Potenziale cumulativo di irritazione e potenziale di sensibilizzazione da contatto della schiuma di tazarotene 0,1% in 2 studi di fase 1 sui cerotti.

Abbiamo eseguito 2 studi di fase 1 sui cerotti per valutare la schiuma di tazarotene allo 0,1% per il potenziale cumulativo di irritazione (studio A) e il potenziale di sensibilizzazione da contatto (studio B). I partecipanti allo studio A hanno indossato cerotti contenenti prodotto di studio attivo, schiuma per veicoli e controlli positivi e negativi per 24 +/- 1 ore per 21 giorni consecutivi. I punteggi di irritazione erano statisticamente più alti con la schiuma di tazarotene allo 0,1% rispetto alla schiuma del veicolo ed entrambi i controlli. Quattordici partecipanti (36%) hanno sperimentato eventi avversi al sito di applicazione (EA) correlati al prodotto; tutti gli eventi avversi sono stati lievi e transitori. I partecipanti allo studio B sono stati esposti al prodotto attivo e alla schiuma del veicolo per una fase di induzione e sfida. A discrezione degli investigatori, ai partecipanti è stata somministrata una nuova sfida per valutare la sensibilizzazione da contatto.

Tre partecipanti hanno dimostrato reazioni di sensibilizzazione discutibili e sono stati sottoposti a una nuova sfida; nessuno dei partecipanti ha mostrato una sensibilizzazione da contatto conclusiva. Tre eventi avversi relativi al sito di applicazione sono stati considerati correlati al prodotto; nessuno degli eventi avversi ha portato all’interruzione dello studio. La schiuma di tazarotene allo 0,1% ha mostrato un potenziale di irritazione ma un basso potenziale di sensibilizzazione da contatto e una tollerabilità e un profilo di sicurezza accettabili. Il lichen striatus (LS) è una dermatosi lineare rara che si osserva principalmente nei bambini dai 4 mesi ai 15 anni di età. Mentre alcune di queste eruzioni sono asintomatiche, altre possono essere piuttosto pruriginose. Negli individui dalla pelle più scura, l’ipopigmentazione post-infiammatoria può essere significativa e può fornire motivo di preoccupazione per i pazienti e / oi loro genitori.

Nella nostra serie di casi di 4 pazienti, abbiamo osservato una rapida risoluzione del LS combinando un retinoide topico con uno steroide topico. A nostra conoscenza, questo è il primo rapporto di successo del trattamento con questo tipo di terapia combinata nella letteratura inglese. I pazienti non solo hanno raggiunto la cosmesi soddisfacente, ma anche la completa risoluzione del loro prurito. L’effetto collaterale più comune del tazarotene topico è l’irritazione localizzata nei siti di trattamento, ma i pazienti in questa particolare serie hanno tollerato bene il trattamento.

Il gene 1 indotto da tazarotene inibisce la crescita delle cellule di cancro del colon HCT116 stimolato dalla prostaglandina E2.

SFONDO
Il gene 1 indotto dal tazarotene (TIG1) è un presunto gene oncosoppressore. Abbiamo recentemente dimostrato che le isoforme TIG1A e TIG1B inibiscono la crescita cellulare e inducono l’espressione della chinasi 5 del recettore accoppiato a proteine ​​G (GRK5) nelle cellule di cancro del colon. Poiché la segnalazione elevata della prostaglandina E2 (PGE2) gioca un ruolo significativo nella carcinogenesi del colon-retto, l’obiettivo di questo studio era di esplorare l’effetto di TIG1 sulla proliferazione cellulare indotta da PGE2 e sulla segnalazione nelle cellule di cancro del colon.

METODI
Sono state utilizzate cellule HCT116 e cellule stabili TIG1A e TIG1B create da cellule di cancro al colon HCT116 utilizzando il sistema GeneSwitch. L’espressione dell’isoforma TIG1 è stata indotta dal trattamento con mifepristone in cellule stabili. La crescita cellulare è stata determinata utilizzando il test di proliferazione cellulare WST-1. L’attivazione della β-catenina / TCF e dell’adenosina monofosfato ciclico (cAMP) / CREB è stata determinata mediante saggi reporter della luciferasi. L’espressione e la distribuzione subcellulare della β-catenina sono state analizzate utilizzando Western blot e microscopio confocale. I livelli di cAMP sono stati misurati utilizzando un dosaggio immunoenzimatico. L’interferenza dell’RNA è stata utilizzata per esaminare gli effetti dei cambiamenti mediati da TIG1 e GRK5.

RISULTATI
La crescita cellulare stimolata da PGE2 è stata ridotta nelle cellule HCT116 inducibili TIG1A e TIG1B stabili. L’espressione di GRK5 è stata sovraregolata dalle isoforme TIG1A e TIG1B e la sua espressione ha soppresso la crescita delle cellule HCT116 stimolata da PGE2. L’espressione di GRK5, TIG1A e TIG1B ha inibito in modo significativo i reporter e il cAMP della via di segnalazione stimolata da PGE2 β-catenina / TCF e cAMP. Inoltre, la localizzazione nucleare della β-catenina stimolata da PGE2 è stata inibita dall’espressione di TIG1A e TIG1B, che è stata migliorata dagli siRNA sia TIG1 che GRK5.

CONCLUSIONITIG1 ha soppresso le vie di segnalazione Wnt e cAMP stimolate da PGE2 nelle cellule di cancro del colon attraverso GRK5.

Revisione basata sull’evidenza: terapia di combinazione fissa e retinoidi topici nel trattamento dell’acne.

I prodotti topici a combinazione fissa e la monoterapia topica con retinoidi sono trattamenti di prima linea stabiliti per l’acne vulgaris da lieve a moderata, ma mancano dati comparativi adeguati. La seguente revisione basata sull’evidenza affronta la domanda: “Nei pazienti con acne da lieve a moderata, i prodotti topici a combinazione fissa oi retinoidi topici sono una scelta più efficace nel ridurre le lesioni non infiammatorie, infiammatorie e totali dopo 12 settimane di trattamento?” Per identificare studi rilevanti, è stata eseguita una ricerca PubMed utilizzando “acne” e termini di ricerca per adapalene, tretinoina, tazarotene, perossido di benzoile, clindamicina o eritromicina. Quarantadue studi dal gennaio 1991 al novembre 2009 sono stati inclusi.

Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx103325	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx103326	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx103328	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx103329	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx104947	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx129517	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx132084	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx132085	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx132086	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx116110	Abbexa	Ask for price Ask for price	150 ul 50 ul
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx001368	Abbexa	Ask for price Ask for price Ask for price Ask for price	100 ul 200 ul 20 ul 50 ul
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx174804	Abbexa	Ask for price Ask for price	1 mg 200 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx433382-200ul	Abbexa	200 ul	460.8 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx238634-100ug	Abbexa	100 ug	661.2 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
20-abx323593	Abbexa	Ask for price Ask for price	100 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx116110-100g	Abbexa	100 µg	Ask for price
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx116110-10g	Abbexa	10 µg	612.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx116110-200g	Abbexa	200 µg	Ask for price
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx129517-100l	Abbexa	100 µl	262.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx129517-1ml	Abbexa	1 ml	687.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx129517-200l	Abbexa	200 µl	325 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx174804-25mg	Abbexa	25 mg	Ask for price
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx174804-5mg	Abbexa	5 mg	775 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx238634-100l	Abbexa	100 µl	Ask for price
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx238634-50l	Abbexa	50 µl	350 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx132084-100tests	Abbexa	100 tests	237.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx132085-01mg	Abbexa	0.1 mg	275 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx132086-01mg	Abbexa	0.1 mg	237.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx349963-96tests	Abbexa	96 tests	287.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx433382-100g	Abbexa	100 µg	387.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx323593-100g	Abbexa	100 µg	250 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx323593-50g	Abbexa	50 µg	187.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx001368-100l	Abbexa	100 µl	400 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx001368-20l	Abbexa	20 µl	175 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx001368-50l	Abbexa	50 µl	275 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx104947-100g	Abbexa	100 µg	475 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx104947-20g	Abbexa	20 µg	212.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx104947-50g	Abbexa	50 µg	250 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx103325-100g	Abbexa	100 µg	475 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx103325-20g	Abbexa	20 µg	212.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx103325-50g	Abbexa	50 µg	250 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx103326-100g	Abbexa	100 µg	475 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx103326-20g	Abbexa	20 µg	212.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx103326-50g	Abbexa	50 µg	250 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx103328-100g	Abbexa	100 µg	725 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx103328-20g	Abbexa	20 µg	262.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx103328-50g	Abbexa	50 µg	337.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx103329-100g	Abbexa	100 µg	725 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx103329-20g	Abbexa	20 µg	262.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody
abx103329-50g	Abbexa	50 µg	337.5 EUR
Human Tissue factor pathway inhibitor (TFPI)
1-CSB-EP023437HU	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Tissue factor pathway inhibitor(TFPI),partial expressed in E.coli
Rabbit Tissue factor pathway inhibitor (TFPI)
1-CSB-YP023437RB	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rabbit Tissue factor pathway inhibitor(TFPI) expressed in Yeast
Active Tissue Factor Pathway Inhibitor (TFPI)
APA394Hu61	Cloud-Clone	10ug	360 EUR
Rabbit Tissue factor pathway inhibitor (TFPI)
1-CSB-EP023437RB	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rabbit Tissue factor pathway inhibitor(TFPI) expressed in E.coli
Rabbit Tissue factor pathway inhibitor (TFPI)
1-CSB-BP023437RB	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rabbit Tissue factor pathway inhibitor(TFPI) expressed in Baculovirus
Rabbit Tissue factor pathway inhibitor (TFPI)
1-CSB-MP023437RB	Cusabio	Ask for price Ask for price Ask for price Ask for price	100ug 1MG 200ug 500ug
Description: Recombinant Rabbit Tissue factor pathway inhibitor(TFPI) expressed in Mammalian cell
Tissue Factor Pathway Inhibitor (TFPI) Protein
20-abx261170	Abbexa	Ask for price Ask for price Ask for price	1 mg 20 ug 5 ug
Tissue Factor Pathway Inhibitor (TFPI) Protein
abx261170-10g	Abbexa	10 µg	325 EUR
Tissue Factor Pathway Inhibitor (TFPI) Protein
abx261170-2g	Abbexa	2 µg	225 EUR
Horse TFPI (Tissue factor pathway inhibitor)
MBS766164-10x96StripWells	MyBiosource	10x96-Strip-Wells	3900 EUR
Horse TFPI (Tissue factor pathway inhibitor)
MBS766164-48StripWells	MyBiosource	48-Strip-Wells	340 EUR
Horse TFPI (Tissue factor pathway inhibitor)
MBS766164-5x96StripWells	MyBiosource	5x96-Strip-Wells	2045 EUR
Horse TFPI (Tissue factor pathway inhibitor)
MBS766164-96StripWells	MyBiosource	96-Strip-Wells	455 EUR
Eukaryotic Tissue Factor Pathway Inhibitor (TFPI)
EPA394Hu61	Cloud-Clone	10ug	200 EUR
Eukaryotic Tissue Factor Pathway Inhibitor (TFPI)
RPU58805-100ug	Biomatik Corporation	100ug	672 EUR
Eukaryotic Tissue Factor Pathway Inhibitor (TFPI)
RPU58805-1mg	Biomatik Corporation	1mg	3120 EUR
Eukaryotic Tissue Factor Pathway Inhibitor (TFPI)
RPU58805-50ug	Biomatik Corporation	50ug	495 EUR
Eukaryotic Tissue Factor Pathway Inhibitor (TFPI)
MBS2124279-001mg	MyBiosource	0.01mg	185 EUR
Eukaryotic Tissue Factor Pathway Inhibitor (TFPI)
MBS2124279-005mg	MyBiosource	0.05mg	340 EUR
Eukaryotic Tissue Factor Pathway Inhibitor (TFPI)
MBS2124279-01mg	MyBiosource	0.1mg	515 EUR
Eukaryotic Tissue Factor Pathway Inhibitor (TFPI)
MBS2124279-02mg	MyBiosource	0.2mg	630 EUR
Eukaryotic Tissue Factor Pathway Inhibitor (TFPI)
MBS2124279-05mg	MyBiosource	0.5mg	1205 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU50613-100ug	Biomatik Corporation	100ug	431.2 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU50613-1mg	Biomatik Corporation	1mg	1911 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU50613-50ug	Biomatik Corporation	50ug	346.5 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44028-100ug	Biomatik Corporation	100ug	517 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44028-1mg	Biomatik Corporation	1mg	2293.2 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44028-50ug	Biomatik Corporation	50ug	415.8 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44029-100ug	Biomatik Corporation	100ug	443.3 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44029-1mg	Biomatik Corporation	1mg	1747.2 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44029-50ug	Biomatik Corporation	50ug	268.8 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44030-100ug	Biomatik Corporation	100ug	566.5 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44030-1mg	Biomatik Corporation	1mg	2511.6 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44030-50ug	Biomatik Corporation	50ug	455.4 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44031-100ug	Biomatik Corporation	100ug	517 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44031-1mg	Biomatik Corporation	1mg	2293.2 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44031-50ug	Biomatik Corporation	50ug	415.8 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44032-100ug	Biomatik Corporation	100ug	517 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44032-1mg	Biomatik Corporation	1mg	2293.2 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPU44032-50ug	Biomatik Corporation	50ug	415.8 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPA394Hu01	Cloud-Clone	10ug	168 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPA394Hu02	Cloud-Clone	10ug	168 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Hu02	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPA394Hu03	Cloud-Clone	10ug	168 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Hu03	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPA394Mu01	Cloud-Clone	10ug	140 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Mu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPA394Ra01	Cloud-Clone	10ug	112 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Ra01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
RPA394Rb01	Cloud-Clone	10ug	184 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
4-RPA394Rb01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rabbit Tissue Factor Pathway Inhibitor expressed in: E.coli
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011794-001mg	MyBiosource	0.01mg	170 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011794-005mg	MyBiosource	0.05mg	295 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011794-01mg	MyBiosource	0.1mg	445 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011794-02mg	MyBiosource	0.2mg	540 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011794-05mg	MyBiosource	0.5mg	1025 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011249-001mg	MyBiosource	0.01mg	140 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011249-005mg	MyBiosource	0.05mg	225 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011249-01mg	MyBiosource	0.1mg	305 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011249-02mg	MyBiosource	0.2mg	375 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011249-05mg	MyBiosource	0.5mg	700 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011961-001mg	MyBiosource	0.01mg	175 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011961-005mg	MyBiosource	0.05mg	315 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011961-01mg	MyBiosource	0.1mg	480 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011961-02mg	MyBiosource	0.2mg	585 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2011961-05mg	MyBiosource	0.5mg	1110 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2030190-001mg	MyBiosource	0.01mg	155 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2030190-005mg	MyBiosource	0.05mg	260 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2030190-01mg	MyBiosource	0.1mg	375 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2030190-02mg	MyBiosource	0.2mg	460 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2030190-05mg	MyBiosource	0.5mg	860 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2009275-001mg	MyBiosource	0.01mg	170 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2009275-005mg	MyBiosource	0.05mg	295 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2009275-01mg	MyBiosource	0.1mg	445 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2009275-02mg	MyBiosource	0.2mg	540 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2009275-05mg	MyBiosource	0.5mg	1025 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2009965-001mg	MyBiosource	0.01mg	170 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2009965-005mg	MyBiosource	0.05mg	295 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2009965-01mg	MyBiosource	0.1mg	445 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2009965-02mg	MyBiosource	0.2mg	540 EUR
Recombinant Tissue Factor Pathway Inhibitor (TFPI)
MBS2009965-05mg	MyBiosource	0.5mg	1025 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody (FITC)
20-abx274012	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody (FITC)
20-abx274146	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody Pair
20-abx370061	Abbexa	Ask for price Ask for price	10 × 96 tests 5 × 96 tests
Tissue Factor Pathway Inhibitor (TFPI) Antibody Pair
20-abx370161	Abbexa	Ask for price Ask for price	10 × 96 tests 5 × 96 tests
Tissue Factor Pathway Inhibitor (TFPI) Antibody Pair
20-abx370357	Abbexa	Ask for price Ask for price	10 × 96 tests 5 × 96 tests
Tissue Factor Pathway Inhibitor (TFPI) Antibody Pair
20-abx370374	Abbexa	Ask for price Ask for price	10 × 96 tests 5 × 96 tests
Tissue Factor Pathway Inhibitor (TFPI) Antibody (FITC)
abx274012-25mg	Abbexa	25 mg	975 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody (FITC)
abx274012-5mg	Abbexa	5 mg	412.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody (FITC)
abx274146-05ml	Abbexa	0.5 ml	425 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody Pair
abx370061-100g	Abbexa	100 µg	1437.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody Pair
abx370161-100g	Abbexa	100 µg	1350 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody Pair
abx370357-100g	Abbexa	100 µg	887.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody Pair
abx370374-100g	Abbexa	100 µg	1437.5 EUR
Human Tissue Factor Pathway Inhibitor (TFPI) Antibody
11621-05011	AssayPro	150 ug	260.4 EUR
Rat Tissue Factor Pathway Inhibitor (TFPI) ELISA
KT-60930	Kamiya Biomedical Company	96 tests	998 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody (Biotin)
20-abx271976	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody (Biotin)
20-abx272693	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody (Biotin)
20-abx273169	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody (Biotin)
20-abx274501	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug
Tissue Factor Pathway Inhibitor (TFPI) Antibody (Biotin)
abx271976-1ml	Abbexa	1 ml	525 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody (Biotin)
abx271976-200l	Abbexa	200 µl	275 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody (Biotin)
abx272693-1ml	Abbexa	1 ml	762.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody (Biotin)
abx272693-200l	Abbexa	200 µl	337.5 EUR
Tissue Factor Pathway Inhibitor (TFPI) Antibody (Biotin)
abx273169-25mg	Abbexa	25 mg	800 EUR

Gli studi sono stati valutati utilizzando la tassonomia della forza della raccomandazione e tutti tranne sette hanno ricevuto il più alto livello di evidenza. Per valutare l’efficacia, è stato effettuato un confronto fianco a fianco utilizzando la riduzione del conteggio delle lesioni da acne alla settimana 12 per i gruppi di studio trattati con terapia di associazione fissa o monoterapia con retinoidi. Ventinove studi contenenti dati di efficacia rilevanti per la terapia di associazione fissa e la monoterapia con retinoidi sono riassunti qui. Nove studi hanno confrontato la terapia di associazione fissa con la monoterapia con retinoidi; in otto di questi studi, la terapia di combinazione fissa è stata significativamente più efficace nel ridurre il numero di lesioni da acne. Questa revisione basata sull’evidenza analizza le prove cliniche fino ad oggi per queste terapie per fornire una guida nella determinazione del trattamento appropriato per i pazienti con acne lieve-moderata.