandwich ELISA kit for measuring Mouse Tissue factor pathway inhibitor, TFPI in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Mouse Tissue factor pathway inhibitor, TFPI ELISA Kit
1-CSB-E08262m	Cusabio	843.60 EUR 5811.60 EUR 3084.00 EUR	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Tissue factor pathway inhibitor, TFPI in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
20-abx153262	Abbexa	6373.20 EUR 3404.40 EUR 801.60 EUR	10 × 96 tests 5 × 96 tests 96 tests
Human Tissue factor pathway inhibitor(TFPI)ELISA Kit
GA-E1205HM-48T	GenAsia Biotech	48T	346.8 EUR
Human Tissue factor pathway inhibitor(TFPI)ELISA Kit
GA-E1205HM-96T	GenAsia Biotech	96T	559.2 EUR
Mouse Tissue factor pathway inhibitor(TFPI)ELISA Kit
GA-E0281MS-48T	GenAsia Biotech	48T	403.2 EUR
Mouse Tissue factor pathway inhibitor(TFPI)ELISA Kit
GA-E0281MS-96T	GenAsia Biotech	96T	640.8 EUR
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RDR-TFPI-Hu-48Tests	Reddot Biotech	48 Tests	459.6 EUR
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RDR-TFPI-Hu-96Tests	Reddot Biotech	96 Tests	630 EUR
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RDR-TFPI-Mu-48Tests	Reddot Biotech	48 Tests	613.2 EUR
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RDR-TFPI-Mu-96Tests	Reddot Biotech	96 Tests	850.8 EUR
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RD-TFPI-Hu-48Tests	Reddot Biotech	48 Tests	440.4 EUR
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RD-TFPI-Hu-96Tests	Reddot Biotech	96 Tests	602.4 EUR
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RD-TFPI-Mu-48Tests	Reddot Biotech	48 Tests	586.8 EUR
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RD-TFPI-Mu-96Tests	Reddot Biotech	96 Tests	812.4 EUR
Mouse Tissue factor pathway inhibitor(TFPI)ELISA Kit
QY-E21471	Qayee Biotechnology	96T	433.2 EUR
Human Tissue factor pathway inhibitor(TFPI)ELISA Kit
QY-E00007	Qayee Biotechnology	96T	433.2 EUR
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
SEA394Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	3682.88 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tissue Factor Pathway Inhibitor (TFPI) in plasma, urine, tissue homogenates, cell culture supernates and other biological fluids.
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
SEA394Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	408.47 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tissue Factor Pathway Inhibitor (TFPI) in plasma, urine, tissue homogenates, cell culture supernates and other biological fluids.
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
SEA394Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	532.1 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tissue Factor Pathway Inhibitor (TFPI) in plasma, urine, tissue homogenates, cell culture supernates and other biological fluids.
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
SEA394Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	2034.47 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tissue Factor Pathway Inhibitor (TFPI) in plasma, urine, tissue homogenates, cell culture supernates and other biological fluids.
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
4-SEA394Hu	Cloud-Clone	3744.00 EUR 1975.20 EUR 532.80 EUR	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tissue Factor Pathway Inhibitor (TFPI) in samples from plasma, urine, tissue homogenates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
SEA394Mu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	5269.39 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Tissue Factor Pathway Inhibitor (TFPI) in Plasma, urine, cell culture supernates and other biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
SEA394Mu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	539.12 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Tissue Factor Pathway Inhibitor (TFPI) in Plasma, urine, cell culture supernates and other biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
SEA394Mu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	718.75 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Tissue Factor Pathway Inhibitor (TFPI) in Plasma, urine, cell culture supernates and other biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
SEA394Mu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	2874.38 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Tissue Factor Pathway Inhibitor (TFPI) in Plasma, urine, cell culture supernates and other biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
4-SEA394Mu	Cloud-Clone	5330.40 EUR 2815.20 EUR 718.80 EUR	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Tissue Factor Pathway Inhibitor (TFPI) in samples from Plasma, urine, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.
Human Tissue factor pathway inhibitor,TFPI ELISA Kit
YLA0462HU-48T	Shanghai YL Biotech	48T	435 EUR
Human Tissue factor pathway inhibitor,TFPI ELISA Kit
YLA0462HU-96T	Shanghai YL Biotech	96T	562.5 EUR
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RDR-TFPI-Hu-48T	Reddot Biotech	48T	319.73 EUR
Description: plasma, urine, tissue homogenates, cell culture supernatants and other biological fluids.
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RDR-TFPI-Hu-96T	Reddot Biotech	96T	456.75 EUR
Description: plasma, urine, tissue homogenates, cell culture supernatants and other biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RDR-TFPI-Mu-48T	Reddot Biotech	48T	443.42 EUR
Description: plasma, urine, cell culture supernatants and other biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RDR-TFPI-Mu-96T	Reddot Biotech	96T	633.47 EUR
Description: plasma, urine, cell culture supernatants and other biological fluids.
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RD-TFPI-Hu-48T	Reddot Biotech	48T	304.5 EUR
Description: plasma, urine, tissue homogenates, cell culture supernatants and other biological fluids.
Human Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RD-TFPI-Hu-96T	Reddot Biotech	96T	435 EUR
Description: plasma, urine, tissue homogenates, cell culture supernatants and other biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RD-TFPI-Mu-48T	Reddot Biotech	48T	422.3 EUR
Description: plasma, urine, cell culture supernatants and other biological fluids.
Mouse Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
RD-TFPI-Mu-96T	Reddot Biotech	96T	603.3 EUR
Description: plasma, urine, cell culture supernatants and other biological fluids.
Mouse Tissue factor pathway inhibitor,TFPI ELISA Kit
YLA0745MO-48T	Shanghai YL Biotech	48T	465 EUR
Mouse Tissue factor pathway inhibitor,TFPI ELISA Kit
YLA0745MO-96T	Shanghai YL Biotech	96T	600 EUR
Rabbit Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
20-abx155111	Abbexa	8684.40 EUR 4626.00 EUR 1074.00 EUR	10 × 96 tests 5 × 96 tests 96 tests
Rabbit Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
abx574398-96tests	Abbexa	96 tests	990 EUR
Monkey Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
abx353358-96tests	Abbexa	96 tests	990 EUR
Monkey Tissue factor pathway inhibitor(TFPI) ELISA kit
CSB-EL023437RH-24T	Cusabio	1 plate of 24 wells	198 EUR
Description: Quantitativesandwich ELISA kit for measuring Monkey Tissue factor pathway inhibitor (TFPI) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Monkey Tissue factor pathway inhibitor(TFPI) ELISA kit
1-CSB-EL023437RH	Cusabio	1080.00 EUR 6571.20 EUR 3480.00 EUR	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Monkey Tissue factor pathway inhibitor(TFPI) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Rabbit Tissue factor pathway inhibitor,TFPI ELISA Kit
CN-00639R1	ChemNorm	96T	571.2 EUR
Rabbit Tissue factor pathway inhibitor,TFPI ELISA Kit
CN-00639R2	ChemNorm	48T	391.2 EUR
Rabbit Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
DLR-TFPI-Rb-48T	DL Develop	48T	609.6 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Tissue Factor Pathway Inhibitor (TFPI) in samples from plasma.
Rabbit Tissue Factor Pathway Inhibitor (TFPI) ELISA Kit
DLR-TFPI-Rb-96T	DL Develop	96T	793.2 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Tissue Factor Pathway Inhibitor (TFPI) in samples from plasma.

Gli studi sono stati valutati utilizzando la tassonomia della forza della raccomandazione e tutti tranne sette hanno ricevuto il più alto livello di evidenza. Per valutare l’efficacia, è stato effettuato un confronto fianco a fianco utilizzando la riduzione del conteggio delle lesioni da acne alla settimana 12 per i gruppi di studio trattati con terapia di associazione fissa o monoterapia con retinoidi. Ventinove studi contenenti dati di efficacia rilevanti per la terapia di associazione fissa e la monoterapia con retinoidi sono riassunti qui. Nove studi hanno confrontato la terapia di associazione fissa con la monoterapia con retinoidi; in otto di questi studi, la terapia di combinazione fissa è stata significativamente più efficace nel ridurre il numero di lesioni da acne. Questa revisione basata sull’evidenza analizza le prove cliniche fino ad oggi per queste terapie per fornire una guida nella determinazione del trattamento appropriato per i pazienti con acne lieve-moderata.